{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:26:52Z","timestamp":1791023212794,"version":"4.1.0"},"reference-count":42,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Toll-like receptors (TLRs) participate in detecting microbial pattern molecules for activation of the host immune response. We investigated possible roles of TLRs in the chicken response to\n            <jats:italic>Clostridium perfringens<\/jats:italic>\n            infection by examining the expression of TLR genes and other genes involved in TLR-mediated signaling within the spleens and ilea of\n            <jats:italic>C. perfringens<\/jats:italic>\n            -challenged broilers. Upregulation of a tumor necrosis factor alpha-inducing factor homolog in challenged chickens compared to nai\u0308ve chickens was observed, regardless of the incidence of necrotic enteritis. In addition, the members of the TLR2 subfamily were found to be most strongly involved in the host response to\n            <jats:italic>C. perfringens<\/jats:italic>\n            challenge, although the expression of TLR4 and TLR7 was also upregulated in spleen tissues. While the combination of TLR1.2, TLR2.1, and TLR15 appeared to play a major role in the splenic response, the expression of TLR2.2 and TLR1.1 was positively correlated to the expression of adaptor molecules MyD88, TRAF6, TRIF, and receptor interacting protein 1 in the ileal tissues, demonstrating a dynamic spatial and temporal innate host response to\n            <jats:italic>C. perfringens<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1128\/cvi.00254-09","type":"journal-article","created":{"date-parts":[[2009,9,24]],"date-time":"2009-09-24T01:29:02Z","timestamp":1253755742000},"page":"1639-1647","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":63,"title":["Expression Profiles of Genes in Toll-Like Receptor-Mediated Signaling of Broilers Infected with\n            <i>Clostridium perfringens<\/i>"],"prefix":"10.1128","volume":"16","author":[{"given":"Yang","family":"Lu","sequence":"first","affiliation":[{"name":"Laboratory of Gastrointestinal Microbiology, College of Animal Science &amp; Technology, Nanjing Agricultural University, Nanjing, China 210095"},{"name":"Guelph Food Research Centre, Agriculture &amp; Agri-Food Canada, Guelph, Ontario, Canada N1G 5C9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimie J.","family":"Sarson","sequence":"additional","affiliation":[{"name":"Guelph Food Research Centre, Agriculture &amp; Agri-Food Canada, Guelph, Ontario, Canada N1G 5C9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Gong","sequence":"additional","affiliation":[{"name":"Guelph Food Research Centre, Agriculture &amp; Agri-Food Canada, Guelph, Ontario, Canada N1G 5C9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaijun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Poultry Science, Texas A&amp;M University, College Station, Texas 77843"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Laboratory of Gastrointestinal Microbiology, College of Animal Science &amp; Technology, Nanjing Agricultural University, Nanjing, China 210095"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhumei","family":"Kang","sequence":"additional","affiliation":[{"name":"Guelph Food Research Centre, Agriculture &amp; Agri-Food Canada, Guelph, Ontario, Canada N1G 5C9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Yu","sequence":"additional","affiliation":[{"name":"Guelph Food Research Centre, Agriculture &amp; Agri-Food Canada, Guelph, Ontario, Canada N1G 5C9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shayan","family":"Sharif","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Guelph, Guelph, Ontario, Canada N1G 2W1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanming","family":"Han","sequence":"additional","affiliation":[{"name":"Nutreco Canada Agresearch, Guelph, Ontario, Canada N1G 4T2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1089\/vim.2006.19.167","volume":"19","year":"2006","unstructured":"Abdul-Careem, M. F., B. D. Hunter, A. J. Sarson, A. Mayameei, H. Zhou, and S. Sharif. 2006. Marek's disease virus-induced transient paralysis is associated with cytokine gene expression in the nervous system. Viral Immunol.19:167-176.","journal-title":"Viral Immunol."},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3382\/ps.0750329","volume":"75","year":"1996","unstructured":"Arnold, J. W., and P. S. Holt. 1996. Cytotoxicity in chicken alimentary secretions as measured by a derivative of the tumor necrosis factor assay. Poult. Sci.75:329-334.","journal-title":"Poult. Sci."},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1042\/BST0351504","volume":"35","year":"2007","unstructured":"Boyd, A., V. J. Philbin, and A. L. Smith. 