{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:41:05Z","timestamp":1789389665089,"version":"build-2803163510"},"reference-count":28,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Meningococcal group C polysaccharide-protein conjugate vaccines (MCV) prime infants and children for memory anticapsular responses upon subsequent exposure to unconjugated polysaccharide. The objective of this study was to determine whether MCV primes vaccine-nai\u0308ve adults and adults previously vaccinated with meningococcal polysaccharide vaccine (MPSV) for memory antibody responses. Meningococcal vaccine-nai\u0308ve adults were randomized to receive either MCV (MCV\/nai\u0308ve group) (\n            <jats:italic>n<\/jats:italic>\n            = 35) or pneumococcal conjugate vaccine (PCV) (PCV\/nai\u0308ve group) (\n            <jats:italic>n<\/jats:italic>\n            = 34). Participants with a history of receiving MPSV were given MCV (MCV\/MPSV group) (\n            <jats:italic>n<\/jats:italic>\n            = 26). All subjects were challenged 10 months later with one-fifth of the usual dose of MPSV (10 \u03bcg of each polysaccharide). Sera were obtained before the conjugate vaccination and before and 7 days after the MPSV challenge and assayed for immunoglobulin G (IgG) anticapsular antibody concentrations and bactericidal titers. The MCV\/nai\u0308ve group had 7- to 10-fold-higher serum IgG and bactericidal responses after the MPSV challenge than the PCV\/nai\u0308ve group (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001). The increases (\n            <jats:italic>n<\/jats:italic>\n            -fold) in anticapsular antibody concentrations in the MCV\/nai\u0308ve group were greatest in subjects with antibody concentrations of \u22642 \u03bcg\/ml before the challenge (geometric mean increase [\n            <jats:italic>n<\/jats:italic>\n            -fold] of 8.3 versus 1.1 in subjects with concentrations of &gt;2 \u03bcg\/ml before the challenge;\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.0001). Only 3 of 11 MCV-vaccinated subjects who had received MPSV before enrollment and who had antibody concentrations of \u22642 \u03bcg\/ml before the polysaccharide challenge showed more-than-twofold increases in anticapsular antibody concentration or bactericidal titer after the challenge. MCV vaccination of meningococcal vaccine-nai\u0308ve adults primes for robust memory antibody responses. There was no evidence of induction of memory by MCV in adults previously vaccinated with MPSV.\n          <\/jats:p>","DOI":"10.1128\/cvi.00123-06","type":"journal-article","created":{"date-parts":[[2006,6,7]],"date-time":"2006-06-07T17:07:13Z","timestamp":1149700033000},"page":"605-610","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Priming for Immunologic Memory in Adults by Meningococcal Group C Conjugate Vaccination"],"prefix":"10.1128","volume":"13","author":[{"given":"David M.","family":"Vu","sequence":"first","affiliation":[{"name":"Children's Hospital Oakland Research Institute, Oakland, California"},{"name":"Chiron Corporation, Emeryville, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberdina W.","family":"de Boer","sequence":"additional","affiliation":[{"name":"Children's Hospital Oakland Research Institute, Oakland, California"},{"name":"Chiron Corporation, Emeryville, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Danzig","sequence":"additional","affiliation":[{"name":"Children's Hospital Oakland Research Institute, Oakland, California"},{"name":"Chiron Corporation, Emeryville, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Santos","sequence":"additional","affiliation":[{"name":"Children's Hospital Oakland Research Institute, Oakland, California"},{"name":"Chiron Corporation, Emeryville, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget","family":"Canty","sequence":"additional","affiliation":[{"name":"Children's Hospital Oakland Research Institute, Oakland, California"},{"name":"Chiron Corporation, Emeryville, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty M.","family":"Flores","sequence":"additional","affiliation":[{"name":"Children's Hospital Oakland Research Institute, Oakland, California"},{"name":"Chiron Corporation, Emeryville, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan M.","family":"Granoff","sequence":"additional","affiliation":[{"name":"Children's Hospital Oakland Research Institute, Oakland, California"},{"name":"Chiron Corporation, Emeryville, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1002\/(SICI)1521-4141(200004)30:4<1214::AID-IMMU1214>3.0.CO;2-D","volume":"30","year":"2000","unstructured":"Baxendale, H. E., Z. Davis, H. N. White, M. B. Spellerberg, F. K. Stevenson, and D. Goldblatt. 2000. Immunogenetic analysis of the immune response to pneumococcal polysaccharide. Eur. J. Immunol.30:1214-1223.","journal-title":"Eur. J. Immunol."},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1017\/S0950268899003787","volume":"124","year":"2000","unstructured":"Borrow, R., A. J. Fox, P. C. Richmond, S. Clark, F. Sadler, J. Findlow, R. Morris, N. T. Begg, and K. A. Cartwright. 2000. Induction of immunological memory in UK infants by a meningococcal A\/C conjugate vaccine. Epidemiol. Infect.124:427-432.","journal-title":"Epidemiol. Infect."},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1086\/322024","volume":"184","year":"2001","unstructured":"Borrow, R., D. Goldblatt, N. Andrews, P. Richmond, J. Southern, and E. Miller. 2001. Influence of prior meningococcal C polysaccharide vaccination on the response and generation of memory after meningococcal C conjugate vaccination in young children. J. Infect. Dis.184:377-380.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1086\/344324","volume":"186","year":"2002","unstructured":"Borrow, R., D. Goldblatt, N. Andrews, J. Southern, L. Ashton, S. Deane, R. Morris, K. Cartwright, and E. Miller. 2002. Antibody persistence and immunological memory at age 4 years after meningococcal group C conjugate vaccination in children in the United Kingdom. J. Infect. Dis.186:1353-1357.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1574-695X.2000.tb01460.x","volume":"28","year":"2000","unstructured":"Borrow, R., P. Richmond, E. B. Kaczmarski, A. Iverson, S. L. Martin, J. Findlow, M. Acuna, E. Longworth, R. O'Connor, J. Paul, and E. 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