{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:30:51Z","timestamp":1790386251299,"version":"4.1.0"},"reference-count":44,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>Recent changes to the childhood immunization schedule in the United Kingdom have resulted in the inclusion of the 7-valent pneumococcal conjugate vaccine. However, the seroprevalence of pneumococcal antibodies in the population was unknown. To address this, we measured pneumococcal, age-specific immunoglobulin G (IgG) concentrations specific for nine serotypes by an assay run on the Bioplex platform, using 2,664 serum samples collected in England from 2000 to 2004. The lowest concentrations of IgG specific to all serotypes and the proportions of serotype-specific IgG concentrations of \u22650.35 \u03bcg\/ml were observed in children aged &lt;1 year. From 1 year on, there was a general increase in antibody levels with increasing age, and they remained high in adults. Maternal antibody was detected in young children aged &lt;36 days but waned rapidly. Comparison of the age-specific seroprevalence of serotype-specific IgG to the serotype-specific incidence of invasive pneumococcal disease demonstrated a general inverse relationship for all age groups except the elderly. These data provide a baseline for natural immunity to the pneumococcal serotypes analyzed prior to the introduction of pneumococcal conjugate vaccine in the United Kingdom.<\/jats:p>","DOI":"10.1128\/cvi.00264-07","type":"journal-article","created":{"date-parts":[[2007,9,20]],"date-time":"2007-09-20T00:48:52Z","timestamp":1190249332000},"page":"1442-1450","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":38,"title":["Age-Stratified Prevalences of Pneumococcal-Serotype-Specific Immunoglobulin G in England and Their Relationship to the Serotype-Specific Incidence of Invasive Pneumococcal Disease Prior to the Introduction of the Pneumococcal 7-Valent Conjugate Vaccine"],"prefix":"10.1128","volume":"14","author":[{"given":"Paul","family":"Balmer","sequence":"first","affiliation":[{"name":"Vaccine Evaluation Unit, Health Protection Agency North West, Manchester Royal Infirmary, Manchester, United Kingdom"},{"name":"Immunisation Division, Centre for Infections, Health Protection Agency, Colindale, London, United Kingdom"},{"name":"Respiratory and Systemic Infections Laboratory, Centre for Infections, Health Protection Agency, Colindale, London, United Kingdom"},{"name":"Statistics Unit, Centre for Infections, Health Protection Agency, Colindale, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ray","family":"Borrow","sequence":"additional","affiliation":[{"name":"Vaccine Evaluation Unit, Health Protection Agency North West, Manchester Royal Infirmary, Manchester, United Kingdom"},{"name":"Immunisation Division, Centre for Infections, Health Protection Agency, Colindale, London, United Kingdom"},{"name":"Respiratory and Systemic Infections Laboratory, Centre for Infections, Health Protection Agency, Colindale, London, United Kingdom"},{"name":"Statistics Unit, Centre for Infections, Health Protection Agency, Colindale, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Findlow","sequence":"additional","affiliation":[{"name":"Vaccine Evaluation Unit, Health Protection Agency North West, Manchester Royal Infirmary, Manchester, United Kingdom"},{"name":"Immunisation Division, Centre for Infections, Health Protection Agency, Colindale, London, United Kingdom"},{"name":"Respiratory and Systemic Infections Laboratory, Centre for Infections, Health Protection Agency, Colindale, London, United Kingdom"},{"name":"Statistics Unit, Centre for Infections, Health Protection Agency, Colindale, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalind","family":"Warrington","sequence":"additional","affiliation":[{"name":"Vaccine Evaluation Unit, Health Protection Agency North West, Manchester Royal Infirmary, Manchester, United Kingdom"},{"name":"Immunisation Division, Centre for Infections, Health Protection Agency, Colindale, London, United Kingdom"},{"name":"Respiratory and Systemic Infections Laboratory, Centre for Infections, Health Protection Agency, Colindale, London, United Kingdom"},{"name":"Statistics Unit, Centre for Infections, Health Protection Agency, Colindale, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Frankland","sequence":"additional","affiliation":[{"name":"Vaccine Evaluation Unit, Health Protection Agency North West, Manchester Royal Infirmary, Manchester, United