{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:36:35Z","timestamp":1792251395633,"version":"4.4.0"},"reference-count":48,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup>T cells are a population of regulatory T cells responsible for the modulation of the immune response in several autoimmune and infectious disease models. We previously showed that adoptive transfer of enriched CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup>T cells also plays a major role in the prevention of arthritis in<jats:italic>Borrelia<\/jats:italic>-vaccinated (<jats:italic>Borrelia burgdorferi<\/jats:italic>isolate 297) and -challenged (<jats:italic>B. bissettii<\/jats:italic>) mice. Here, we present evidence that administration of anti-CD25 antibody at the time of challenge or at later intervals fails to enhance the development of severe destructive osteoarthropathy in<jats:italic>Borrelia<\/jats:italic>-vaccinated C57BL mice. However,<jats:italic>Borrelia<\/jats:italic>-vaccinated and -challenged mice receiving anti-CD25 antibody developed decreased borreliacidal antibody titers compared to vaccinated and challenged controls. These findings suggest that additional mechanisms besides CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup>T cells are involved in the regulation of the immune response to<jats:italic>Borrelia<\/jats:italic>infection following vaccination.<\/jats:p>","DOI":"10.1128\/cvi.00137-06","type":"journal-article","created":{"date-parts":[[2006,8,7]],"date-time":"2006-08-07T16:53:13Z","timestamp":1154969593000},"page":"884-891","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Anti-CD25 Antibody Treatment of Mice Vaccinated and Challenged with<i>Borrelia<\/i>spp. Does Not Exacerbate Arthritis but Inhibits Borreliacidal Antibody Production"],"prefix":"10.1128","volume":"13","author":[{"given":"Dean T.","family":"Nardelli","sequence":"first","affiliation":[{"name":"Wisconsin State Laboratory of Hygiene and Departments of"},{"name":"Comparative Biomedical Sciences"},{"name":"Bacteriology"},{"name":"Medical Microbiology and Immunology, University of Wisconsin"},{"name":"Department of Pathology, Veterans Administration Hospital, Madison"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F.","family":"Warner","sequence":"additional","affiliation":[{"name":"Wisconsin State Laboratory of Hygiene and Departments of"},{"name":"Comparative Biomedical Sciences"},{"name":"Bacteriology"},{"name":"Medical Microbiology and Immunology, University of Wisconsin"},{"name":"Department of Pathology, Veterans Administration Hospital, Madison"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Callister","sequence":"additional","affiliation":[{"name":"Wisconsin State Laboratory of Hygiene and Departments of"},{"name":"Comparative Biomedical Sciences"},{"name":"Bacteriology"},{"name":"Medical Microbiology and Immunology, University of Wisconsin"},{"name":"Department of Pathology, Veterans Administration Hospital, Madison"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald F.","family":"Schell","sequence":"additional","affiliation":[{"name":"Wisconsin State Laboratory of Hygiene and Departments of"},{"name":"Comparative Biomedical Sciences"},{"name":"Bacteriology"},{"name":"Medical Microbiology and Immunology, University of Wisconsin"},{"name":"Department of Pathology, Veterans Administration Hospital, Madison"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"4850","volume":"164","year":"2002","unstructured":"Almeida, A. R., N Legrand, M. Papiernik, and A. A. Freitas. 2002. Homeostasis of peripheral CD4+ T cells: IL-2R\u03b1 and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J. Immunol.164:4850-4860.","journal-title":"J. Immunol."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.13.2.289-296.2006"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1084\/jem.184.2.387","volume":"184","year":"1996","unstructured":"Asano, M., M. Toda, N. Sakaguchi, and S. Sakaguchi. 