{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:13:20Z","timestamp":1791029600721,"version":"4.1.0"},"reference-count":29,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Antigen-specific gamma interferon (IFN-\u03b3) has been demonstrated to participate in protection against\n            <jats:italic>Bordetella pertussis<\/jats:italic>\n            infection. Circulating mononuclear cells from\n            <jats:italic>B. pertussis<\/jats:italic>\n            -infected and from pertussis-vaccinated infants secrete high amounts of IFN-\u03b3 after in vitro stimulation by\n            <jats:italic>B. pertussis<\/jats:italic>\n            antigens, but with a large variation in the secreted IFN-\u03b3 levels between individuals. We show here that the inhibition of the specific IFN-\u03b3 response can be at least partially attributed to IL-10 secretion by monocytes. This IL-10 secretion was not associated with polymorphisms at positions \u22121082, \u2212819, and \u2212592 of the IL-10 gene promoter, suggesting that other genetic or environmental factors affect IL-10 expression and secretion.\n          <\/jats:p>","DOI":"10.1128\/cvi.00314-09","type":"journal-article","created":{"date-parts":[[2009,10,22]],"date-time":"2009-10-22T01:52:36Z","timestamp":1256176356000},"page":"1816-1821","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":28,"title":["Monocyte-Derived Interleukin-10 Depresses the\n            <i>Bordetella pertussis<\/i>\n            - Specific Gamma Interferon Response in Vaccinated Infants"],"prefix":"10.1128","volume":"16","author":[{"given":"V.","family":"Dirix","sequence":"first","affiliation":[{"name":"Laboratory of Vaccinology and Mucosal Immunity"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Verscheure","sequence":"additional","affiliation":[{"name":"Laboratory of Vaccinology and Mucosal Immunity"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Goetghebuer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Ho\u0302pital Saint-Pierre, Universite\u0301 Libre de Bruxelles, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hainaut","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Ho\u0302pital Saint-Pierre, Universite\u0301 Libre de Bruxelles, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. S.","family":"Debrie","sequence":"additional","affiliation":[{"name":"INSERM U629, F-59019 Lille, France"},{"name":"Institut Pasteur de Lille, F-59019 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Locht","sequence":"additional","affiliation":[{"name":"INSERM U629, F-59019 Lille, France"},{"name":"Institut Pasteur de Lille, F-59019 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Mascart","sequence":"additional","affiliation":[{"name":"Laboratory of Vaccinology and Mucosal Immunity"},{"name":"Immunobiology Clinic, Ho\u0302pital Erasme"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.10.6038-6043.2001"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.58.6.1518-1526.1990"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.6.2168-2174.1997"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1002\/hep.510300207","volume":"30","year":"1999","unstructured":"Edwards-Smith, C. J., J. R. Jonsson, D. M. Purdie, A. Bansal, C. Shorthouse, and E. E. Powell. 1999. Interleukin-10 promoter polymorphism predicts initial response of chronic hepatitis C to interferon alfa. Hepatology.30:526-530.","journal-title":"Hepatology."},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"9465","DOI":"10.1073\/pnas.95.16.9465","volume":"95","year":"1998","unstructured":"Eskalde, J., G. Gallgher, C. L. Verweij, V. Keijsers, R. G. J. Westendorp, and T. W. J. Huizinga. 1998. Interleukin 10 secretion in relation to human IL-10 locus haplotypes. Proc. Natl. Acad. Sci. USA95:9465-9470.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0022-3476(98)70395-6","volume":"132","year":"1998","unstructured":"Giuliano, M., P. Mastrantonio, A. Giammanco, A. Piscitelli, S. Salmaso, and S. G. Wassilak. 1998. Antibody responses and persistence in two years after immunization with two acellular vaccines and one whole-cell vaccine against pertussis. J. Pediatr.132:983-988.","journal-title":"J. Pediatr."},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1056\/NEJM199602083340602","volume":"334","year":"1996","unstructured":"Gustafsson, L., H. O. Hallander, P. Olin, E. Reizenstein, and J. Storsaeter. 1996. A controlled trial of a two-component acellular, a five-component acellular and a whole-cell pertussis vaccine. N. Engl. J. Med.334:349-355.","journal-title":"N. Engl. J. Med."},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1046\/j.1365-3083.2000.00741.x","volume":"52","year":"2000","unstructured":"Hessle, C., L. A. Hanson, and A. E. Wold. 2000. Interleukin-10 produced by the innate immune system masks in vitro evidence of acquired T-cell immunity to E.coli. Scand. J. Immunol.52:13-20.","journal-title":"Scand. J. Immunol."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.12.6688-6696.2002"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/cdli.3.5.493-499.1996"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1084\/jem.191.11.1841","volume":"191","year":"2000","unstructured":"Leef, M., K. L. Elkins, J. Barbic, and R. D. Shahin. 2000. Protective immunity to Bordetella pertussis requires both B cells and CD4+ T cells for key functions other than specific antibody production. J. Exp. Med.191:1841-1852.","journal-title":"J. Exp. Med."},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1084\/jem.186.11.1843","volume":"186","year":"1997","unstructured":"Mahon, B. P., B. J. Sheahan, F. Griffin, G. Murphy, and K. H. Mills. 1997. Atypical disease after Bordetella pertussis respiratory infection of mice with targeted disruptions of interferon-\u03b3 receptor or immunoglobulin \u03bc chain genes. J. Exp. Med.186:1843-1851.","journal-title":"J. Exp. Med."