Kingdom"},{"name":"Immunisation Division, Centre for Infections, Health Protection Agency, Colindale, London, United Kingdom"},{"name":"Respiratory and Systemic Infections Laboratory, Centre for Infections, Health Protection Agency, Colindale, London, United Kingdom"},{"name":"Statistics Unit, Centre for Infections, Health Protection Agency, Colindale, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Waight","sequence":"additional","affiliation":[{"name":"Vaccine Evaluation Unit, Health Protection Agency North West, Manchester Royal Infirmary, Manchester, United Kingdom"},{"name":"Immunisation Division, Centre for Infections, Health Protection Agency, Colindale, London, United Kingdom"},{"name":"Respiratory and Systemic Infections Laboratory, Centre for Infections, Health Protection Agency, Colindale, London, United Kingdom"},{"name":"Statistics Unit, Centre for Infections, Health Protection Agency, Colindale, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"George","sequence":"additional","affiliation":[{"name":"Vaccine Evaluation Unit, Health Protection Agency North West, Manchester Royal Infirmary, Manchester, United Kingdom"},{"name":"Immunisation Division, Centre for Infections, Health Protection Agency, Colindale, London, United Kingdom"},{"name":"Respiratory and Systemic Infections Laboratory, Centre for Infections, Health Protection Agency, Colindale, London, United Kingdom"},{"name":"Statistics Unit, Centre for Infections, Health Protection Agency, Colindale, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Andrews","sequence":"additional","affiliation":[{"name":"Vaccine Evaluation Unit, Health Protection Agency North West, Manchester Royal Infirmary, Manchester, United Kingdom"},{"name":"Immunisation Division, Centre for Infections, Health Protection Agency, Colindale, London, United Kingdom"},{"name":"Respiratory and Systemic Infections Laboratory, Centre for Infections, Health Protection Agency, Colindale, London, United Kingdom"},{"name":"Statistics Unit, Centre for Infections, Health Protection Agency, Colindale, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Miller","sequence":"additional","affiliation":[{"name":"Vaccine Evaluation Unit, Health Protection Agency North West, Manchester Royal Infirmary, Manchester, United Kingdom"},{"name":"Immunisation Division, Centre for Infections, Health Protection Agency, Colindale, London, United Kingdom"},{"name":"Respiratory and Systemic Infections Laboratory, Centre for Infections, Health Protection Agency, Colindale, London, United Kingdom"},{"name":"Statistics Unit, Centre for Infections, Health Protection Agency, Colindale, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/j.1365-2249.2003.02357.x","volume":"135","year":"2004","unstructured":"Baril, L., D. E. Briles, P. Crozier, J. D. King, S. K. Hollingshead, T. F. Murphy, and J. B. McCormick. 2004. Natural materno-fetal transfer of antibodies to PspA and to PsaA. Clin. Exp. Immunol.135:474-477.","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200003000-00003"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1086\/374624","volume":"187","year":"2003","unstructured":"Brueggemann, A. B., D. T. Griffiths, E. Meats, T. Peto, D. W. Crook, and B. G. Spratt. 2003. Clonal relationships between invasive and carriage Streptococcus pneumoniae and serotype- and clone-specific differences in invasive disease potential. J. Infect. Dis.187:1424-1432.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_5_2","unstructured":"Important changes to the childhood immunisation programme. 2006"},{"key":"e_1_3_2_6_2","first-page":"112","volume":"118","year":"1969","unstructured":"Cockburn, W. C. 1969. World aspects of the epidemiology of rubella. Am. J. Dis. Child.118:112-122.","journal-title":"Am. J. Dis. Child."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.25.3.960-963.1979"},{"key":"e_1_3_2_8_2","first-page":"CD000422","volume":"4","year":"2003","unstructured":"Dear, K., J. Holden, R. Andrews, and D. Tatham. 2003. Vaccines for preventing pneumococcal infection in adults. Cochrane Database Syst. Rev.4:CD000422.","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_3_2_9_2","first-page":"244","year":"2006","unstructured":"Devaster, J. M., I. Leroux-Roels, G. Leroux-Roels, P. Vandepapeliere, Y. Horsmans, I. Henckaerts, and J. Poolman. 2006. Inferior humoral response in elderly versus young adults to the 23-valent polysaccharide vaccine, p. 244. Abstr. 