{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T15:50:03Z","timestamp":1772639403396,"version":"3.50.1"},"reference-count":51,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Sporotrichosis is an important subcutaneous mycosis, with an increasing worldwide incidence. However, few data are available regarding the immunological aspects of<jats:italic>Sporothrix schenckii<\/jats:italic>infection, particularly the humoral responses to the fungus. In this study we measured immunoglobulin G (IgG), IgM, and IgA in sera from 41 patients with sporotrichosis before antifungal treatment and from another 35 patients with sporotrichosis during itraconazole treatment by using a recently described<jats:italic>S. schenckii<\/jats:italic>exoantigen enzyme-linked immunosorbent assay (ELISA). More than 95% of patients had detectable IgA antibodies, and more than 85% had IgM and IgG antibodies before treatment. The number of patients with IgG antibodies increased to 91% during treatment. Conversely, significantly fewer samples from treated patients were positive for IgM (71%) and IgA (89%). Overall, 78% of patients had detectable levels of all isotypes tested at diagnosis, and this percentage dropped to 62.9% in patients receiving itraconazole. Testing of all three isotypes improved the sensitivity; at least two isotypes were detected in 93% of patients before and 89% after treatment. The reactivity of 94 sera from patients with other diseases and healthy individuals was also tested. Cross-reactivity occurred in 33% of the heterologous sera. Most of them were positive only in one isotype, 8.5% were positive for at least two isotypes, and only one serum (1.1%) was positive for the three isotypes. Antibodies produced during<jats:italic>S. schenckii<\/jats:italic>infection are diverse, and we demonstrate that an exoantigen ELISA for the detection of combinations of IgA, IgG, and IgM antibodies is a highly sensitive and specific diagnostic assay for sporotrichosis.<\/jats:p>","DOI":"10.1128\/cvi.00149-07","type":"journal-article","created":{"date-parts":[[2007,7,19]],"date-time":"2007-07-19T01:31:13Z","timestamp":1184808673000},"page":"1149-1157","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":31,"title":["Immunoglobulins G, M, and A against<i>Sporothrix schenckii<\/i>Exoantigens in Patients with Sporotrichosis before and during Treatment with Itraconazole"],"prefix":"10.1128","volume":"14","author":[{"given":"Rodrigo","family":"Almeida-Paes","sequence":"first","affiliation":[{"name":"Servic\u0327o de Micologia, Instituto de Pesquisa Cli\u0301nica Evandro Chagas-Fundac\u0327a\u0303o Oswaldo Cruz, Rio de Janeiro, Brazil"},{"name":"Division of Infectious Diseases, Department of Medicine"},{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique Amorim","family":"Pimenta","sequence":"additional","affiliation":[{"name":"Servic\u0327o de Micologia, Instituto de Pesquisa Cli\u0301nica Evandro Chagas-Fundac\u0327a\u0303o Oswaldo Cruz, Rio de Janeiro, Brazil"},{"name":"Division of Infectious Diseases, Department of Medicine"},{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Cezar F.","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Servic\u0327o de Micologia, Instituto de Pesquisa Cli\u0301nica Evandro Chagas-Fundac\u0327a\u0303o Oswaldo Cruz, Rio de Janeiro, Brazil"},{"name":"Division of Infectious Diseases, Department of Medicine"},{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua D.","family":"Nosanchuk","sequence":"additional","affiliation":[{"name":"Servic\u0327o de Micologia, Instituto de Pesquisa Cli\u0301nica Evandro Chagas-Fundac\u0327a\u0303o Oswaldo Cruz, Rio de Janeiro, Brazil"},{"name":"Division of Infectious Diseases, Department of Medicine"},{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosely Maria","family":"Zancope\u0301-Oliveira","sequence":"additional","affiliation":[{"name":"Servic\u0327o de Micologia, Instituto de Pesquisa Cli\u0301nica Evandro Chagas-Fundac\u0327a\u0303o Oswaldo Cruz, Rio de Janeiro, Brazil"},{"name":"Division of Infectious Diseases, Department of Medicine"},{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/S0190-9622(99)70093-9","volume":"40","year":"1999","unstructured":"Agudelo, S. P., S. Restrepo, and I. D. Velez. 