1996. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med.184:387-396.","journal-title":"J. Exp. Med."},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0966-3274(02)00052-7","volume":"10","year":"2002","unstructured":"Baan, C. C., I. C. van Riemsdijk-Overbeeke, M. J. A. M. Boelaars-van Haperen, J. M. N. Ijzermans, and W. Weimar. 2002. Inhibition of the IL-15 pathway in anti-CD25 mAb treated renal allograft recipients. Transplant Immunol.10:81-87.","journal-title":"Transplant Immunol."},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.4049\/jimmunol.167.3.1245","volume":"167","year":"2001","unstructured":"Baecher-Allan, C., J. A. Brown, G. J. Freeman, and D. A. Hafler. 2001. CD4+CD25high regulatory cells in human peripheral blood. J. Immunol.167:1245-1253.","journal-title":"J. Immunol."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.6.3437-3442.2003"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.4049\/jimmunol.174.6.3290","volume":"174","year":"2005","unstructured":"Bushell, A., E. Jones, A. Gallimore, and K. Wood. 2005. The generation of CD4+CD25+ regulatory T cells that prevent allograft rejection does not compromise immunity to a viral pathogen. J. Immunol.174:3290-3297.","journal-title":"J. Immunol."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/cdli.3.4.399-402.1996"},{"key":"e_1_3_2_10_2","first-page":"44","volume":"10","year":"2003","unstructured":"Christopherson, J. A., E. L. Munson, D. M. England, C. L. Croke, M. C. Remington, M. L. Molitor, D. J. DeCoster, S. M. Callister, and R. F. Schell. 2003. Destructive arthritis in vaccinated interferon gamma-deficient mice challenged with Borrelia burgdorferi: modulation by tumor necrosis factor alpha. Clin. Diagn. Lab. Immunol.10:44-52.","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.4049\/jimmunol.145.6.1719","volume":"145","year":"1990","unstructured":"Cox, G. W., B. J. Mathieson, S. L. Giardina, and L. Varesio. 1990. Characterization of IL-2 receptor expression and function on murine macrophages. J. Immunol.145:1719-1726.","journal-title":"J. Immunol."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.2.658-663.2000"},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1002\/eji.200535500","volume":"36","year":"2006","unstructured":"Eddahri, F., G. Oldenhove, S. Denanglaire, J. Urbain, O. Leo, and F. Andris. 2006. CD4+CD25+ regulatory T cells control the magnitude of T-dependent humoral immune responses to exogenous antigens. Eur. J. Immunol.36:855-863.","journal-title":"Eur. J. Immunol."},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1098\/rstb.2005.1695","volume":"360","year":"2005","unstructured":"Fehervari, Z., and S. Sakaguchi. 2005. CD4+ regulatory cells as a potential immunotherapy. Philos. Trans. R. Soc. Lond. B360:1647-1661.","journal-title":"Philos. Trans. R. Soc. Lond. B"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.jaci.2005.08.051","volume":"116","year":"2005","unstructured":"Goleva, E., I. D. Cardona, L. Ou, and D. Y. M. Leung. 2005. Factors that regulate naturally occurring T regulatory cell-mediated suppression. J. Allergy Clin. Immunol.116:1094-1100.","journal-title":"J. Allergy Clin. Immunol."},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"185","DOI":"10.4049\/jimmunol.138.1.185","volume":"138","year":"1987","unstructured":"Hancock, W. W., W. A. Muller, and R. S. Cotran. 1987. Interleukin 2 receptors are expressed by alveolar macrophages during pulmonary sarcoidosis and are inducible by lymphokine treatment of normal human lung macrophages, blood monocytes, and monocyte cell lines. J. Immunol.138:185-191.","journal-title":"J. Immunol."},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.4049\/jimmunol.162.9.5317","volume":"162","year":"1999","unstructured":"Itoh, M., T. Takahashi, N. Sakaguchi, Y. Kuniyasu, J. Shimizu, F. Otsuka, and S. Sakaguchi. 