{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:44:17Z","timestamp":1790700257698,"version":"4.1.0"},"reference-count":19,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The canine parasite\n            <jats:italic>Dirofilaria immitis<\/jats:italic>\n            can infect humans. Patients with pulmonary dirofilariosis develop significantly higher thromboxane B2 levels than healthy individuals living in areas where dirofilariosis is endemic and in areas where dirofilariosis is not endemic. The possible role of\n            <jats:italic>Wolbachia<\/jats:italic>\n            bacteria in the appearance of this eicosanoid is discussed.\n          <\/jats:p>","DOI":"10.1128\/cvi.00197-06","type":"journal-article","created":{"date-parts":[[2006,10,6]],"date-time":"2006-10-06T20:24:23Z","timestamp":1160166263000},"page":"1175-1176","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["High Levels of Serum Thromboxane B2 Are Generated during Human Pulmonary Dirofilariosis"],"prefix":"10.1128","volume":"13","author":[{"given":"R.","family":"Morcho\u0301n","sequence":"first","affiliation":[{"name":"Laboratorio de Parasitologi\u0301a, Facultad de Farmacia, Universidad de Salamanca, Avda. Campo Charro s\/n 37007 Salamanca, Spain"},{"name":"Instituto Reina Sofia de Investigacio\u0301n Nefrolo\u0301gica, Departamento de Fisiologi\u0301a y Farmacologi\u0301a, Universidad de Salamanca, Campus Miguel de Unamuno 37007, Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lo\u0301pez-Belmonte","sequence":"additional","affiliation":[{"name":"Laboratorio de Parasitologi\u0301a, Facultad de Farmacia, Universidad de Salamanca, Avda. Campo Charro s\/n 37007 Salamanca, Spain"},{"name":"Instituto Reina Sofia de Investigacio\u0301n Nefrolo\u0301gica, Departamento de Fisiologi\u0301a y Farmacologi\u0301a, Universidad de Salamanca, Campus Miguel de Unamuno 37007, Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Rodri\u0301guez-Barbero","sequence":"additional","affiliation":[{"name":"Laboratorio de Parasitologi\u0301a, Facultad de Farmacia, Universidad de Salamanca, Avda. Campo Charro s\/n 37007 Salamanca, Spain"},{"name":"Instituto Reina Sofia de Investigacio\u0301n Nefrolo\u0301gica, Departamento de Fisiologi\u0301a y Farmacologi\u0301a, Universidad de Salamanca, Campus Miguel de Unamuno 37007, Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Simo\u0301n","sequence":"additional","affiliation":[{"name":"Laboratorio de Parasitologi\u0301a, Facultad de Farmacia, Universidad de Salamanca, Avda. Campo Charro s\/n 37007 Salamanca, Spain"},{"name":"Instituto Reina Sofia de Investigacio\u0301n Nefrolo\u0301gica, Departamento de Fisiologi\u0301a y Farmacologi\u0301a, Universidad de Salamanca, Campus Miguel de Unamuno 37007, Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"116","volume":"12","year":"1986","unstructured":"Ball, H. A., J. A. Cook, W. C. Wise, and P. V. Halushka. 1986. Role of thromboxane, prostaglandins and leukotrienes in endotoxic. Intensive Care Med.12:116-126.","journal-title":"Intensive Care Med."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1998.0591"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S1286-4579(00)01269-7","volume":"2","year":"2000","unstructured":"Brattig, N. W., U. Rathjens, M. Ernst, F. Geisinger, A. Renz, and F. W. Tischendorf. 2000. Lipopolysaccharide-like molecules derived from Wolbachia endobacteria of the filaria Onchocerca volvulus are candidate mediators in the sequence of inflammatory and antiinflammatory responses of human monocytes. Microbes Infect.2:1147-1157.","journal-title":"Microbes Infect."},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.micinf.2005.10.014","volume":"8","year":"2006","unstructured":"Brattig, N. W., A. Schwohl, R. Rickert, and D. W. Buttner. 2006. The filarial parasite Onchocerca volvulus generates the lipid mediator prostaglandin E2. Microbes Infect.8:873-879.","journal-title":"Microbes Infect."},{"key":"e_1_3_2_6_2","first-page":"437","volume":"70","year":"1992","unstructured":"Cordero, M., A. Muro, F. Simon, J. I. Tapia, and E. Espinoza. 1992. Are transient pulmonary solitary nodules a common event in human dirofilariosis? Clin. Investig.70:437-440.","journal-title":"Clin. Investig."},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1164\/ajrccm.156.6.9706026","volume":"156","year":"1997","unstructured":"Davi, G., S. Basili, M. Vieri, F. Cipollone, S. Santarone, C. Alessandri, P. Gazzaniga, C. Cordova, F. Violi, et al. 1997. Enhanced thromboxane biosynthesis in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med.156:1794-1799.","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"e_1_3_2_8_2","first-page":"p","year":"2001","unstructured":"Genchi, C., L. H. Kramer, and G. Prieto. 