{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T07:03:56Z","timestamp":1791097436146,"version":"4.1.0"},"reference-count":54,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Recombinant clones of the carboxyl terminus of the major surface glycoprotein (MsgC) of<jats:italic>Pneumocystis jirovecii<\/jats:italic>are useful for analyzing serologic responses in humans. However, there is no standardized set of antigens in general use, which could lead to conflicting results. We have previously shown that human immunodeficiency virus type 1 (HIV-1)-infected patients with prior<jats:italic>Pneumocystis<\/jats:italic>pneumonia (PcP<jats:sup>+<\/jats:sup>) responded more frequently and more strongly to a clone of MsgC than did HIV-1-infected patients without PcP (PcP<jats:sup>\u2212<\/jats:sup>). Here we test three new clones of MsgC to determine the effect of antigenic sequence variation on immune reactivity in blood donors and HIV-infected patients previously analyzed for reactivity to our original MsgC clone. In Western blot analyses, PcP<jats:sup>+<\/jats:sup>patients exhibited the highest frequency of reactivity to each MsgC clone, and the frequency of reactivity with all four MsgC clones together was significantly higher in sera from PcP<jats:sup>+<\/jats:sup>patients than in sera from the other patient groups. Furthermore, in an enzyme-linked immunosorbent assay we found that the PcP<jats:sup>+<\/jats:sup>population had the highest level of reactivity to two of the four clones tested. One of the new clones could distinguish between PcP<jats:sup>+<\/jats:sup>and PcP<jats:sup>\u2212<\/jats:sup>populations, and two MsgC clones could distinguish blood donors from the other patient populations. The results show that inherent differences in MsgC amino acid sequence can affect recognition by antibodies independently of variations in protein length or patient population, and the utility of a clone depends on its sequence and on the populations tested.<\/jats:p>","DOI":"10.1128\/cvi.00140-06","type":"journal-article","created":{"date-parts":[[2006,10,6]],"date-time":"2006-10-06T20:24:23Z","timestamp":1160166263000},"page":"1071-1078","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Human Immunodeficiency Virus-Infected Patients with Prior<i>Pneumocystis<\/i>Pneumonia Exhibit Increased Serologic Reactivity to Several Major Surface Glycoprotein Clones"],"prefix":"10.1128","volume":"13","author":[{"given":"K. R.","family":"Daly","sequence":"first","affiliation":[{"name":"Veterans Affairs Medical Center"},{"name":"Division of Infectious Diseases, Department of Internal Medicine"},{"name":"Division of Epidemiology, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. V.","family":"Koch","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center"},{"name":"Division of Infectious Diseases, Department of Internal Medicine"},{"name":"Division of Epidemiology, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. J.","family":"Shire","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center"},{"name":"Division of Infectious Diseases, Department of Internal Medicine"},{"name":"Division of Epidemiology, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Levin","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center"},{"name":"Division of Infectious Diseases, Department of Internal Medicine"},{"name":"Division of Epidemiology, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. D.","family":"Walzer","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center"},{"name":"Division of Infectious Diseases, Department of Internal Medicine"},{"name":"Division of Epidemiology, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.5.1.74-77.1998"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1086\/375354","volume":"187","year":"2003","unstructured":"Bishop, L. R., and J. A. Kovacs. 2003. Quantitation of anti-Pneumocystis jiroveci antibodies in healthy persons and immunocompromised patients. J. Infect. Dis.187:1844-1848.