1999. Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol.162:5317-5326.","journal-title":"J. Immunol."},{"key":"e_1_3_2_18_2","first-page":"1","volume":"2","year":"2002","unstructured":"Jones, E., M. Dahm-Vicker, A. K. Simon, A. Green, F. Powrie, V. Cerundolo, and A. Gallimore. 2002. Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice. Cancer Immunol.2:1-10.","journal-title":"Cancer Immunol."},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","first-page":"S118","DOI":"10.1086\/515064","volume":"28","year":"1999","unstructured":"Keitel, W. A. 1999. Cellular and acellular pertussis vaccines in adults. Clin. Infect. Dis.28(Suppl. 2):S118-S123.","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_2_20_2","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.4049\/jimmunol.176.6.3301","volume":"176","year":"2006","unstructured":"Kohm, A. P., J. S. McMahon, J. R. Podojil, W. Smith Begolka, M. DeGutes, D. J. Kasprowicz, S. F. Ziegler, and S. D. Miller. 2006. Cutting edge: anti-CD25 monoclonal antibody injection results in functional inactivation, not depletion, of CD4+CD25+ T regulatory cells. J. Immunol.176:3301-3305.","journal-title":"J. Immunol."},{"key":"e_1_3_2_21_2","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1093\/intimm\/12.8.1145","volume":"12","year":"2000","unstructured":"Kuniyasu, Y., T. Takahashi, M. Itoh, J. Schmizu, G. Toda, and S. Sakaguchi. 2000. Naturally anergic and suppressive CD25+CD4+ T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation. Int. Immunol.12:1145-1155.","journal-title":"Int. Immunol."},{"key":"e_1_3_2_22_2","first-page":"2.1","year":"2001","unstructured":"Lewis, D. E., and G. R. Harriman. 2001. Cells and tissues of the immune system, p. 2.1-2.21. In R. R. Rich, T. A. Fleiser, W. T. Shearer, B. L. Kotzin, and H. W. Schroeder, Jr. (ed.), Clinical immunology principles and practice. Mosby, London, England.","journal-title":"Clinical immunology principles and practice."},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.7.2825-2833.1994"},{"key":"e_1_3_2_24_2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/rheumatology\/keh477","volume":"44","year":"2005","unstructured":"Loughry, A., S. Fairchild, N. Athanasou, J. Edwards, and F. C. Hall. 2005. Inflammatory arthritis and dermatitis in thymectomized, CD25+ cell-depleted mice. Rheumatology44:299-308.","journal-title":"Rheumatology"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.10.4367-4374.1993"},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nri1435","volume":"4","year":"2004","unstructured":"Malek, T. R., and A. L. Bayer. 2004. Tolerance, not immunity, crucially depends on IL-2. Nat. Rev. Immunol.4:665-674.","journal-title":"Nat. Rev. Immunol."},{"key":"e_1_3_2_27_2","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/ni0901-816","volume":"2","year":"2001","unstructured":"Maloy, K. J., and F. Powrie. 2001. Regulatory T cells in the control of immune pathology. Nat. Immunol.2:816-822.","journal-title":"Nat. Immunol."},{"key":"e_1_3_2_28_2","doi-asserted-by":"crossref","first-page":"5979","DOI":"10.4049\/jimmunol.168.12.5979","volume":"168","year":"2002","unstructured":"McHugh, R. S., and E. M. Shevach. 2002. Cutting edge: depletion of CD4+CD25+ regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune disease. J. Immunol.168:5979-5983.","journal-title":"J. Immunol."},{"key":"e_1_3_2_29_2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1146\/annurev.iy.11.040193.001333","volume":"11","year":"1993","unstructured":"Minami, Y., T. Kono, T. Miyazaki, and T. Taniguchi. 1993. The IL-2 receptor complex: its structure, function, and target gene. Annu. Rev. Immunol.11:245-267.","journal-title":"Annu. Rev. Immunol."