{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:01:23Z","timestamp":1773288083354,"version":"3.50.1"},"reference-count":22,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Southern tick-associated rash illness (STARI), also known as Masters disease, affects people predominantly in the Southeast and South Central United States. These patients exhibit skin lesions that resemble erythema migrans (EM), the characteristic skin lesion in early Lyme disease. The etiology of STARI remains unknown, and no serologic test is available to aid in its diagnosis. The C\n            <jats:sub>6<\/jats:sub>\n            Lyme enzyme-linked immunosorbent assay was used to evaluate coded serum specimens from patients with STARI at two laboratory sites. The specimens tested at one site consisted of acute- and convalescent-phase samples that were obtained from nine STARI patients from Missouri and from one patient with documented\n            <jats:italic>Borrelia lonestari<\/jats:italic>\n            infection who acquired this infection in either North Carolina or Maryland. All of these samples were C\n            <jats:sub>6<\/jats:sub>\n            negative. Seventy acute- or convalescent-phase specimens from 63 STARI patients from Missouri were C\n            <jats:sub>6<\/jats:sub>\n            tested at the second site. All but one of these STARI specimens were also negative. In contrast, of nine acute- and nine convalescent-phase serum specimens obtained from culture-confirmed Lyme disease patients with EM from New York state, seven were C\n            <jats:sub>6<\/jats:sub>\n            positive at the acute stage, and eight were positive at convalescence. The C\n            <jats:sub>6<\/jats:sub>\n            test is negative in patients with STARI, providing further evidence that\n            <jats:italic>B. burgdorferi<\/jats:italic>\n            is not the etiologic agent of this disease.\n          <\/jats:p>","DOI":"10.1128\/cvi.00238-06","type":"journal-article","created":{"date-parts":[[2006,10,6]],"date-time":"2006-10-06T20:24:23Z","timestamp":1160166263000},"page":"1170-1171","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["Serologic Evaluation of Patients from Missouri with Erythema Migrans-Like Skin Lesions with the C\n            <sub>6<\/sub>\n            Lyme Test"],"prefix":"10.1128","volume":"13","author":[{"given":"Mario T.","family":"Philipp","sequence":"first","affiliation":[{"name":"Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana"},{"name":"Family Practice of Dr. Edwin Masters, Cape Girardeau, Missouri"},{"name":"Division of Infectious Diseases, Department of Medicine of New York Medical College, Valhalla, New York"},{"name":"Focus Diagnostics, Inc., Cypress, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin","family":"Masters","sequence":"additional","affiliation":[{"name":"Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana"},{"name":"Family Practice of Dr. Edwin Masters, Cape Girardeau, Missouri"},{"name":"Division of Infectious Diseases, Department of Medicine of New York Medical College, Valhalla, New York"},{"name":"Focus Diagnostics, Inc., Cypress, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary P.","family":"Wormser","sequence":"additional","affiliation":[{"name":"Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana"},{"name":"Family Practice of Dr. Edwin Masters, Cape Girardeau, Missouri"},{"name":"Division of Infectious Diseases, Department of Medicine of New York Medical College, Valhalla, New York"},{"name":"Focus Diagnostics, Inc., Cypress, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne","family":"Hogrefe","sequence":"additional","affiliation":[{"name":"Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana"},{"name":"Family Practice of Dr. Edwin Masters, Cape Girardeau, Missouri"},{"name":"Division of Infectious Diseases, Department of Medicine of New York Medical College, Valhalla, New York"},{"name":"Focus Diagnostics, Inc., Cypress, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dale","family":"Martin","sequence":"additional","affiliation":[{"name":"Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana"},{"name":"Family Practice of Dr. Edwin Masters, Cape Girardeau, Missouri"},{"name":"Division of Infectious Diseases, Department of Medicine of New York Medical College, Valhalla, New York"},{"name":"Focus Diagnostics, Inc., Cypress, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1086\/374395","volume":"187","year":"2003","unstructured":"Bacon, R. 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Utility of an in-office C6 ELISA test kit for determination of infection status of dogs naturally exposed to Borrelia burgdorferi. Vet. Ther.3:308-315.","journal-title":"Vet. Ther."},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1086\/315862","volume":"182","year":"2000","unstructured":"Liang, F. T., E. Aberer, M. Cinco, L. Gern, C. M. Hu, Y. N. Lobet, M. Ruscio, P. E. Voet, Jr., V. E. Weynants, and M. T. Philipp. 2000. Antigenic conservation of an immunodominant invariable region of the VlsE lipoprotein among European pathogenic genospecies of Borrelia burgdorferi SL. J. Infect. Dis.182:1455-1462.","journal-title":"J. Infect. 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Comparison of Western immunoblotting and the C6 Lyme antibody test for laboratory detection of Lyme disease. Clin. Diagn. Lab. Immunol.11:924-929.","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1111\/j.1469-0691.2006.01374.x","volume":"12","year":"2006","unstructured":"Nyman, D., L. Willen, C. Jansson, S. A. Carlsson, H. Granlund, and P. Wahlberg. 2006. VlsE C6 peptide and IgG ELISA antibody analysis for clinical diagnosis of Lyme borreliosis in an endemic area. Clin. Microbiol. Infect.12:496-497.","journal-title":"Clin. Microbiol. Infect."},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1007\/s00415-003-0205-2","volume":"250","year":"2003","unstructured":"Panelius, J., P. Lahdenne, H. Saxen, S. A. Carlsson, T. Heikkila, M. Peltomaa, A. Lauhio, and I. Seppala. 2003. 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Dis."}],"container-title":["Clinical and Vaccine Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00238-06","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00238-06","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T20:36:36Z","timestamp":1627590996000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/CVI.00238-06"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":22,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["10.1128\/CVI.00238-06"],"URL":"https:\/\/doi.org\/10.1128\/cvi.00238-06","relation":{},"ISSN":["1556-6811","1556-679X"],"issn-type":[{"value":"1556-6811","type":"print"},{"value":"1556-679X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10]]},"assertion":[{"value":"2006-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-07-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}