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"A29","DOI":"10.1016\/S0167-5699(05)80009-X","volume":"12","year":"1991","unstructured":"Borst, P. 1991. Molecular genetics of antigenic variation. Immunol. Today12:A29-A33.","journal-title":"Immunol. Today"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/j.1699-0463.1993.tb00169.x","volume":"101","year":"1993","unstructured":"Buhl, L., O. P. Settnes, and P. L. Andersen. 1993. Antibodies to Pneumocystis carinii in Danish blood donors and AIDS patients with and without Pneumocystis carinii pneumonia. APMIS101:707-710.","journal-title":"APMIS"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0163-4453(90)92280-X","volume":"20","year":"1990","unstructured":"Burns, S. M., J. A. Read, P. L. Yap, and R. P. Brettle. 1990. Reduced concentrations of IgG antibodies to Pneumocystis carinii in HIV-infected patients during active Pneumocystis carinii infection and the possibility of passive immunization. J. Infect.20:33-39.","journal-title":"J. Infect."},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1099\/00222615-48-7-681","volume":"48","year":"1999","unstructured":"Chatterton, J. M., A. W. Joss, T. H. Pennington, and D. O. Ho-Yen. 1999. Usefulness of rat-derived antigen in the serodiagnosis of Pneumocystis carinii infection. J. Med. Microbiol.48:681-687.","journal-title":"J. Med. Microbiol."},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1086\/341565","volume":"186","year":"2002","unstructured":"Daly, K. R., C. J. Fichtenbaum, R. Tanaka, M. J. Linke, R. O'Bert, T. D. Thullen, M. S. Hui, A. G. Smulian, and P. D. Walzer. 2002. Serologic responses to epitopes of the major surface glycoprotein of Pneumocystis jiroveci differ in human immunodeficiency virus-infected and uninfected persons. J. Infect. Dis.186:644-651.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"848","DOI":"10.3201\/eid1005.030497","volume":"10","year":"2004","unstructured":"Daly, K. R., J. Koch, L. Levin, and Peter D. Walzer. 2004. Enzyme-linked immunosorbent assay and serologic responses to Pneumocystis jiroveci. Emerg. Infect. Dis.10:848-854.","journal-title":"Emerg. Infect. Dis."},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1086\/315734","volume":"182","year":"2000","unstructured":"Dworkin, M. S., D. L. Hanson, J. E. Kaplan, J. L. Jones, and J. W. Ward. 2000. Risk for preventable opportunistic infections in persons with AIDS after antiretroviral therapy increases CD4+ T lymphocyte counts above prophylaxis thresholds. J. Infect. Dis.182:611-615.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3109\/00365549409008588","volume":"26","year":"1994","unstructured":"Elvin, K., A. Bjorkman, N. Heurlin, B. M. Eriksson, L. Barkholt, and E. Linder. 1994. Seroreactivity to Pneumocystis carinii in patients with AIDS versus other immunosuppressed patients. Scand. J. Infect. Dis.26:33-40.","journal-title":"Scand. J. Infect. Dis."},{"key":"e_1_3_2_12_2","first-page":"89S","volume":"46","year":"1999","unstructured":"Frenkel, J. K. 1999. Pneumocystis pneumonia, an immunodeficiency-dependent disease (IDD): a critical historical overview. J. Eukaryot. Microbiol.46:89S-92S.","journal-title":"J. Eukaryot. Microbiol."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.8.3092-3101.1994"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.12.5052-5056.1997"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/infdis\/165.2.329","volume":"165","year":"1992","unstructured":"Gigliotti, F. 1992. Host species-specific antigenic variation of a mannosylated surface glycoprotein of Pneumocystis carinii. J. Infect. Dis.165:329-336.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1086\/515607","volume":"178","year":"1998","unstructured":"Gigliotti, F., B. A. Garvey, C. G. Haidaris, and A. G. Harmsen. 1998. Recognition of Pneumocystis carinii antigens by local antibody-secreting cells following resolution of P. carinii pneumonia in mice. J. Infect. Dis.178:235-242.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.6.1892-1899.1996"},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1086\/514128","volume":"176","year":"1997","unstructured":"Gigliotti, F., and A. G. Harmsen. 1997. Pneumocystis carinii host origin defines the antibody specificity and protective response induced by immunization. J. Infect. Dis.176:1322-1326.