{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:32:51Z","timestamp":1791304371470,"version":"4.3.1"},"reference-count":25,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>Uveitis can be a serious complication of leptospirosis. Previous studies indicated that the leptospiral lipoproteins LruA and LruB are expressed in the eyes of uveitic horses and that antibodies directed against those proteins show in vitro cross-reactivity with components of equine lens, ciliary body, and\/or retina. We now demonstrate that sera from a significant proportion of humans who have leptospiral uveitis also contain antibodies against LruA and LruB. Different categories of nonleptospiral uveitis and autoimmune uveitis were also screened; patients diagnosed with Fuchs uveitis or Behc\u0327et's syndrome produced antibodies that cross-reacted with LruA and LruB, suggesting similarities of the autoimmune responses in those diseases with those of leptospiral uveitis.<\/jats:p>","DOI":"10.1128\/cvi.00203-07","type":"journal-article","created":{"date-parts":[[2008,4,10]],"date-time":"2008-04-10T01:41:50Z","timestamp":1207791710000},"page":"1019-1023","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":41,"title":["LruA and LruB Antibodies in Sera of Humans with Leptospiral Uveitis"],"prefix":"10.1128","volume":"15","author":[{"given":"Ashutosh","family":"Verma","sequence":"first","affiliation":[{"name":"M. H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, Kentucky 40546"},{"name":"Uvea Clinic, Aravind Eye Hospital, No. 1, Anna Nagar, Madurai 625 020, Tamil Nadu, India"},{"name":"Aravind Medical Research Foundation, No. 1, Anna Nagar, Madurai 625 020, Tamil Nadu, India"},{"name":"Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, College of Medicine, Lexington, Kentucky 40536"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. R.","family":"Rathinam","sequence":"additional","affiliation":[{"name":"M. H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, Kentucky 40546"},{"name":"Uvea Clinic, Aravind Eye Hospital, No. 1, Anna Nagar, Madurai 625 020, Tamil Nadu, India"},{"name":"Aravind Medical Research Foundation, No. 1, Anna Nagar, Madurai 625 020, Tamil Nadu, India"},{"name":"Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, College of Medicine, Lexington, Kentucky 40536"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Gowri","family":"Priya","sequence":"additional","affiliation":[{"name":"M. H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, Kentucky 40546"},{"name":"Uvea Clinic, Aravind Eye Hospital, No. 1, Anna Nagar, Madurai 625 020, Tamil Nadu, India"},{"name":"Aravind Medical Research Foundation, No. 1, Anna Nagar, Madurai 625 020, Tamil Nadu, India"},{"name":"Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, College of Medicine, Lexington, Kentucky 40536"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. R.","family":"Muthukkaruppan","sequence":"additional","affiliation":[{"name":"M. H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, Kentucky 40546"},{"name":"Uvea Clinic, Aravind Eye Hospital, No. 1, Anna Nagar, Madurai 625 020, Tamil Nadu, India"},{"name":"Aravind Medical Research Foundation, No. 1, Anna Nagar, Madurai 625 020, Tamil Nadu, India"},{"name":"Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, College of Medicine, Lexington, Kentucky 40536"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Stevenson","sequence":"additional","affiliation":[{"name":"M. H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, Kentucky 40546"},{"name":"Uvea Clinic, Aravind Eye Hospital, No. 1, Anna Nagar, Madurai 625 020, Tamil Nadu, India"},{"name":"Aravind Medical Research Foundation, No. 1, Anna Nagar, Madurai 625 020, Tamil Nadu, India"},{"name":"Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, College of Medicine, Lexington, Kentucky 40536"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Timoney","sequence":"additional","affiliation":[{"name":"M. H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, Kentucky 40546"},{"name":"Uvea Clinic, Aravind Eye Hospital, No. 1, Anna Nagar, Madurai 625 020, Tamil Nadu, India"},{"name":"Aravind Medical Research Foundation, No. 1, Anna Nagar, Madurai 625 020, Tamil Nadu, India"},{"name":"Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, College of Medicine, Lexington, Kentucky 40536"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1177\/154405910508400302","volume":"84","year":"2005","unstructured":"Al-Otaibi, L. M., S. R. Porter, and T. W. J. Poate. 