},{"key":"e_1_3_2_30_2","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1084\/jem.20050648","volume":"203","year":"2006","unstructured":"Miyara, M., Z. Amoura, C. Parizot, C. Badoual, K. Dorgham, S. Trad, M. Kambouchner, D. Valeyre, C. Chapelon-Abric, P. Debr\u00e9, J.-C. Piette, and G. Gorochov. 2006. The immune paradox of sarcoidosis and regulatory T cells. J. Exp. Med.203:359-370.","journal-title":"J. Exp. Med."},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.11.7264"},{"key":"e_1_3_2_32_2","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1002\/art.11063","volume":"48","year":"2003","unstructured":"Morgan, M. E., R. P. M. Sutmuller, H. J. Witteveen, L. M. van Duivenvoorde, E. Zanelli, C. J. M. Melief, A. Snijders, R. Offringa, R. R. P. de Vries, and R. E. M. Toes. 2003. CD25+ T cell depletion hastens the onset of severe disease in collagen-induced arthritis. Arthritis Rheum.48:1452-1460.","journal-title":"Arthritis Rheum."},{"key":"e_1_3_2_33_2","first-page":"3551","volume":"89","year":"1991","unstructured":"Nakanishi, K., S. Hirose, T. Yoshimoto, H. Ishizashi, K. Hiroishi, T. Tanaka, T. Kono, M. Miyasaka, T. Taniguchi, and K. Higashino. 1991. Role and regulation of the interleukin (IL)-2 receptor \u03b1 and \u03b2 chains in IL-2-driven B-cell growth. Proc. Natl. Acad. Sci. USA89:3551-3555.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_2_34_2","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1128\/CDLI.12.6.786-792.2005","volume":"12","year":"2005","unstructured":"Nardelli, D. T., J. P. Cloute, K. H. K. Luk, J. Torrealba, T. F. Warner, S. M. Callister, and R. F. Schell. 2005. CD4+ CD25+ T cells prevent arthritis associated with Borrelia vaccination and infection. Clin. Diagn. Lab. Immunol.12:786-792.","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"e_1_3_2_35_2","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1128\/CDLI.11.6.1075-1084.2004","volume":"11","year":"2004","unstructured":"Nardelli, D. T., M. A. Burchill, D. M. England, J. Torrealba, S. M. Callister, and R. F. Schell. 2004. Association of CD4+ CD25+ T cells with prevention of severe destructive arthritis in Borrelia burgdorferi-vaccinated and challenged interferon gamma-deficient mice treated with anti-interleukin-17 antibody. Clin. Diagn. Lab. Immunol.11:1075-1084.","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"e_1_3_2_36_2","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.4049\/jimmunol.172.7.3983","volume":"172","year":"2004","unstructured":"Nelson, B. H. 2004. IL-2, regulatory T cells, and tolerance. J. Immunol.172:3983-3988.","journal-title":"J. Immunol."},{"key":"e_1_3_2_37_2","first-page":"3128","volume":"59","year":"1999","unstructured":"Onizuka, S., I. Tawara, J. Shimizu, S. Sakaguchi, T. Fujita, and E. Nakayama. 1999. Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor \u03b1) monoclonal antibody. Cancer Res.59:3128-3133.","journal-title":"Cancer Res."},{"key":"e_1_3_2_38_2","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.4049\/jimmunol.155.3.1151","volume":"155","year":"1995","unstructured":"Sakaguchi, S., N. Sakaguchi, M. Asano, M. Itoh, and M. Toda. 1995. Immunologic self-tolerance by activated T cells expressing IL-2 receptor \u03b1-chain (CD25). J. Immunol.155:1151-1164.","journal-title":"J. Immunol."},{"key":"e_1_3_2_39_2","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S1074-7613(00)80195-8","volume":"12","year":"2000","unstructured":"Salomon, B., D. J. Lenschow, L. Rhee, N. Ashourian, B. Singh, A. Sharpe, and J. A. Bluestone. 2000. B7\/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity12:431-440.","journal-title":"Immunity"},{"key":"e_1_3_2_40_2","first-page":"2336","volume":"56","year":"1998","unstructured":"Schmitz, J. L., R. F. Schell, A. Hejka, D. M. England, and L. Konick. 1998. Induction of Lyme arthritis in LSH hamsters. Infect. Immun.56:2336-2342.","journal-title":"Infect. Immun."