2001. Epidemiology of canine and feline dirofilariosis. A global view, p. 121-129. In F. Sim\u00f3n and C. Genchi (ed.), Heartworm infection in humans and animals. Ediciones Universidad de Salamanca, Salamanca, Spain.","journal-title":"Heartworm infection in humans and animals"},{"key":"e_1_3_2_9_2","first-page":"79","volume":"48","year":"2002","unstructured":"Hirano, H., T. Kizaki, T. Sashikata, and T. Matsumura. 2002. Pulmonary dirofilariosis\u2014clinicopathological study. Kobe J. Med. Sci.48:79-86.","journal-title":"Kobe J. Med. Sci."},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.vetimm.2005.03.011","volume":"106","year":"2005","unstructured":"Kramer, L. H., F. Tamarozzi, R. Morch\u00f3n, J. L\u00f3pez-Belmonte, C. Marcos-Atxutegi, J. R. Mart\u00edn-Pacho, and F. Sim\u00f3n. 2005. Immune response to and tissue localization of the Wolbachia surface protein (WSP) in dogs with natural heartworm (Dirofilaria immitis) infection. Vet. Immunol. Immunopathol.106:303-308.","journal-title":"Vet. Immunol. Immunopathol."},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/0014-4894(90)90076-O","volume":"71","year":"1990","unstructured":"Liu, L. X., and P. F. Weller. 1990. Arachidonic acid metabolism in filarial parasites. Exp. Parasitol.71:496-501.","journal-title":"Exp. Parasitol."},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1084\/jem.172.3.993","volume":"172","year":"1990","unstructured":"Liu, L. X., C. N. Serhan, and P. F. Weller. 1990. Intravascular filarial parasites elaborate cyclooxygenase-derived eicosanoids. J. Exp. Med.172:993-996.","journal-title":"J. Exp. Med."},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"520","DOI":"10.4269\/ajtmh.1992.46.520","volume":"46","year":"1992","unstructured":"Liu, L. X., J. E. Buhlmann, and P. F. Weller. 1992. Release of prostaglandin E2 by microfilariae of Wuchereria bancrofti and Brugia malayi. Am. J. Trop. Med. Hyg.46:520-523.","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1093\/infdis\/152.6.1317","volume":"152","year":"1985","unstructured":"Longworth, D. L., D. W. Foster, A. M. Dvorak, and P. F. Weller. 1985. Incorporation of arachidonic acid by microfilariae of Brugia malayi. J. Infect. Dis.152:1317-1323.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/S0169-4758(99)01496-9","volume":"15","year":"1999","unstructured":"Muro, A., C. Genchi, M. Cordero, and F. Sim\u00f3n. 1999. Human dirofilariasis in the European Union. Parasitol. Today15:386-389.","journal-title":"Parasitol. Today"},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1378\/chest.61.1.51","volume":"61","year":"1972","unstructured":"Navarrete, A. R. 1972. Pulmonary dirofilariasis. Chest61:51-54.","journal-title":"Chest"},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/00007611-197404000-00019","volume":"67","year":"1974","unstructured":"Robinson, M. J., M. Viamonte, and M. Viamonte. 1974. Dirolilariosis: diagnostic consideration for pulmonary coin lesions. South. Med. J.67:461.","journal-title":"South. Med. J."},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1006\/bbrc.2001.4865","volume":"283","year":"2001","unstructured":"Sala, A., and F. Gincarlo. 2001. Neutrophils, endothelial cells, and cysteinyl leukotrienes: a new approach to neutrophil-dependent inflammation? Biochem. Biophys. Res. Commun.283:1003-1006.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"e_1_3_2_19_2","first-page":"180","volume":"10","year":"2003","unstructured":"Simon, F., G. Prieto, R. Morchon, C. Bazzocchi, C. Bandi, and C. Genchi. 2003. Immunoglobulin G antibodies against the endosymbionts of filarial nematodes (Wolbachia) in patients with pulmonary dirofilariasis. Clin. Diagn. Lab. Immunol.10:180-181.","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"e_1_3_2_20_2","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1046\/j.1365-3024.2001.00400.x","volume":"23","year":"2001","unstructured":"Taylor, M. J., H. F. Cross, L. Ford, W. H. Makunde, G. B. K. S. Prasad, and K. Bilo. 2001. Wolbachia bacteria in filarial immunity and disease. Parasitol. Immunol.23:401-409.","journal-title":"Parasitol. Immunol."}],"container-title":["Clinical and Vaccine Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00197-06","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00197-06","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T20:36:31Z","timestamp":1627590991000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/CVI.00197-06"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":19,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["10.1128\/CVI.00197-06"],"URL":"https:\/\/doi.org\/10.1128\/cvi.00197-06","relation":{},"ISSN":["1556-6811","1556-679X"],"issn-type":[{"value":"1556-6811","type":"print"},{"value":"1556-679X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10]]},"assertion":[{"value":"2006-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-07-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}