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Animals were infected with American or Asian DENV-2 strains and challenged 1 year later with a DENV-2 Asian genotype strain. The viremia and monkey antibody levels were similar for the different strains after primary and secondary infection; however, the functionality of the antibody response was different. A limited viral replication was demonstrated after the secondary infection in all the monkeys. No virus was isolated in tissue culture, while reverse transcription-PCR showed a late positive reaction in four of five challenged monkeys. The immunoglobulin M response pattern and the detection of antibodies to specific proteins by Western blotting supported the protection data. Despite the demonstration of the protective effect after homologous challenge, a strong anamnestic antibody response was observed.<\/jats:p>","DOI":"10.1128\/cvi.00208-07","type":"journal-article","created":{"date-parts":[[2007,12,20]],"date-time":"2007-12-20T01:45:26Z","timestamp":1198115126000},"page":"439-446","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":26,"title":["Primary and Secondary Infections of<i>Macaca fascicularis<\/i>Monkeys with Asian and American Genotypes of Dengue Virus 2"],"prefix":"10.1128","volume":"15","author":[{"given":"Lidice","family":"Bernardo","sequence":"first","affiliation":[{"name":"Department of Virology, PAHO\/WHO Collaborating Center for the Study of Dengue and its Vector, Pedro Kouri\u0301 Tropical Medicine Institute, Autopista Novia del Mediodi\u0301a, km 6 1\/2, P.O. 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