1999. Cutaneous New World leishmaniasis-sporotrichosis coinfection: report of 3 cases. J. Am. Acad. Dermatol.40:1002-1004.","journal-title":"J. Am. Acad. Dermatol."},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/BF00440950","volume":"85","year":"1984","unstructured":"Albornoz, M. B., E. Villanueva, and E. D. Torres. 1984. Application of immunoprecipitation techniques to the diagnosis of cutaneous and extracutaneous forms of sporotrichosis. Mycopathologia85:177-183.","journal-title":"Mycopathologia"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00430-06"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1046\/j.1365-4362.2001.01295.x","volume":"40","year":"2001","unstructured":"Araujo, T., A. C. Marques, and F. Kerdel. 2001. Sporotrichosis. Int. J. Dermatol.40:737-742.","journal-title":"Int. J. Dermatol."},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S1286-4579(99)80022-7","volume":"1","year":"1999","unstructured":"Baida, H., P. J. Biselli, M. Juvenale, G. M. Del Negro, M. J. Mendes-Giannini, A. J. Duarte, and G. Benard. 1999. Differential antibody isotype expression to the major Paracoccidioides brasiliensis antigen in juvenile and adult form paracoccidioidomycosis. Microbes Infect.1:273-278.","journal-title":"Microbes Infect."},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.actatropica.2004.09.004","volume":"93","year":"2005","unstructured":"Barros, M. B. L., A. Schubach, A. C. Francesconi-do-Valle, M. C. Gutierrez-Galhardo, T. M. Schubach, F. Conceicao-Silva, M. de Matos Salgueiro, E. Mouta-Confort, R. S. Reis, M. Fatima Madeira, T. Cuzzi, L. P. Quintella, J. P. Silva Passos, M. J. Conceicao, and M. C. A. Marzochi. 2005. Positive Montenegro skin test among patients with sporotrichosis in Rio de Janeiro. Acta Trop.93:41-47.","journal-title":"Acta Trop."},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1046\/j.1365-4362.2003.01813.x","volume":"42","year":"2003","unstructured":"Barros, M. B. L., A. O. Schubach, M. C. Galhardo, T. M. Schubach, R. S. dos Reis, M. J. Conceicao, and A. C. F. Valle. 2003. Sporotrichosis with widespread cutaneous lesions: report of 24 cases related to transmission by domestic cats in Rio de Janeiro, Brazil. Int. J. Dermatol.42:677-681.","journal-title":"Int. J. Dermatol."},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1590\/S0074-02762001000600006","volume":"96","year":"2001","unstructured":"Barros, M. B. L., T. M. Schubach, M. C. Galhardo, A. O. Schubach, P. C. Monteiro, R. S. Reis, R. M. Zancope-Oliveira, M. S. Lazera, T. Cuzzi-Maya, T. C. Blanco, K. B. Marzochi, B. Wanke, and A. C. F. Valle. 2001. Sporotrichosis: an emergent zoonosis in Rio de Janeiro. Mem. Inst. Oswaldo Cruz.96:777-779.","journal-title":"Mem. Inst. Oswaldo Cruz."},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1080\/13693780400019909","volume":"43","year":"2005","unstructured":"Bernardes-Engemann, A. R., R. C. Costa, B. R. Miguens, C. V. Penha, E. Neves, B. A. Pereira, C. M. Dias, M. Mattos, M. C. Gutierrez, A. Schubach, M. P. Oliveira Neto, M. Lazera, and L. M. Lopes-Bezerra. 2005. Development of an enzyme-linked immunosorbent assay for the serodiagnosis of several clinical forms of sporotrichosis. Med. Mycol.43:487-493.","journal-title":"Med. Mycol."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/am.26.1.4-8.1973"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1080\/02681219780001161","volume":"35","year":"1997","unstructured":"Bueno, J. P., M. J. Mendes-Giannini, G. M. Del Negro, C. M. Assis, C. K. Takiguti, and M. A. Shikanai-Yasuda. 1997. IgG, IgM and IgA antibody response for the diagnosis and follow-up of paracoccidioidomycosis: comparison of counterimmunoelectrophoresis and complement fixation. J. Med. Vet. Mycol.35:213-217.","journal-title":"J. Med. Vet. Mycol."