},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1086\/597304","volume":"199","year":"2009","unstructured":"Mansoor, N., T. J. Scriba, M. de Kock, M. Tameris, B. Abel, A. Keyser, F. Little, A. Soares, S. Gelderbloem, S. Mlenjeni, L. Denation, A. Hawkridge, W. H. Boom, G. Kaplan, G. D. Hussey, and W. A. Hanekom. 2009. HIV-1 infection in infants severely impairs the immune response induced by Bacille Calmette-Gu\u00e9rin vaccine. J. Infect. Dis.199:982-990.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/j.1365-3083.2005.01675.x","volume":"62","year":"2005","unstructured":"M\u00e1rka, M., B. Bessenyei, M. Zeher, and I. Semsei. 2005. IL-10 promoter \u22121082 polymorphism is associated with elevated IL-10 levels in control subjects but does not explain elevated plasma IL-10 observed in Sj\u00f6gren's syndrome in a Hungarian cohort. Scan. J. Immunol.62:474-480.","journal-title":"Scan. J. Immunol."},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.4049\/jimmunol.170.3.1504","volume":"170","year":"2003","unstructured":"Mascart, F., V. Verscheure, A. Malfroot, M. Hainaut, D. Pi\u00e9rard, S. Temerman, A. Peltier, A.-S. Debrie, J. Levy, G. Del Giudice, and C. Locht. 2003. Bordetella pertussis infection in 2-month-old infants promotes type 1 T cell responses. J. Immunol.170:1504-1509.","journal-title":"J. Immunol."},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.vaccine.2006.06.046","volume":"25","year":"2007","unstructured":"Mascart, F., M. Hainaut, A. Peltier, V. Verscheure, J. Levy, and C. Locht. 2007. Modulation of the infant immune responses by the first pertussis vaccine administrations. Vaccine25:391-398.","journal-title":"Vaccine"},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/1521-4141(200002)30:2<415::AID-IMMU415>3.0.CO;2-X","volume":"30","year":"2000","unstructured":"McGuirk, P., and K. H. Mills. 2000. Direct anti-inflammatory effect of a bacterial virulence factor: IL-10-dependent suppression of IL-12 production by filamentous hemagglutinin from Bordetella pertussis. Eur. J. Immunol.30:415-422.","journal-title":"Eur. J. Immunol."},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.2.399-410.1993"},{"key":"e_1_3_2_20_2","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S1286-4579(01)01421-6","volume":"3","year":"2001","unstructured":"Mills, K. H. 2001. Immunity to Bordetella pertussis. Microbes Infect.3:655-677.","journal-title":"Microbes Infect."},{"key":"e_1_3_2_21_2","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev.immunol.19.1.683","volume":"19","year":"2001","unstructured":"Moore, K. W., R. de Waal Malefyt, L. C. Coffman, and A. O'Garra. 2001. Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol.19:683-765.","journal-title":"Annu. Rev. Immunol."},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.3.1568-1579.2004"},{"key":"e_1_3_2_23_2","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1086\/593682","volume":"175","year":"1997","unstructured":"Ryan, M., G. Murphy, L. Gothefors, L. Nilsson, J. Storsaeter, and K. H. Mills. 1997. Bordetella pertussis respiratory infection in children is associated with preferential activation of type 1 T helper cells. J. Infect. Dis.175:1246-1250.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_24_2","doi-asserted-by":"crossref","first-page":"S441","DOI":"10.1016\/j.jaci.2005.07.001","volume":"117","year":"2006","unstructured":"Steinke, J. W., and L. Borish. 2006. 3. Cytokines and chemokines. J. Allergy Clin. Immunol.117:S441-S445.","journal-title":"J. Allergy Clin. Immunol."},{"key":"e_1_3_2_25_2","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1097\/01.TP.0000055216.19866.9A","volume":"75","year":"2003","unstructured":"Suarez, A., P. Castro, R. Alonso, L. Mozo, and C. Guttierrez. 2003. Interindividual variations in constitutive interleukin-10 messenger RNA and protein levels and their association with genetic polymorphisms. Transplantation.75:711-717.","journal-title":"Transplantation."},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2370.1997.tb00001.x","volume":"24","year":"1997","unstructured":"Turner, D. M., D. M. Williams, D. Sankaran, M. Lazarus, P. J. Sinnott, and I. V. Hutchinson. 1997. An investigation of polymorphism in the interleukin-10 gene. Eur. J. Immunogenet.24:1-8.","journal-title":"Eur. J. Immunogenet."},{"key":"e_1_3_2_27_2","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0140-6736(96)06413-6","volume":"349","year":"1997","unstructured":"Westendorp, R. G. J., J. A. M. Langermans, T. W. J. Huizinga, A. H. Elouali, C. L. Verweij, D. I. Boomsma, and J. P. Vandenbrouke. 1997. Genetic influence on cytokine production and fatal meningococcal disease. Lancet349:170-173.","journal-title":"Lancet"},{"key":"e_1_3_2_28_2","unstructured":"Immunization vaccines and biologicals: pertussis 2005"},{"key":"e_1_3_2_29_2","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jaci.2007.08.031","volume":"121","year":"2008","unstructured":"Yamazaki, K., J. A. Murray, and H. Kita. 2008. Innate immunomodulatory effects of cereal grains through induction of IL-10. J. Allergy Clin. Immunol.121:172-178.","journal-title":"J. Allergy Clin. Immunol."},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.10.4078-4084.1996"}],"container-title":["Clinical and Vaccine Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00314-09","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00314-09","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T20:41:28Z","timestamp":1627591288000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/CVI.00314-09"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["10.1128\/CVI.00314-09"],"URL":"https:\/\/doi.org\/10.1128\/cvi.00314-09","relation":{},"ISSN":["1556-6811","1556-679X"],"issn-type":[{"value":"1556-6811","type":"print"},{"value":"1556-679X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12]]},"assertion":[{"value":"2009-07-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-10-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}