2007. Conserved and distinct aspects of the avian Toll-like receptor (TLR) system: implications for transmission and control of bird-borne zoonoses. Biochem. Soc. Trans.35:1504-1507.","journal-title":"Biochem. Soc. Trans."},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"210","DOI":"10.2307\/1593030","volume":"45","year":"2001","unstructured":"Brennan, J., R. Bagg, D. Barnum, J. Wilson, and P. Dick. 2001. Efficacy of narasin in the prevention of necrotic enteritis in broiler chickens. Avian Dis.45:210-214.","journal-title":"Avian Dis."},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1017\/S146625230800145X","volume":"9","year":"2008","unstructured":"Brisbin, J. T., J. Gong, and S. Sharif. 2008. Interactions between commensal bacteria and the gut-associated immune system of the chicken. Anim. Health Res. Rev.9:101-110.","journal-title":"Anim. Health Res. Rev."},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"5423","DOI":"10.1016\/j.vaccine.2008.07.088","volume":"26","year":"2008","unstructured":"Carvajal, B. G., U. Methner, J. Pieper, and A. Berndt. 2008. Effects of Salmonella enterica serovar Enteritidis on cellular recruitment and cytokine gene expression in caecum of vaccinated chickens. Vaccine26:5423-5433.","journal-title":"Vaccine"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.vetimm.2007.10.014","volume":"122","year":"2008","unstructured":"Collier, C. T., C. L. Hofacre, A. M. Payne, D. B. Anderson, P. Kaiser, R. I. Mackie, and H. R. Gaskins. 2008. Coccidia-induced mucogenesis promotes the onset of necrotic enteritis by supporting Clostridium perfringens growth. Vet. Immunol. Immunopathol.122:104-115.","journal-title":"Vet. Immunol. Immunopathol."},{"key":"e_1_3_2_9_2","unstructured":"2nd opinion on anti-microbial resistance 2001"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.3.1692-1698.2006"},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.dci.2007.05.003","volume":"32","year":"2008","unstructured":"Higuchi, M., A. Matsuo, M. Shingai, K. Shida, A. Ishii, K. Funami, Y. Suzuki, H. Oshiumi, M. Matsumoto, and T. Seya. 2008. Combinational recognition of bacterial lipoproteins and peptidoglycan by chicken Toll-like receptor 2 subfamily. Dev. Comp. Immunol.32:147-155.","journal-title":"Dev. Comp. Immunol."},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.dci.2005.12.007","volume":"30","year":"2006","unstructured":"Hong, Y. H., H. S. Lillehoj, S. H. Lee, D. W. Park, and E. P. Lillehoj. 2006. Molecular cloning and characterization of chicken lipopolysaccharide-induced TNF-alpha factor (LITAF). Dev. Comp. Immunol.30:919-929.","journal-title":"Dev. Comp. Immunol."},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.vetimm.2006.07.007","volume":"114","year":"2006","unstructured":"Hong, Y. H., H. S. Lillehoj, S. H. Lee, R. A. Dalloul, and E. P. Lillehoj. 2006. Analysis of chicken cytokine and chemokine gene expression following Eimeria acervulina and Eimeria tenella infections. Vet. Immunol. Immunopathol.114:209-223.","journal-title":"Vet. Immunol. Immunopathol."},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/S0016-5085(99)70182-4","volume":"116","year":"1999","unstructured":"Kaiser, G. C., F. Yan, and D. B. Polk. 1999. Mesalamine blocks tumor necrosis factor growth inhibition and nuclear factor \u03baB activation in mouse colonocytes. Gastroenterology116:602-609.","journal-title":"Gastroenterology"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/sj.cdd.4401850","volume":"13","year":"2006","unstructured":"Kawai, T., and S. Akira. 2006. TLR signaling. Cell Death Differ.13:816-825.","journal-title":"Cell Death Differ."},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"e26","DOI":"10.1371\/journal.ppat.0040026","volume":"4","year":"2008","unstructured":"Keyburn, A. L., J. D. Boyce, P. Vaz, T. L. Bannam, M. E. Ford, D. Parker, A. Di Rubbo, J. I. Rood, and R. J. Moore. 2008. NetB, a new toxin that is associated with avian necrotic enteritis caused by Clostridium perfringens. PLoS Pathog.4:e26.","journal-title":"PLoS Pathog."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00806-06"},{"key":"e_1_3_2_18_2","first-page":"131","volume":"132","year":"2008","unstructured":"Kim, D. K., Y. H. Hong, D. W. Park, S. J. Lamont, and H. S. Lillehoj. 2008. Differential immune-related gene expression in two genetically disparate chicken lines during infection by Eimeria maxima. Dev. Biol. (Basel)132:131-140.","journal-title":"Dev. Biol. (Basel)"},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/emm.2007.47","volume":"39","year":"2007","unstructured":"Krishnan, J., K. Selvarajoo, M. Tsuchiya, G. Lee, and S. Choi. 2007. Toll-like receptor signal transduction. Exp. Mol. Med.39:421-438.","journal-title":"Exp. Mol. Med."