{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:49:36Z","timestamp":1790095776635,"version":"4.0.1"},"reference-count":57,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content content-type=\"genus-species\">Chlamydia trachomatis<\/jats:named-content>\n            is the causative agent of the most frequently reported bacterial sexually transmitted infection, the total burden of which is underestimated due to the asymptomatic nature of the infection. Untreated\n            <jats:named-content content-type=\"genus-species\">C. trachomatis<\/jats:named-content>\n            infections can cause significant morbidities, including pelvic inflammatory disease and tubal factor infertility (TFI). The human immune response against\n            <jats:named-content content-type=\"genus-species\">C. trachomatis<\/jats:named-content>\n            , an obligate intracellular bacterium, is poorly characterized but is thought to rely on cell-mediated immunity, with CD4\n            <jats:sup>+<\/jats:sup>\n            and CD8\n            <jats:sup>+<\/jats:sup>\n            T cells implicated in protection. In this report, we present immune profiling data of subjects enrolled in a multicenter study of\n            <jats:named-content content-type=\"genus-species\">C. trachomatis<\/jats:named-content>\n            genital infection. CD4\n            <jats:sup>+<\/jats:sup>\n            and CD8\n            <jats:sup>+<\/jats:sup>\n            T cells from subjects grouped into disease-specific cohorts were screened using a\n            <jats:named-content content-type=\"genus-species\">C. trachomatis<\/jats:named-content>\n            proteomic library to identify the antigen specificities of recall T cell responses after natural exposure by measuring interferon gamma (IFN-\u03b3) levels. We identified specific T cell responses associated with the resolution of infection, including unique antigens identified in subjects who spontaneously cleared infection and different antigens associated with\n            <jats:named-content content-type=\"genus-species\">C. trachomatis<\/jats:named-content>\n            -related sequelae, such as TFI. These data suggest that novel and unique\n            <jats:named-content content-type=\"genus-species\">C. trachomatis<\/jats:named-content>\n            T cell antigens identified in individuals with effective immune responses can be considered as targets for vaccine development, and by excluding antigens associated with deleterious sequelae, immune-mediated pathologies may be circumvented.\n          <\/jats:p>","DOI":"10.1128\/cvi.00247-15","type":"journal-article","created":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T02:18:59Z","timestamp":1444270739000},"page":"1206-1218","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["Resolution of Chlamydia trachomatis Infection Is Associated with a Distinct T Cell Response Profile"],"prefix":"10.1128","volume":"22","author":[{"given":"Michele D.","family":"Picard","sequence":"first","affiliation":[{"name":"Genocea Biosciences, Inc., Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Bodmer","sequence":"additional","affiliation":[{"name":"Genocea Biosciences, Inc., Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd M.","family":"Gierahn","sequence":"additional","affiliation":[{"name":"Genocea Biosciences, Inc., Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Lee","sequence":"additional","affiliation":[{"name":"Genocea Biosciences, Inc., Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Price","sequence":"additional","affiliation":[{"name":"Genocea Biosciences, Inc., Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenya","family":"Cohane","sequence":"additional","affiliation":[{"name":"Genocea Biosciences, Inc., Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Clemens","sequence":"additional","affiliation":[{"name":"Genocea Biosciences, Inc., Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria L.","family":"DeVault","sequence":"additional","affiliation":[{"name":"Genocea Biosciences, Inc., Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galina","family":"Gurok","sequence":"additional","affiliation":[{"name":"Genocea Biosciences, Inc., Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Kohberger","sequence":"additional","affiliation":[{"name":"Blair &amp; Company, LLC, Greenwich, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren E.","family":"Higgins","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George R.","family":"Siber","sequence":"additional","affiliation":[{"name":"Genocea Biosciences, Inc., Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica Baker","family":"Flechtner","sequence":"additional","affiliation":[{"name":"Genocea Biosciences, Inc., Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William M.","family":"Geisler","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham, Birmingham, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","unstructured":"WHO. 2012. 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CDC Grand Rounds: Chlamydia prevention: challenges and strategies for reducing disease burden and sequelae. 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