},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1080\/02681219880000651","volume":"36","year":"1998","unstructured":"Camargo, Z. P., R. G. Baruzzi, S. M. Maeda, and M. C. Floriano. 1998. Antigenic relationship between Loboa loboi and Paracoccidioides brasiliensis as shown by serological methods. Med. Mycol.36:413-417.","journal-title":"Med. Mycol."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.11.4211-4218.1995"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2776(06)91001-3","volume":"91","year":"2006","unstructured":"Casadevall, A., and L. A. Pirofski. 2006. A reappraisal of humoral immunity based on mechanisms of antibody-mediated protection against intracellular pathogens. Adv. Immunol.91:1-44.","journal-title":"Adv. Immunol."},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1080\/00362178385380461","volume":"21","year":"1983","unstructured":"Casserone, S., I. A. Conti-Diaz, E. Zanetta, and M. E. P. Pereira. 1983. Serologia de la esporotricosis cut\u00e2nea. Sabouraudia21:317-321.","journal-title":"Sabouraudia"},{"key":"e_1_3_2_17_2","first-page":"92","volume":"24","year":"1981","unstructured":"Castro, R. M., M. F. Sabogal, L. C. Cuce, and A. Salebian. 1981. Disseminate sporotrichosis: report of a clinical case with mucocutaneous, osteo-articular, and ocular lesions. Mykosen24:92-96.","journal-title":"Mykosen"},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1128\/CDLI.12.9.1063-1068.2005","volume":"12","year":"2005","unstructured":"Chaturvedi, A. K., A. Kavishwar, G. B. Shiva Keshava, and P. K. Shukla. 2005. Monoclonal immunoglobulin G1 directed against Aspergillus fumigatus cell wall glycoprotein protects against experimental murine aspergillosis. Clin. Diagn. Lab. Immunol.12:1063-1068.","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/BF00436061","volume":"108","year":"1989","unstructured":"Conti Diaz, I. A. 1989. Epidemiology of sporotrichosis in Latin America. Mycopathologia108:113-116.","journal-title":"Mycopathologia"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.29.6.1106-1113.1991"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.7.3.497-500.2000"},{"key":"e_1_3_2_22_2","first-page":"137","volume":"7","year":"1997","unstructured":"Esterre, P., M. Jahevitra, E. Ramarcel, and A. Adriantsimahavandy. 1997. Evaluation of the ELISA technique for the diagnosis and the seroepidemiology of chromoblastomycosis. J. Mycol. Med.7:137-141.","journal-title":"J. Mycol. Med."},{"key":"e_1_3_2_23_2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0167-5877(00)00115-X","volume":"45","year":"2000","unstructured":"Greiner, M., D. Pfeiffer, and R. D. Smith. 2000. Principles and practical application of the receiver-operating characteristic analysis for diagnostic tests. Prev. Vet. Med.45:23-41.","journal-title":"Prev. Vet. Med."},{"key":"e_1_3_2_24_2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0022-1759(95)00121-P","volume":"185","year":"1995","unstructured":"Greiner, M., D. Sohr, and P. Gobel. 1995. A modified ROC analysis for the selection of cut-off values and the definition of intermediate results of serodiagnostic tests. J. Immunol. Methods185:123-132.","journal-title":"J. Immunol. Methods"},{"key":"e_1_3_2_25_2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/BF01103063","volume":"127","year":"1994","unstructured":"Hamouda, T., C. D. Jeffries, E. M. Ekladios, A. M. el-Mishad, M. el-Koomy, and N. Saleh. 1994. Class-specific antibody in human dermatophytosis reactive with Trichophyton rubrum derived antigen. Mycopathologia127:83-88.","journal-title":"Mycopathologia"},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1097\/00003226-200211000-00021","volume":"21","year":"2002","unstructured":"Hampton, D. E., A. Adesina, and J. Chodosh. 2002. Conjunctival sporotrichosis in the absence of antecedent trauma. Cornea21:831-833.","journal-title":"Cornea"},{"key":"e_1_3_2_27_2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jinf.2004.07.001","volume":"51","year":"2005","unstructured":"Hardman, S., I. Stephenson, D. R. Jenkins, M. J. Wiselka, and E. M. Johnson. 