{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T21:32:39Z","timestamp":1762032759156},"reference-count":10,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Defined candidate human vaccines for treating infection by\n            <jats:italic>Yersinia pestis<\/jats:italic>\n            , the agent of plague, have been developed. To facilitate evaluation of the vaccines' efficacy, the in vitro caspase-3 assay for cytotoxicity-neutralizing activity was modified and reevaluated. Immune serum-mediated caspase-3 neutralizing activity correlated with protection against infection in a nonhuman primate vaccine model of plague immunity.\n          <\/jats:p>","DOI":"10.1128\/cvi.00091-08","type":"journal-article","created":{"date-parts":[[2008,5,15]],"date-time":"2008-05-15T01:09:46Z","timestamp":1210813786000},"page":"1134-1137","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["Modified Caspase-3 Assay Indicates Correlation of Caspase-3 Activity with Immunity of Nonhuman Primates to\n            <i>Yersinia pestis<\/i>\n            Infection"],"prefix":"10.1128","volume":"15","author":[{"given":"Susan","family":"Welkos","sequence":"first","affiliation":[{"name":"Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Frederick, Maryland 21702"},{"name":"Biostatistical Services Division, USAMRIID, Frederick, Maryland 21702"},{"name":"Midwest Research Institute, Frederick, MD 21702"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Norris","sequence":"additional","affiliation":[{"name":"Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Frederick, Maryland 21702"},{"name":"Biostatistical Services Division, USAMRIID, Frederick, Maryland 21702"},{"name":"Midwest Research Institute, Frederick, MD 21702"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Adamovicz","sequence":"additional","affiliation":[{"name":"Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Frederick, Maryland 21702"},{"name":"Biostatistical Services Division, USAMRIID, Frederick, Maryland 21702"},{"name":"Midwest Research Institute, Frederick, MD 21702"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00398-06"},{"key":"e_1_3_2_3_2","unstructured":"Case studies for government. 2008"},{"key":"e_1_3_2_4_2","unstructured":"Guidance for industry: bioanalytical method validation. 2001"},{"key":"e_1_3_2_5_2","unstructured":"Development of animal models and assays for plague vaccines. 2005"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/S0264-410X(98)80110-2","volume":"16","year":"1998","unstructured":"Heath, D. 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