5th Int. Symp. Pneumococci Pneumococcal Dis., Alice Springs, Australia, 2 to 6 April 2006.","journal-title":"Inferior humoral response in elderly versus young adults to the 23-valent polysaccharide vaccine"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1093\/infdis\/137.3.328","volume":"137","year":"1978","unstructured":"Dienstag, J. L., W. Szmuness, C. E. Stevens, and R. H. Purcell. 1978. Hepatitis A virus infection: new insights from seroepidemiologic studies. J. Infect. Dis.137:328-340.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/infdis\/171.1.99","volume":"171","year":"1995","unstructured":"Englund, J. A., W. P. Glezen, C. Turner, J. Harvey, C. Thompson, and G. R. Siber. 1995. Transplacental antibody transfer following maternal immunization with polysaccharide and conjugate Haemophilus influenzae type b vaccines. J. Infect. Dis.171:99-105.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_12_2","first-page":"65","volume":"270","year":"1956","unstructured":"Fallon, R. J. 1956. Serological epidemiology of poliomyelitis; distribution of immunity to poliomyelitis virus. Lancet270:65-69.","journal-title":"Lancet"},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1086\/431524","volume":"192","year":"2005","unstructured":"Goldblatt, D., M. Hussain, N. Andrews, L. Ashton, C. Virta, A. Melegaro, R. Pebody, R. George, A. Soininen, J. Edmunds, N. Gay, H. Kayhty, and E. Miller. 2005. Antibody responses to nasopharyngeal carriage of Streptococcus pneumoniae in adults: a longitudinal household study. J. Infect. Dis.192:387-393.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000207483.60267.e7"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1084\/jem.129.6.1327","volume":"129","year":"1969","unstructured":"Goldschneider, I., E. C. Gotschlich, and M. S. Artenstein. 1969. Human immunity to the meningococcus: II. Development of natural immunity. J. Exp. Med.129:1327-1348.","journal-title":"J. Exp. Med."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.09.009"},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1080\/00365540310013315","volume":"35","year":"2003","unstructured":"Hedlund, J., M. Sorberg, B. Henriques Normark, and G. Kronvall. 2003. Capsular types and antibiotic susceptibility of invasive Streptococcus pneumoniae among children in Sweden. Scand. J. Infect. Dis.35:452-458.","journal-title":"Scand. J. Infect. Dis."},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1017\/S0950268805004012","volume":"133","year":"2005","unstructured":"Hussain, M., A. Melegaro, R. G. Pebody, R. George, W. J. Edmunds, R. Talukdar, S. A. Martin, A. Efstratiou, and E. Miller. 2005. A longitudinal household study of Streptococcus pneumoniae nasopharyngeal carriage in a UK setting. Epidemiol. Infect.133:891-898.","journal-title":"Epidemiol. Infect."},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1086\/422531","volume":"190","year":"2004","unstructured":"Jokinen, J. T., H. Ahman, T. M. Kilpi, P. H. Makela, and M. H. Kayhty. 2004. Concentration of antipneumococcal antibodies as a serological correlate of protection: an application to acute otitis media. J. Infect. Dis.190:545-550.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000151022.92222.be"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035060"},{"key":"e_1_3_2_22_2","first-page":"371","volume":"91","year":"1983","unstructured":"Lagerg\u00e5rd, T., and P. Branefors. 1983. Nature of cross-reactivity between Haemophilus influenzae types a and b and Streptococcus pneumoniae types 6A and 6B. Acta Pathol. Microbiol. Immunol. Scand. Sect. C91:371-376.","journal-title":"Acta Pathol. Microbiol. Immunol. Scand. Sect. C"},{"key":"e_1_3_2_23_2","first-page":"164","year":"2006","unstructured":"Lagos, R., A. Mu\u00f1oz, O. San Mart\u00edn, I. Heitmann, H. Loyola, and M. M. Levine. 2006. Secular variations in age incidence (Inc) and serotypes (St) causing invasive pneumococcal disease (IPD) in children 0 to 59 months of age (MoA) in the metropolitan region (MR), Chile, p. 164. Abstr. 5th Int. Symp. Pneumococci Pneumococcal Dis., Alice Springs, Australia, 2 to 6 April 2006.","journal-title":"Secular variations in age incidence (Inc) and serotypes (St) causing invasive pneumococcal disease (IPD) in children 0 to 59 months of age (MoA) in the metropolitan region (MR), Chile"},{"key":"e_1_3_2_24_2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jim.2004.11.006","volume":"296","year":"2005","unstructured":"Lal, G., P. Balmer, E. Stanford, S. Martin, R. Warrington, and R. Borrow. 