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_19_2","first-page":"1666","volume":"81","year":"1998","unstructured":"Gigliotti, F., and W. T. Hughes. 1998. Passive immunoprophylaxis with specific monoclonal antibody confers partial protection against Pneumocystis carinii pneumonitis in animal models. J. Clin. Investig.81:1666-1668.","journal-title":"J. Clin. Investig."},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.7.2391-2395.1995"},{"key":"e_1_3_2_21_2","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3109\/00365548809032473","volume":"20","year":"1988","unstructured":"Hofmann, B., P. B. Nielsen, N. Odum, J. Gerstoft, P. Platz, L. P. Ryder, A. G. Poulsen, L. Mathiesen, E. Dickmeiss, B. Norrild, H. K. Andersen, B. F. Westergaard, C. M. Nielsen, W. Holten-Andersen, M. Mojon, J. O. Nielsen, and A. Svejgaard. 1988. Humoral and cellular responses to Pneumocystis carinii, CMV, and herpes simplex in patients with AIDS and in controls. Scand. J. Infect. Dis.20:389-394.","journal-title":"Scand. J. Infect. Dis."},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1093\/infdis\/152.4.838","volume":"152","year":"1985","unstructured":"Hofmann, B., N. Odum, P. Platz, L. P. Ryder, A. Svejgaard, P. B. Nielsen, W. Holten-Andersen, J. O. Gerstoft, J. Nielsen, and M. Mojon. 1985. Humoral responses to Pneumocystis carinii in patients with acquired immunodeficiency syndrome and in immunocompromised homosexual men. J. Infect. Dis.152:838-840.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_23_2","doi-asserted-by":"crossref","first-page":"6034","DOI":"10.1016\/S0021-9258(18)53422-0","volume":"268","year":"1993","unstructured":"Kovacs, J. A., F. Powell, J. C. Edman, B. Lundgren, A. Martinez, B. Drew, and C. W. Angus. 1993. Multiple genes encode the major surface glycoprotein of Pneumocystis carinii. J. Biol. Chem.268:6034-6040.","journal-title":"J. Biol. Chem."},{"key":"e_1_3_2_24_2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1046\/j.1365-2958.2001.02620.x","volume":"42","year":"2001","unstructured":"Kutty, G., L. Ma, and J. A. Kovacs. 2001. Characterization of the expression site of the major surface glycoprotein of human-derived Pneumocystis carinii. Mol. Microbiol.42:183-193.","journal-title":"Mol. Microbiol."},{"key":"e_1_3_2_25_2","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/00365549850161511","volume":"30","year":"1998","unstructured":"Laursen, A. L., and P. L. Andersen. 1998. Low levels of IgG antibodies against Pneumocystis carinii among HIV-infected patients. Scand. J. Infect. Dis.30:495-499.","journal-title":"Scand. J. Infect. Dis."},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3347\/kjp.1998.36.2.127","volume":"36","year":"1998","unstructured":"Lee, M., S. R. Cho, Y. K. Park, M. H. Choi, and S. T. Hong. 1998. The effect of heterogeneous hyperimmune IgG antibody on prophylaxis and treatment of Pneumocystis carinii infection in rats. Korean J. Parasitol.36:127-132.","journal-title":"Korean J. Parasitol."},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.5.1.50-57.1998"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.15.6.1029-1035.1982"},{"key":"e_1_3_2_29_2","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1093\/infdis\/173.4.1034","volume":"173","year":"1996","unstructured":"Marcotte, H., D. Levesque, K. Delanay, A. Bourgeault, R. de la Durantaye, S. Brochu, and M. C. Lavoie. 1996. Pneumocystis carinii infection in transgenic B cell-deficient mice. J. Infect. Dis.173:1034-1037.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.9.4268-4273.1998"},{"key":"e_1_3_2_31_2","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/j.1699-0463.1988.tb00924.x","volume":"96","year":"1988","unstructured":"Nielsen, P. B., and M. Mojon. 1988. Enzyme-linked immunosorbent assay compared with indirect immunofluorescence test for detection of Pneumocystis carinii specific immunoglobulins G, M, and A. APMIS96:649-654.","journal-title":"APMIS"},{"key":"e_1_3_2_32_2","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1086\/313534","volume":"29","year":"1999","unstructured":"Nuesch, R., C. Bellini, and W. Zimmerli. 