},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.59.6.1916-1921.1991"},{"key":"e_1_3_2_42_2","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1002\/art.20500","volume":"50","year":"2004","unstructured":"Shevach, E. M. 2004. Regulatory\/suppressor T cells in health and disease. Arthritis Rheum.50:2721-2724.","journal-title":"Arthritis Rheum."},{"key":"e_1_3_2_43_2","first-page":"99","year":"1960","unstructured":"Steel, R. G. D., and J. H. Torrie. 1960. Principles and procedures of statistics with special reference to the biological sciences, p. 99-276. McGraw-Hill Book Co., New York, N.Y.","journal-title":"Principles and procedures of statistics with special reference to the biological sciences"},{"key":"e_1_3_2_44_2","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.4049\/jimmunol.160.3.1212","volume":"160","year":"1998","unstructured":"Suri-Payer, E., A. Z. Amar, A. M. Thornton, and E. M. Shevach. 1998. CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J. Immunol.160:1212-1218.","journal-title":"J. Immunol."},{"key":"e_1_3_2_45_2","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1084\/jem.192.2.303","volume":"192","year":"2000","unstructured":"Takahashi, T., T. Tagami, S. Yamazaki, T. Uede, J. Shimizu, N. Sakaguchi, T. W. Mak, and S. Sakaguchi. 2000. Immunologic self-tolerance maintained by CD25+CD4+ regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med.192:303-309.","journal-title":"J. Exp. Med."},{"key":"e_1_3_2_46_2","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1093\/intimm\/10.12.1969","volume":"10","year":"1998","unstructured":"Takahashi, T., Y. Kuniyasu, M. Toda, N. Sakaguchi, M. Itoh, M. Iwata, J. Shimizu, and S. Sakaguchi. 1998. Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic\/suppressive state. Int. Immunol.10:1969-1980.","journal-title":"Int. Immunol."},{"key":"e_1_3_2_47_2","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.4049\/jimmunol.176.2.1266","volume":"176","year":"2006","unstructured":"Trenado, A., M. Sudres, Q. Tang, S. Maury, F. Charlotte, S. Gregoire, M. Bonyhadi, D. Klatzman, B. L. Salomon, and J. L. Cohen. 2006. Ex vivo-expanded CD4+CD25+ immunoregulatory T cells prevent graft-versus-host disease by inhibiting activation\/differentiation of pathogenic T cells. J. Immunol.176:1266-1273.","journal-title":"J. Immunol."},{"key":"e_1_3_2_48_2","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1126\/science.1117893","volume":"310","year":"2005","unstructured":"Wang, X., M. Rickert, and K. C. Garcia. 2005. Structure of the quaternary complex of interleukin-2 with its \u03b1, \u03b2 and \u03b3C receptors. Science310:1159-1163.","journal-title":"Science"},{"key":"e_1_3_2_49_2","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1073\/pnas.0408679102","volume":"102","year":"2005","unstructured":"Zelenay, S., T. Lopes-Carvalho, I. Caramalho, M. F. Moraes-Fontes, M. Rebelo, and J. Demengeot. 2005. Foxp3+ CD25\u2212 CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion. Proc. Natl. Acad. Sci. USA102:4091-4096.","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Clinical and Vaccine Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00137-06","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00137-06","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T12:20:29Z","timestamp":1683548429000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/CVI.00137-06"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":48,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1128\/CVI.00137-06"],"URL":"https:\/\/doi.org\/10.1128\/cvi.00137-06","relation":{},"ISSN":["1556-6811","1556-679X"],"issn-type":[{"value":"1556-6811","type":"print"},{"value":"1556-679X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8]]},"assertion":[{"value":"2006-04-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-05-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}