{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T08:23:36Z","timestamp":1749457416805},"reference-count":13,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Paracoccidioidomycosis is endemic in Latin America, and ca. 80% of all cases occur in Brazil. Little is known about antibody avidity or the evolution of such avidity in the posttherapeutic period for the different clinical presentations of the disease. In the present study, we evaluated 53 patients with paracoccidioidomycosis and calculated the avidity index. Medium- and high-avidity antibodies were found in 79.5% of patients with chronic presentation (\n            <jats:italic>n<\/jats:italic>\n            = 39). Among patients with the acute form (\n            <jats:italic>n<\/jats:italic>\n            = 14), 57.1% of the antibodies presented low avidity. In the posttherapeutic period, there was a significant increase in antibody avidity in patients presenting with the chronic multifocal form. In our preliminary study, which needs to be confirmed using a larger number of samples, the optimized method for studying antibody avidity detected differences among the clinical presentations of the mycosis and indicated the value of the avidity index as a marker of posttherapeutic evolution of patients with a multifocal chronic form of the disease.\n          <\/jats:p>","DOI":"10.1128\/cvi.00265-09","type":"journal-article","created":{"date-parts":[[2009,9,3]],"date-time":"2009-09-03T01:33:12Z","timestamp":1251941592000},"page":"1583-1586","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["Increased Immunoglobulin G Anti-\n            <i>Paracoccidioides brasiliensis<\/i>\n            Serum Antibody Avidity as a Predictor of Favorable Posttherapeutic Evolution in Paracoccidioidomycosis"],"prefix":"10.1128","volume":"16","author":[{"given":"Ma\u0301rcia","family":"Yoshida","sequence":"first","affiliation":[{"name":"Departamento de Mole\u0301stias Infecciosas e Parasita\u0301rias, Hospital das Cli\u0301nicas, Faculdade de Medicina, Universidade de Sa\u0303o Paulo e Laborato\u0301rio de Investigac\u0327a\u0303o Me\u0301dica-LIM 48, Hospital das Cli\u0301nicas, Faculdade de Medicina, Universidade de Sa\u0303o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Carmen","family":"Arroyo Sanchez","sequence":"additional","affiliation":[{"name":"Laborato\u0301rio de Soroepidemiologia e Imunobiologia, Instituto de Medicina Tropical de Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Aparecida","family":"Shikanai-Yasuda","sequence":"additional","affiliation":[{"name":"Departamento de Mole\u0301stias Infecciosas e Parasita\u0301rias, Hospital das Cli\u0301nicas, Faculdade de Medicina, Universidade de Sa\u0303o Paulo e Laborato\u0301rio de Investigac\u0327a\u0303o Me\u0301dica-LIM 48, Hospital das Cli\u0301nicas, Faculdade de Medicina, Universidade de Sa\u0303o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.4269\/ajtmh.1996.54.7","volume":"54","year":"1996","unstructured":"Benard, G., M. 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