2005. Disseminated Sporothrix schenckii in a patient with AIDS. J. Infect.51:73-77.","journal-title":"J. Infect."},{"key":"e_1_3_2_28_2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF00562591","volume":"73","year":"1981","unstructured":"Ishizaki, H., Y. Nakamura, and R. W. Wheat. 1981. Serological cross-reactivity between Sporothrix schenckii and various unrelated fungi. Mycopathologia73:65-68.","journal-title":"Mycopathologia"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.21.2.585-593.1978"},{"key":"e_1_3_2_30_2","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1093\/infdis\/121.3.316","volume":"121","year":"1970","unstructured":"Karlin, J. V., and H. S. Nielsen, Jr. 1970. Serologic aspects of sporotrichosis. J. Infect. Dis.121:316-327.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.9.1.34"},{"key":"e_1_3_2_32_2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1590\/S0001-37652006000200009","volume":"78","year":"2006","unstructured":"Lopes-Bezerra, L. M., A. O. Schubach, and R. O. Costa. 2006. Sporothrix schenckii and sporotrichosis. An. Acad. Bras. Cienc.78:293-308.","journal-title":"An. Acad. Bras. Cienc."},{"key":"e_1_3_2_33_2","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1001\/jama.1970.03180020083018","volume":"214","year":"1970","unstructured":"Manhart, J. W., J. A. Wilson, and B. C. Korbitz. 1970. Articular and cutaneous sporotrichosis. JAMA214:365-367.","journal-title":"JAMA"},{"key":"e_1_3_2_34_2","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1080\/mmy.40.5.447.454","volume":"40","year":"2002","unstructured":"Mendoza, M., A. M. Diaz, M. B. Hung, E. A. Zambrano, E. Diaz, and M. C. Albornoz. 2002. Production of culture filtrates of Sporothrix schenckii in diverse culture media. Med. Mycol.40:447-454.","journal-title":"Med. Mycol."},{"key":"e_1_3_2_35_2","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1046\/j.1365-2230.2002.01087.x","volume":"27","year":"2002","unstructured":"Morris-Jones, R. 2002. Sporotrichosis. Clin. Exp. Dermatol.27:427-431.","journal-title":"Clin. Exp. Dermatol."},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.16.2.547-549.1977"},{"key":"e_1_3_2_37_2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.femsim.2004.08.004","volume":"43","year":"2005","unstructured":"Nascimento, R. C., and S. R. Almeida. 2005. Humoral immune response against soluble and fractionate antigens in experimental sporotrichosis. FEMS Immunol. Med. Microbiol.43:241-247.","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"e_1_3_2_38_2","doi-asserted-by":"crossref","first-page":"435","DOI":"10.2174\/1566524054022530","volume":"5","year":"2005","unstructured":"Nosanchuk, J. D. 2005. Protective antibodies and endemic dimorphic fungi. Curr. Mol. Med.5:435-442.","journal-title":"Curr. Mol. Med."},{"key":"e_1_3_2_39_2","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1172\/JCI19361","volume":"112","year":"2003","unstructured":"Nosanchuk, J. D., J. N. Steenbergen, L. Shi, G. S. Deepe, Jr., and A. Casadevall. 2003. Antibodies to a cell surface histone-like protein protect against Histoplasma capsulatum. J. Clin. Investig.112:1164-1175.","journal-title":"J. Clin. Investig."},{"key":"e_1_3_2_40_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/mmy.38.s1.1.8","volume":"38","year":"2000","unstructured":"Penha, C. V., and L. M. Bezerra. 2000. Concanavalin A-binding cell wall antigens of Sporothrix schenckii: a serological study. Med. Mycol.38:1-7.","journal-title":"Med. Mycol."},{"key":"e_1_3_2_41_2","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0934-8840(96)80001-6","volume":"284","year":"1996","unstructured":"Pirofski, L. A., and A. Casadevall. 1996. Cryptococcus neoformans: paradigm for the role of antibody immunity against fungi? Zentbl. Bakteriol.284:475-495.","journal-title":"Zentbl. Bakteriol."},{"key":"e_1_3_2_42_2","doi-asserted-by":"crossref","first-page":"8017","DOI":"10.4049\/jimmunol.174.12.8017","volume":"174","year":"2005","unstructured":"Rivera, J., and A. Casadevall. 