2005. Beh\u00e7et's disease: a review. J. Dent. Res.84:209-222.","journal-title":"J. Dent. Res."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.2.742-749.2004"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1001\/archopht.1981.03930010435007","volume":"99","year":"1981","unstructured":"Boger, W. P., R. A. Petersen, and R. M. Robb. 1981. Spontaneous absorption of the lens in the congenital rubella syndrome. Arch. Ophthalmol.99:433-434.","journal-title":"Arch. Ophthalmol."},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1080\/08820530500231995","volume":"20","year":"2005","unstructured":"Bonfioli, A. A., A. L. Curi, and F. Orefice. 2005. Fuchs' heterochromic cyclitis. Semin. Ophthalmol.20:143-146.","journal-title":"Semin. Ophthalmol."},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1001\/archopht.118.6.800","volume":"118","year":"2000","unstructured":"Chowers, I., E. Zamir, E. Banin, and S. Merin. 2000. Retinitis pigmentosa associated with Fuch's heterochromic uveitis. Arch. Ophthalmol.118:800-802.","journal-title":"Arch. Ophthalmol."},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1086\/515273","volume":"177","year":"1998","unstructured":"Chu, K. M., R. Rathinam, P. Namperumalsamy, and D. Dean. 1998. Identification of Leptospira species in the pathogenesis of uveitis and determination of clinical ocular characteristics in south India. J. Infect. Dis.177:1314-1321.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/am.25.6.976-980.1973"},{"key":"e_1_3_2_9_2","first-page":"273","year":"2002","unstructured":"Dana, M. R. 2002. Leptospirosis, p. 273-277. In C. S. Foster and A. T. Vitale (ed.), Diagnosis and treatment of uveitis. W. B. Saunders, Philadelphia, PA.","journal-title":"Diagnosis and treatment of uveitis."},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"R71","DOI":"10.1186\/ar1940","volume":"8","year":"2006","unstructured":"Delunardo, F., F. Conti, P. Margutti, C. Alessandri, R. Priori, A. Siracusano, R. Rigan\u00f2, E. Profumo, G. Valesini, M. Sorice, and E. Ortona. 2006. Identification and characterization of the carboxy-terminal region of Sip-1, a novel autoantigen in Beh\u00e7et's disease. Arthritis Res. Ther.8:R71.","journal-title":"Arthritis Res. Ther."},{"key":"e_1_3_2_11_2","first-page":"285","year":"2005","unstructured":"Dwyer, A. E., and B. C. Gilger. 2005. Equine recurrent uveitis, p. 285-322. In B. C. Gilger (ed.), Equine ophthalmology. W.B. Saunders Co., Philadelphia, PA.","journal-title":"Equine ophthalmology."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.9.3303-3310.2001"},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.3109\/02713688509003348","volume":"4","year":"1985","unstructured":"Halliwell, R. E., T. A. Brim, M. T. Hines, D. Wolf, and F. H. White. 1985. Studies on equine recurrent uveitis. II. The role of infection with Leptospira interrogans serovar Pomona. Curr. Eye Res.4:1033-1040.","journal-title":"Curr. Eye Res."},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1439-0450.2004.00740.x","volume":"51","year":"2004","unstructured":"Hartskeerl, R. A., M. G. Goris, S. Brem, P. Meyer, H. Kopp, H. Gerhards, and B. Wollanke. 2004. Classification of leptospira from the eyes of horses suffering from recurrent uveitis. J. Vet. Med. B51:110-115.","journal-title":"J. Vet. Med. B"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1136\/bjo.77.7.436","volume":"77","year":"1993","unstructured":"La Hey, E., L. Broersma, R. van der Gaag, G. S. Baarsma, A. Rothova, and A. Kijlstra. 