2005. Development and validation of a nonaplex assay for the simultaneous quantitation of antibodies to nine Streptococcus pneumoniae serotypes. J. Immunol. Methods296:135-147.","journal-title":"J. Immunol. Methods"},{"key":"e_1_3_2_25_2","first-page":"598","volume":"308","year":"1994","unstructured":"Miller, E., M. Rush, P. Morgan-Capner, D. Hutchinson, and L. Hindle. 1994. Immunity to diphtheria in adults in England. BMJ308:598.","journal-title":"BMJ"},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1136\/bmj.297.6651.770","volume":"297","year":"1988","unstructured":"Morgan-Capner, P., J. Wright, C. L. Miller, and E. Miller. 1988. Surveillance of antibody to measles, mumps and rubella by age. BMJ297:770-772.","journal-title":"BMJ"},{"key":"e_1_3_2_27_2","first-page":"210","year":"2006","unstructured":"Moss, S. J., A. C. Fenton, R. Borrow, P. Balmer, J. Smith, and A. R. Gennery. 2006. Immunogenicity of a conjugate meningococcal group C (MCC) administered to term infants according to the current UK immunisation schedule at the same time as a seven valent conjugate pneumococcal vaccine (7VCPnc), p. 210. Abstr. 24th Meet. Eur. Soc. Paediatr. Infect. Dis., Basel, Switzerland, 3 to 5 May 2006.","journal-title":"Immunogenicity of a conjugate meningococcal group C (MCC) administered to term infants according to the current UK immunisation schedule at the same time as a seven valent conjugate pneumococcal vaccine (7VCPnc)"},{"key":"e_1_3_2_28_2","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1080\/inf.33.11.848.850","volume":"33","year":"2001","unstructured":"Normark, B. H., A. Ortqvist, M. Kalin, B. Olsson-Liljequist, J. Hedlund, S. B. Svenson, and G. K\u00e4llenius. 2001. Changes in serotype distribution may hamper efficacy of pneumococcal conjugate vaccines in children. Scand. J. Infect. Dis.33:848-850.","journal-title":"Scand. J. Infect. Dis."},{"key":"e_1_3_2_29_2","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1086\/518438","volume":"196","year":"2007","unstructured":"O'Brien, K. L., J. Moisi, L. H. Moulton, D. Madore, A. Elick, R. Reid, R. Weatherholtz, E. Millar, D. Hu, J. Hackell, R. Kohberger, G. Siber, and M. Santosham. 2007. Predictors of pneumococcal conjugate vaccine immunogenicity among infants and toddlers in an American Indian PnCRM7 efficacy trial. J. Infect. Dis.196:104-114.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14022-6"},{"key":"e_1_3_2_31_2","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1093\/ije\/29.2.362","volume":"29","year":"2000","unstructured":"Osborne, K., N. J. Gay, L. Hesketh, P. Morgan-Capner, and E. Miller. 2000. Ten years of serological surveillance in England and Wales: methods, results, implications and action. Int. J. Epidemiol.29:362-368.","journal-title":"Int. J. Epidemiol."},{"key":"e_1_3_2_32_2","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.3201\/eid1010.040335","volume":"10","year":"2004","unstructured":"Pollard, A. J., J. Ochnio, M. Ho, M. Callaghan, M. Bigham, and S. Dobsong. 2004. Disease susceptibility to ST11 complex meningococci bearing serogroup C or W135 polysaccharide capsules, North America. Emerg. Infect. Dis.10:1812-1815.","journal-title":"Emerg. Infect. Dis."},{"key":"e_1_3_2_33_2","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1542\/peds.101.4.604","volume":"101","year":"1998","unstructured":"Rennels, M. B., K. M. Edwards, H. L. Keyserling, K. S. Reisinger, D. A. Hogerman, D. V. Madore, I. Chang, P. R. Paradiso, F. J. Malinoski, and A. Kimura. 1998. Safety and immunogenicity of heptavalent pneumococcal vaccine conjugated to CRM197 in United States infants. Pediatrics101:604-611.","journal-title":"Pediatrics"},{"key":"e_1_3_2_34_2","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1086\/520200","volume":"29","year":"1999","unstructured":"Romero-Steiner, S., D. M. Musher, M. S. Cetron, L. B. Pais, J. E. Groover, A. E. Fiore, B. D. Plikaytis, and G. M. Carlone. 1999. Reduction in functional antibody activity against Streptococcus pneumoniae in vaccinated elderly individuals highly correlates with decreased IgG antibody avidity. Clin. Infect. Dis.29:281-288.","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_2_35_2","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/S0140-6736(95)91861-2","volume":"346","year":"1995","unstructured":"Shahid, N. S., M. C. Steinhoff, S. S. Hoque, T. Begum, C. Thompson, and G. R. Siber. 