1999. Pneumocystis carinii pneumonia in human immunodeficiency virus (HIV)-positive and HIV-negative immunocompromised patients. Clin. Infect. Dis.29:1519-1523.","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_2_33_2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3347\/kjp.1999.37.2.109","volume":"37","year":"1999","unstructured":"Park, H. Y., S. U. Lee, S. W. Chae, S. Huh, J. R. Yu, J. Kim, and S. T. Hong. 1999. Variation of antigenicity and serological reaction to Pneumocystis carinii in Korea. Korean J. Parasitol.37:109-115.","journal-title":"Korean J. Parasitol."},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.2.805-809.1999"},{"key":"e_1_3_2_35_2","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1093\/infdis\/161.2.296","volume":"161","year":"1990","unstructured":"Peglow, S. L., A. G. Smulian, M. J. Linke, C. L. Pogue, S. Nurre, J. Crisler, J. Phair, J. W. Gold, D. Armstrong, and P. D. Walzer. 1990. Serologic responses to specific Pneumocystis carinii antigens in health and disease. J. Infect. Dis.161:296-306.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_36_2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1542\/peds.61.1.35","volume":"61","year":"1978","unstructured":"Pifer, L. L., W. T. Hughes, S. Stagno, and D. Woods. 1978. Pneumocystis carinii infection: evidence for high prevalence in normal and immunosuppressed children. Pediatrics61:35-41.","journal-title":"Pediatrics"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.25.6.991-995.1987"},{"key":"e_1_3_2_38_2","first-page":"36","volume":"142","year":"1988","unstructured":"Pifer, L. L., D. R. Woods, C. C. Edwards, R. E. Joyner, F. J. Anderson, and K. Arheart. 1988. Pneumocystis carinii serologic study in pediatric acquired immunodeficiency syndrome. Am. J. Dis. Child.142:36-39.","journal-title":"Am. J. Dis. Child."},{"key":"e_1_3_2_39_2","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1086\/314837","volume":"180","year":"1999","unstructured":"Pontesilli, O., S. Kerkhof-Garde, D. W. Notermans, N. A. Foudraine, M. T. Roos, M. R. Klein, S. A. Danner, J. M. Lange, and F. Miedema. 1999. Functional T-cell reconstitution and human immunodeficiency virus-1-specific cell-mediated immunity during highly active antiretroviral therapy. J. Infect. Dis.180:76-86.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_40_2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1550-7408.2005.00072.x","volume":"53","year":"2006","unstructured":"Redhead, S. A., M. T. Cushion, J. K. Frenkel, and J. R. Stringer. 2006. Pneumocystis and Trypanosoma cruzi: nomenclature and typifications. J. Eukaryot. Microbiol.53:2-11.","journal-title":"J. Eukaryot. Microbiol."},{"key":"e_1_3_2_41_2","first-page":"1243","volume":"67","year":"1993","unstructured":"Smulian, A. G., D. W. Sullivan, M. J. Linke, N. A. Halsey, T. C. Quinn, A. P. MacPhail, M. A. Hernandez-Avila, S. T. Hong, and P. D. Walzer. 1993. Geographic variation in the humoral response to Pneumocystis carinii. J. Infect. Dis.67:1243-1247.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_42_2","first-page":"141","year":"1994","unstructured":"Smulian, A. G., and P. D. Walzer. 1994. Serological studies of Pneumocystis carinii infection, p. 141-151. In P. D. Walzer (ed.), Pneumocystis carinii pneumonia. Marcel Dekker, New York, N.Y.","journal-title":"Pneumocystis carinii pneumonia"},{"key":"e_1_3_2_43_2","doi-asserted-by":"crossref","first-page":"891","DOI":"10.3201\/eid0809.020096","volume":"8","year":"2002","unstructured":"Stringer, J. R., C. B. Beard, R. F. Miller, and A. E. Wakefield. 2002. A new name (Pneumocystis jiroveci) for Pneumocystis from humans. Emerg. Infect. Dis.8:891-896.","journal-title":"Emerg. Infect. Dis."},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.2.627-639.2001"},{"key":"e_1_3_2_45_2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1046\/j.1365-2958.1996.375905.x","volume":"19","year":"1996","unstructured":"Sunkin, S. M., and J. R. Stringer. 1996. Translocation of surface antigen genes to a unique telomeric expression site in Pneumocystis carinii. Mol. Microbiol.19:283-295.","journal-title":"Mol. Microbiol."