2005. Mouse genetic background is a major determinant of isotype-related differences for antibody-mediated protective efficacy against Cryptococcus neoformans. J. Immunol.174:8017-8026.","journal-title":"J. Immunol."},{"key":"e_1_3_2_43_2","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/01.ico.0000151504.26695.3e","volume":"24","year":"2005","unstructured":"Schubach, A., M. B. de Lima Barros, T. M. Schubach, A. C. Francesconi-do-Valle, M. C. Gutierrez-Galhardo, M. Sued, M. de Matos Salgueiro, P. C. Fialho-Monteiro, R. S. Reis, K. B. Marzochi, B. Wanke, and F. Conceicao-Silva. 2005. Primary conjunctival sporotrichosis: two cases from a zoonotic epidemic in Rio de Janeiro, Brazil. Cornea24:491-493.","journal-title":"Cornea"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.27.2.300-304.1989"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.51.1.6-9.1986"},{"key":"e_1_3_2_46_2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1080\/13693780500035904","volume":"43","year":"2005","unstructured":"Silva-Vergara, M. L., F. R. Maneira, R. M. Oliveira, C. T. Santos, R. M. Etchebehere, and S. J. Adad. 2005. Multifocal sporotrichosis with meningeal involvement in a patient with AIDS. Med. Mycol.43:187-190.","journal-title":"Med. Mycol."},{"key":"e_1_3_2_47_2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1023\/A:1006811704850","volume":"139","year":"1997","unstructured":"Silva, V., O. Fischman, and Z. P. Camargo. 1997. Humoral immune response to Malassezia furfur in patients with pityriasis versicolor and seborrheic dermatitis. Mycopathologia139:79-85.","journal-title":"Mycopathologia"},{"key":"e_1_3_2_48_2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1001\/archderm.1981.01650030021011","volume":"117","year":"1981","unstructured":"Smith, P. W., G. W. Loomis, J. L. Luckasen, and R. K. Osterholm. 1981. Disseminated cutaneous sporotrichosis: three illustrative cases. Arch. Dermatol.117:143-144.","journal-title":"Arch. Dermatol."},{"key":"e_1_3_2_49_2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/BF00436994","volume":"84","year":"1983","unstructured":"Takata, M., and H. Ishizaki. 1983. Correlations among culture times, sugar composition and biological activities of Sporothrix schenckii antigens. Mycopathologia84:31-39.","journal-title":"Mycopathologia"},{"key":"e_1_3_2_50_2","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1080\/mmy.39.4.373.377","volume":"39","year":"2001","unstructured":"Valle, A. C. F., R. L. Costa, P. C. Fialho Monteiro, J. Von Helder, M. M. Muniz, and R. M. Zancope-Oliveira. 2001. Interpretation and clinical correlation of serological tests in paracoccidioidomycosis. Med. Mycol.39:373-377.","journal-title":"Med. Mycol."},{"key":"e_1_3_2_51_2","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.4049\/jimmunol.177.3.1997","volume":"177","year":"2006","unstructured":"van de Sande, W. W., D. J. Janse, V. Hira, H. Goedhart, R. van der Zee, A. O. Ahmed, A. Ott, H. Verbrugh, and A. van Belkum. 2006. Translationally controlled tumor protein from Madurella mycetomatis, a marker for tumorous mycetoma progression. J. Immunol.177:1997-2005.","journal-title":"J. Immunol."},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/cdli.1.4.390-393.1994"}],"container-title":["Clinical and Vaccine Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00149-07","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00149-07","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T23:36:02Z","timestamp":1629416162000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/CVI.00149-07"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":51,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["10.1128\/CVI.00149-07"],"URL":"https:\/\/doi.org\/10.1128\/cvi.00149-07","relation":{},"ISSN":["1556-6811","1556-679X"],"issn-type":[{"value":"1556-6811","type":"print"},{"value":"1556-679X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9]]},"assertion":[{"value":"2007-04-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-07-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}