1995. Serum, breast milk and infant antibody after maternal immunisation with pneumococcal vaccine. Lancet346:1252-1257.","journal-title":"Lancet"},{"key":"e_1_3_2_36_2","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1097\/00006454-199909000-00004","volume":"18","year":"1999","unstructured":"Shinefield, H. R., S. Black, P. Ray, I. Chang, N. Lewis, B. Fireman, J. Hackell, P. R. Paradiso, G. Siber, R. Kohberger, D. V. Madore, F. J. Malinowski, A. Kimura, C. Le, I. Landaw, J. Aquilar, and J. Hansen. 1999. Safety and immunogenicity of heptavalent pneumococcal CRM197 conjugate vaccine in infants and toddlers. Pediatr. Infect. Dis. J.18:757-763.","journal-title":"Pediatr. Infect. Dis. J."},{"key":"e_1_3_2_37_2","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S0022-3476(05)80865-0","volume":"123","year":"1993","unstructured":"Shurin, P. A., J. M. Rehmus, C. E. Johnson, C. D. Marchant, S. A. Carlin, D. M. Super, G. F. Van Hare, P. K. Jones, D. M. Ambrosino, and G. Siber. 1993. Bacterial polysaccharide immune globulin for prophylaxis of acute otitis media in high-risk children. J. Pediatr.123:801-810.","journal-title":"J. Pediatr."},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.01.119"},{"key":"e_1_3_2_39_2","doi-asserted-by":"crossref","first-page":"S129","DOI":"10.1093\/infdis\/165-Supplement_1-S129","volume":"165","year":"1992","unstructured":"Siber, G. R., C. Thompson, G. R. Reid, J. Almeido-Hill, B. Zacher, M. Wolff, and M. Santosham. 1992. Evaluation of bacterial polysaccharide immune globulin for the treatment or prevention of Haemophilus influenzae type b and pneumococcal disease. J. Infect. Dis.165(Suppl. 1):S129-S133.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_40_2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1017\/S0950268800056648","volume":"111","year":"1993","unstructured":"Smith, T., D. Lehmann, J. Montgomery, M. Gratten, I. D. Riley, and M. P. Alpers. 1993. Acquisition and invasiveness of different serotypes of Streptococcus pneumoniae in young children. Epidemiol. Infect.111:27-39.","journal-title":"Epidemiol. Infect."},{"key":"e_1_3_2_41_2","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1086\/322794","volume":"184","year":"2001","unstructured":"Soininen, A., K. Pursiainen, T. Kilpi, and H. Kayhty. 2001. Natural development of antibodies to pneumococcal capsular polysaccharides depends on the serotype: association with pneumococcal carriage and acute otitis media in young children. J. Infect. Dis.184:569-576.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_42_2","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/S0264-410X(02)00630-8","volume":"21","year":"2003","unstructured":"Trotter, C., R. Borrow, N. Andrews, and E. Miller. 2003. Seroprevalence of meningococcal serogroup C bactericidal antibody in England and Wales in the pre-vaccination era. Vaccine21:1094-1098.","journal-title":"Vaccine"},{"key":"e_1_3_2_43_2","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/S0140-6736(03)13172-8","volume":"361","year":"2003","unstructured":"Trotter, C. L., J. McVernon, N. J. Andrews, M. Burrage, and M. E. Ramsay. 2003. Antibody to Haemophilus influenzae type b after routine and catch-up vaccination. Lancet361:1523-1524.","journal-title":"Lancet"},{"key":"e_1_3_2_44_2","unstructured":"Training manual for enzyme linked immunosorbent assay for the quantitation of Streptococcus pneumoniae serotype specific IgG (Pn PS ELISA). 2007"},{"key":"e_1_3_2_45_2","first-page":"64","volume":"927","year":"2005","unstructured":"World Health Organization. 2005. Recommendations for the production and control of pneumococcal conjugate vaccines. WHO Tech. Rep. Ser.927(Annex 2):64-98.","journal-title":"WHO Tech. Rep. Ser."}],"container-title":["Clinical and Vaccine Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00264-07","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00264-07","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T20:37:40Z","timestamp":1627591060000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/CVI.00264-07"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":44,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["10.1128\/CVI.00264-07"],"URL":"https:\/\/doi.org\/10.1128\/cvi.00264-07","relation":{},"ISSN":["1556-6811","1556-679X"],"issn-type":[{"value":"1556-6811","type":"print"},{"value":"1556-679X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11]]},"assertion":[{"value":"2007-06-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-09-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}