},{"key":"e_1_3_2_20_2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000068146","volume":"70","year":"2002","unstructured":"Kucharzik, T., and I. R. Williams. 2002. Neutrophil migration across the intestinal epithelial barrier\u2014summary of in vitro data and description of a new transgenic mouse model with doxycycline-inducible interleukin-8 expression in intestinal epithelial cells. Pathobiology70:143-149.","journal-title":"Pathobiology"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00162-07"},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"4194","DOI":"10.1016\/j.vaccine.2008.05.079","volume":"26","year":"2008","unstructured":"Kulkarni, R. R., V. R. Parreira, S. Sharif, and J. F. Prescott. 2008. Oral immunization of broiler chickens against necrotic enteritis with an attenuated Salmonella vaccine vector expressing Clostridium perfringens antigens. Vaccine26:4194-4203.","journal-title":"Vaccine"},{"key":"e_1_3_2_23_2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/03079450020023230","volume":"30","year":"2001","unstructured":"Lovland, A., and M. Kaldhusdal. 2001. Severely impaired production performance in broiler flocks with high incidence of Clostridium perfringens-associated hepatitis. Avian Pathol.30:73-81.","journal-title":"Avian Pathol."},{"key":"e_1_3_2_24_2","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1079\/WPS200593","volume":"62","year":"2006","unstructured":"McDevitt, R. M., J. D. Brooker, T. Acamovic, and N. H. C. Sparks. 2006. Necrotic enteritis: a continuing challenge for the poultry industry. World's Poult. Sci. J.62:221-247.","journal-title":"World's Poult. Sci. J."},{"key":"e_1_3_2_25_2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00251-008-0346-7","volume":"61","year":"2009","unstructured":"Meade, K. G., F. Narciandi, S. Cahalane, C. Reiman, B. Allan, and C. O'Farrelly. 2009. Comparative in vivo infection models yield insights on early host immune response to Campylobacter in chickens. Immunogenetics61:101-110.","journal-title":"Immunogenetics"},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","first-page":"8611","DOI":"10.1016\/j.vaccine.2007.09.057","volume":"25","year":"2007","unstructured":"Mohammed, J., S. Frasca, Jr., K. Cecchini, D. Rood, A. C. Nyaoke, S. J. Geary, and L. K. Silbart. 2007. Chemokine and cytokine gene expression profiles in chickens inoculated with Mycoplasma gallisepticum strains Rlow or GT5. Vaccine25:8611-8621.","journal-title":"Vaccine"},{"key":"e_1_3_2_27_2","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1038\/bjp.2008.9","volume":"153","year":"2008","unstructured":"Nagahama, M., A. Kihara, H. Kintoh, M. Oda, and J. Sakurai. 2008. Involvement of tumour necrosis factor-alpha in Clostridium perfringens beta-toxin-induced plasma extravasation in mice. Br. J. Pharmacol.153:1296-1302.","journal-title":"Br. J. Pharmacol."},{"key":"e_1_3_2_28_2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00251-008-0340-0","volume":"61","year":"2009","unstructured":"Nerren, J. R., C. L. Swaggerty, K. M. MacKinnon, K. J. Genovese, H. He, I. Pevzner, and M. H. Kogut. 2009. Differential mRNA expression of the avian-specific toll-like receptor 15 between heterophils from Salmonella-susceptible and -resistant chickens. Immunogenetics61:71-77.","journal-title":"Immunogenetics"},{"key":"e_1_3_2_29_2","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.rvsc.2008.02.007","volume":"85","year":"2008","unstructured":"Olkowski, A. A., C. Wojnarowicz, M. Chirino-Trejo, B. Laarveld, and G. Sawicki. 2008. Sub-clinical necrotic enteritis in broiler chickens: novel etiological consideration based on ultra-structural and molecular changes in the intestinal tissue. Res. Vet. Sci.85:543-553.","journal-title":"Res. Vet. Sci."},{"key":"e_1_3_2_30_2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1637\/7997-041707-Reg","volume":"52","year":"2008","unstructured":"Park, S. S., H. S. Lillehoj, P. C. Allen, D. W. Park, S. FitzCoy, D. A. Bautista, and E. P. Lillehoj. 2008. Immunopathology and cytokine responses in broiler chickens coinfected with Eimeria maxima and Clostridium perfringens with the use of an animal model of necrotic enteritis. Avian Dis.52:14-22.","journal-title":"Avian Dis."},{"key":"e_1_3_2_31_2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0739-7240(01)00128-X","volume":"22","year":"2002","unstructured":"Pfaffl, M. W., T. M. Georgieva, I. P. Georgiev, E. Ontsouka, M. Hageleit, and J. W. Blum. 2002. Real-time RT-PCR quantification of insulin-like growth factor (IGF)-1, IGF-1 receptor, IGF-2, IGF-2 receptor, insulin receptor, growth hormone receptor, IGF-binding proteins 1, 2 and 3 in the bovine species. Domest. Anim. Endocrinol.22:91-102.","journal-title":"Domest. Anim. Endocrinol."