},{"key":"e_1_3_2_46_2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1046\/j.1365-2958.1997.4461806.x","volume":"25","year":"1997","unstructured":"Sunkin, S. M., and J. R. Stringer. 1997. Residence at the expression site is necessary and sufficient for the transcription of surface antigen genes of Pneumocystis carinii. Mol. Microbiol.25:147-160.","journal-title":"Mol. Microbiol."},{"key":"e_1_3_2_47_2","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1172\/JCI117960","volume":"95","year":"1995","unstructured":"Theus, S. A., R. P. Andrews, P. Steele, and P. D. Walzer. 1995. Adoptive transfer of lymphocytes sensitized to the major surface glycoprotein of Pneumocystis carinii confers protection in the rat. J. Clin. Investig.95:2587-2593.","journal-title":"J. Clin. Investig."},{"key":"e_1_3_2_48_2","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1086\/517363","volume":"177","year":"1998","unstructured":"Theus, S. A., N. Sawhney, A. G. Smulian, and P. D. Walzer. 1998. Proliferative and cytokine responses of human T lymphocytes isolated from human immunodeficiency virus-infected patients to the major surface glycoprotein of Pneumocystis carinii. J. Infect. Dis.177:238-241.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_49_2","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/S0264-410X(98)80113-8","volume":"16","year":"1998","unstructured":"Theus, S. A., A. G. Smulian, P. Steele, M. J. Linke, and P. D. Walzer. 1998. Immunization with the major surface glycoprotein of Pneumocystis carinii elicits a protective response. Vaccine16:1149-1157.","journal-title":"Vaccine"},{"key":"e_1_3_2_50_2","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/0168-9525(92)90330-7","volume":"8","year":"1992","unstructured":"Van der Ploeg, L. H. T., K. Gottesdiener, and M. G. S. Lee. 1992. Antigenic variation in African trypanosomes. Trends Genet.8:452-457.","journal-title":"Trends Genet."},{"key":"e_1_3_2_51_2","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1086\/319340","volume":"32","year":"2001","unstructured":"Vargas, S. L., W. T. Hughes, M. E. Santolaya, A. V. Ulloa, C. A. Ponce, C. E. Cabrera, F. Cumsille, and F. Gigliotti. 2001. Search for primary infection by Pneumocystis carinii in a cohort of normal, healthy infants. Clin. Infect. Dis.32:855-861.","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_2_52_2","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/bmb\/61.1.175","volume":"61","year":"2002","unstructured":"Wakefield, A. E. 2002. Pneumocystis carinii. Br. Med. Bull.61:175-188.","journal-title":"Br. Med. Bull."},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.6.2.149-155.1999"},{"key":"e_1_3_2_54_2","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0092-8674(00)80206-8","volume":"89","year":"1997","unstructured":"Zhang, J. R., J. M. Hardham, A. G. Barbour, and S. J. Norris. 1997. Antigenic variation in Lyme disease borreliae by promiscuous recombination of VMP-like sequence cassettes. Cell89:275-285.","journal-title":"Cell"},{"key":"e_1_3_2_55_2","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1172\/JCI13826","volume":"108","year":"2001","unstructured":"Zheng, M., J. E. Shellito, L. Marrero, Q. Zhong, S. Julian, P. Ye, V. Wallace, P. Schwarzenberger, and J. K. Kolls. 2001. CD4+ T cell-independent vaccination against Pneumocystis carinii in mice. J. Clin. Investig.108:1469-1474.","journal-title":"J. Clin. Investig."}],"container-title":["Clinical and Vaccine Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00140-06","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00140-06","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T05:17:37Z","timestamp":1707283057000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/CVI.00140-06"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":54,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["10.1128\/CVI.00140-06"],"URL":"https:\/\/doi.org\/10.1128\/cvi.00140-06","relation":{},"ISSN":["1556-6811","1556-679X"],"issn-type":[{"value":"1556-6811","type":"print"},{"value":"1556-679X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10]]},"assertion":[{"value":"2006-04-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-07-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}