{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:00:19Z","timestamp":1762866019527},"reference-count":32,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The development of an appropriate animal therapeutic model is essential to assess the potential efficacy of therapeutics for use in the event of a\n            <jats:named-content content-type=\"genus-species\">Bacillus anthracis<\/jats:named-content>\n            exposure. We conducted a natural history study that showed New Zealand White rabbits exhibited a significant increase in body temperature (SIBT), changes in hematologic parameters, and increases in C-reactive protein and succumbed to disease with an average time to death of approximately 73 h following aerosol challenge with\n            <jats:named-content content-type=\"genus-species\">B. anthracis<\/jats:named-content>\n            Ames spores. The SIBT was used as a trigger to treat with a fully human monoclonal antibody directed at protective antigen (PA). Ninety percent (9\/10) of the treated rabbits survived the lethal inhalational challenge of\n            <jats:named-content content-type=\"genus-species\">B. anthracis<\/jats:named-content>\n            . Further characterization investigated the protective window of opportunity for anti-PA antibody administration up to 12 h post-onset of SIBT. Eighty-three percent (5\/6) of the rabbits treated at SIBT and 100% (6\/6) of those treated at 6 h after SIBT survived challenge. Only 67% (4\/6) of the rabbits treated at 12 h after SIBT survived. The increase in body temperature corresponded with both bacteremia and antigenemia (PA in the blood), indicating that SIBT is a suitable trigger to initiate treatment in a therapeutic model of inhalational anthrax.\n          <\/jats:p>","DOI":"10.1128\/cvi.00292-12","type":"journal-article","created":{"date-parts":[[2012,7,26]],"date-time":"2012-07-26T04:38:15Z","timestamp":1343277495000},"page":"1517-1525","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":27,"title":["Characterization of a Therapeutic Model of Inhalational Anthrax Using an Increase in Body Temperature in New Zealand White Rabbits as a Trigger for Treatment"],"prefix":"10.1128","volume":"19","author":[{"given":"Jason E.","family":"Comer","sequence":"first","affiliation":[{"name":"Battelle, Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan D.","family":"Ray","sequence":"additional","affiliation":[{"name":"Battelle, Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa N.","family":"Henning","sequence":"additional","affiliation":[{"name":"Battelle, Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory V.","family":"Stark","sequence":"additional","affiliation":[{"name":"Battelle, Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy E.","family":"Barnewall","sequence":"additional","affiliation":[{"name":"Battelle, Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason M.","family":"Mott","sequence":"additional","affiliation":[{"name":"Battelle, Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel T.","family":"Meister","sequence":"additional","affiliation":[{"name":"Battelle, Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/S0014-5793(02)03609-8","article-title":"Anthrax toxin: a tripartite lethal combination","volume":"531","author":"Ascenzi P","year":"2002","unstructured":"AscenziP. 2002. Anthrax toxin: a tripartite lethal combination. FEBS Lett. 531:384\u2013388.","journal-title":"FEBS Lett."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00346-09"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909093411107"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ab.2012.02.040","article-title":"Ultra-fast pg\/ml anthrax toxin (protective antigen) detection assay based on microwave-accelerated metal-enhanced fluorescence","volume":"425","author":"Dragan AI","year":"2012","unstructured":"DraganAI AlbrechtMT PavlovicR Keane-MyersAM GeddesCD. 2012. Ultra-fast pg\/ml anthrax toxin (protective antigen) detection assay based on microwave-accelerated metal-enhanced fluorescence. Anal. Biochem. 425:54\u201361.","journal-title":"Anal. 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