},{"key":"e_1_3_2_32_2","doi-asserted-by":"crossref","first-page":"9577","DOI":"10.1073\/pnas.0502272102","volume":"102","year":"2005","unstructured":"Roach, J. C., G. Glusman, L. Rowen, A. Kaur, M. K. Purcell, K. D. Smith, L. E. Hood, and A. Aderem. 2005. The evolution of vertebrate Toll-like receptors. Proc. Natl. Acad. Sci. USA102:9577-9582.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_2_33_2","first-page":"496","volume":"6","year":"2005","unstructured":"Rossignol, D. P., and M. Lynn. 2005. TLR4 antagonists for endotoxemia and beyond. Curr. Opin. Investig. Drugs6:496-502.","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"e_1_3_2_34_2","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/S0006-291X(03)01049-0","volume":"306","year":"2003","unstructured":"Sakaguchi, S., H. Negishi, M. Asagiri, C. Nakajima, T. Mizutani, A. Takaoka, K. Honda, and T. Taniguchi. 2003. Essential role of IRF-3 in lipopolysaccharide-induced interferon-beta gene expression and endotoxin shock. Biochem. Biophys. Res. Commun.306:860-866.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"e_1_3_2_35_2","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/1471-2164-10-260","volume":"10","year":"2009","unstructured":"Sarson, A. J., Y. Wang, Z. Kang, S. E. Dowd, Y. Lu, H. Yu, Y. Han, H. Zhou, and J. Gong. 2009. Gene expression profiling within the spleen of Clostridium perfringens-challenged broilers fed antibiotic-medicated and non-medicated diets. BMC Genomics10:260.","journal-title":"BMC Genomics"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01108-07"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.9.2.216"},{"key":"e_1_3_2_38_2","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1471-2164-9-62","volume":"9","year":"2008","unstructured":"Temperley, N. D., S. Berlin, I. R. Paton, D. K. Griffin, and D. W. Burt. 2008. Evolution of the chicken Toll-like receptor gene family: a story of gene gain and gene loss. BMC Genomics9:62.","journal-title":"BMC Genomics"},{"key":"e_1_3_2_39_2","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1600-0765.2006.00890.x","volume":"41","year":"2006","unstructured":"Tietze, K., A. Dalpke, S. Morath, R. Mutters, K. Heeg, and C. Nonnenmacher. 2006. Differences in innate immune responses upon stimulation with gram-positive and gram-negative bacteria. J. Periodontal Res.41:447-454.","journal-title":"J. Periodontal Res."},{"key":"e_1_3_2_40_2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0952-7915(01)00304-1","volume":"14","year":"2002","unstructured":"Underhill, D. M., and A. Ozinsky. 2002. Toll-like receptors: key mediators of microbe detection. Curr. Opin. Immunol.14:103-110.","journal-title":"Curr. Opin. Immunol."},{"key":"e_1_3_2_41_2","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1080\/03079450400013162","volume":"33","year":"2004","unstructured":"Van Immerseel, F., J. De Buck, F. Pasmans, G. Huyghebaert, F. Haesebrouck, and R. Ducatelle. 2004. Clostridium perfringens in poultry: an emerging threat for animal and public health. Avian Pathol.33:537-549.","journal-title":"Avian Pathol."},{"key":"e_1_3_2_42_2","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.tim.2008.09.005","volume":"17","year":"2009","unstructured":"Van Immerseel, F., J. I. Rood, R. J. Moore, and R. W. Titball. 2009. Rethinking our understanding of the pathogenesis of necrotic enteritis in chickens. Trends Microbiol.17:32-36.","journal-title":"Trends Microbiol."},{"key":"e_1_3_2_43_2","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.3382\/ps.2008-00343","volume":"88","year":"2009","unstructured":"Zhou, H., J. Gong, J. Brisbin, H. Yu, A. J. Sarson, W. Si, S. Sharif, and Y. Han. 2009. Transcriptional profiling analysis of host response to Clostridium perfringens infection in broilers. Poult. Sci.88:1023-1032.","journal-title":"Poult. Sci."}],"container-title":["Clinical and Vaccine Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00254-09","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00254-09","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T20:41:36Z","timestamp":1627591296000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/CVI.00254-09"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":42,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["10.1128\/CVI.00254-09"],"URL":"https:\/\/doi.org\/10.1128\/cvi.00254-09","relation":{},"ISSN":["1556-6811","1556-679X"],"issn-type":[{"value":"1556-6811","type":"print"},{"value":"1556-679X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11]]},"assertion":[{"value":"2009-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-09-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}