1993. Does autoimmunity to S-antigen play a role in Fuchs' heterochromic cyclitis? Br. J. Ophthalmol.77:436-439.","journal-title":"Br. J. Ophthalmol."},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"R1133","DOI":"10.1186\/ar1798","volume":"7","year":"2005","unstructured":"Lu, Y., P. Ye, S. Chen, E. M. Tan, and E. K. L. Chan. 2005. Identification of kinectin as a novel Beh\u00e7et's disease autoantigen. Arthritis Res. Ther.7:R1133-R1139.","journal-title":"Arthritis Res. Ther."},{"key":"e_1_3_2_17_2","first-page":"283","volume":"50","year":"1952","unstructured":"Marlow, S. B. 1952. Spontaneous absorption of cataract. Trans. Am. Ophthalmol. Soc.50:283-293.","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1076\/ocii.6.2.75.4045","volume":"6","year":"1998","unstructured":"Martins, M. G., K. T. F Matos, M. V. da Silva, and M. T. de Abreu. 1998. Ocular manifestations in the acute phase of leptospirosis. Ocul. Immunol. Inflamm.6:75-79.","journal-title":"Ocul. Immunol. Inflamm."},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1099\/jmm.0.45568-0","volume":"53","year":"2004","unstructured":"Palaniappan, R. U. M., Y. F. Chang, F. Hassan, S. P. McDonough, M. Pough, S. C. Barr, K. W. Simpson, H. O. Mohammed, S. Shin, P. McDonough, R. L. Zuerner, J. Qu, and B. Roe. 2004. Expression of leptospiral immunoglobulin-like protein by Leptospira interrogans and evaluation of its diagnostic potential in a kinetic ELISA. Med. Microbiol.53:975-984.","journal-title":"Med. Microbiol."},{"key":"e_1_3_2_20_2","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1099\/jmm.0.05120-0","volume":"52","year":"2003","unstructured":"Priya, C. G., K. Bhavani, S. R. Rathinam, and V. R. Muthukkaruppan. 2003. Identification and evaluation of LPS antigen for serodiagnosis of uveitis associated with leptospirosis. J. Med. Microbiol.52:667-673.","journal-title":"J. Med. Microbiol."},{"key":"e_1_3_2_21_2","first-page":"189","volume":"51","year":"2005","unstructured":"Rathinam, S. R. 2005. Ocular manifestations of leptospirosis. J. Postgrad. Med.51:189-194.","journal-title":"J. Postgrad. Med."},{"key":"e_1_3_2_22_2","unstructured":"Studies on clinical presentation diagnosis and management of infectious uveitis with reference to leptospirosis. 2006"},{"key":"e_1_3_2_23_2","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1136\/bjo.84.10.1135","volume":"84","year":"2000","unstructured":"Rathinam, S. R., P. Namperumalsamy, and E. T. Cunningham, Jr. 2000. Spontaneous cataract absorption in patients with leptospiral uveitis. Br. J. Ophthalmol.84:1135-1141.","journal-title":"Br. J. Ophthalmol."},{"key":"e_1_3_2_24_2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0002-9394(14)71646-0","volume":"124","year":"1997","unstructured":"Rathinam, S. R., S. Rathnam, S. Selvaraj, D. Dean, R. A. Nozik, and P. Namperumalsamy. 1997. Uveitis associated with an epidemic outbreak of leptospirosis. Am. J. Ophthalmol.124:71-79.","journal-title":"Am. J. Ophthalmol."},{"key":"e_1_3_2_25_2","first-page":"443","volume":"30","year":"1989","unstructured":"van der Gaag, R., L. Broersma, A. Rothova, S. Baarsma, and A. Kijlstra. 1989. Immunity to a corneal antigen in Fuchs' heterochromic cyclitis patients. Investig. Ophthalmol. Vis. Sci.30:443-448.","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.11.7259-7266.2005"}],"container-title":["Clinical and Vaccine Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00203-07","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00203-07","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T20:40:25Z","timestamp":1627591225000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/CVI.00203-07"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1128\/CVI.00203-07"],"URL":"https:\/\/doi.org\/10.1128\/cvi.00203-07","relation":{},"ISSN":["1556-6811","1556-679X"],"issn-type":[{"value":"1556-6811","type":"print"},{"value":"1556-679X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6]]},"assertion":[{"value":"2007-05-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-04-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}