{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T07:47:51Z","timestamp":1764402471357},"reference-count":19,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The immunogenicities of conjugate pneumococcal vaccines have been demonstrated when they are administered at 2, 3, and 4 months of age. There is a paucity of data on the immunogenicity of this vaccine when it is administered concurrently with other vaccines in the primary immunization schedule of the United Kingdom. We immunized 55 term infants at 2, 3, and 4 months of age with the seven-valent pneumococcal conjugate vaccine (PCV7), the meningococcal group C conjugate (MCC) vaccine, and the diphtheria, tetanus, five-component acellular pertussis, inactivated polio, and\n            <jats:italic>Haemophilus influenzae<\/jats:italic>\n            type b (DTaP\n            <jats:sub>5<\/jats:sub>\n            \/IPV\/Hib-TT) vaccine. The immune responses to the\n            <jats:italic>H. influenzae<\/jats:italic>\n            type b (Hib), MCC, and tetanus vaccines were measured at 2, 5, and 12 months of age; and the immune responses to PCV7 were measured at 2 and 5 months and then either at 12 months or following a 4th dose of PCV7. There were increases in the geometric mean concentrations (GMCs) of all antigens postimmunization. Greater than or equal to 90% of the infants achieved putatively protective levels postimmunization for all vaccine antigens except pneumococcal serotype 6B and Hib. The GMCs of the PCV7 serotypes increased following a 4th dose, although one infant had not reached putative levels of protection against serotype 6B. In conclusion, when infants were vaccinated according to the schedule described above, they had lower postprimary immunization responses to Hib, meningococcus group C capsular polysaccharide, and pneumococcal serotype 6B than the responses demonstrated by use of the other schedules. Despite this finding, there was a good response following a 4th dose of PCV7.\n          <\/jats:p>","DOI":"10.1128\/cvi.00315-09","type":"journal-article","created":{"date-parts":[[2009,12,31]],"date-time":"2009-12-31T02:44:03Z","timestamp":1262227443000},"page":"311-316","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Immunogenicity of a Heptavalent Conjugate Pneumococcal Vaccine Administered Concurrently with a Combination Diphtheria, Tetanus, Five-Component Acellular Pertussis, Inactivated Polio, and\n            <i>Haemophilus influenzae<\/i>\n            Type b Vaccine and a Meningococcal Group C Conjugate Vaccine at 2, 3, and 4 Months of Age"],"prefix":"10.1128","volume":"17","author":[{"given":"S. J.","family":"Moss","sequence":"first","affiliation":[{"name":"Newcastle Neonatal Services, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom"},{"name":"Clinical Medical Sciences, Newcastle University, Newcastle, United Kingdom"},{"name":"Vaccine Evaluation Unit, Health Protection Agency North West, Clinical Sciences Building 2, Manchester Royal Infirmary, Manchester, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. C.","family":"Fenton","sequence":"additional","affiliation":[{"name":"Newcastle Neonatal Services, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom"},{"name":"Clinical Medical Sciences, Newcastle University, Newcastle, United Kingdom"},{"name":"Vaccine Evaluation Unit, Health Protection Agency North West, Clinical Sciences Building 2, Manchester Royal Infirmary, Manchester, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Toomey","sequence":"additional","affiliation":[{"name":"Newcastle Neonatal Services, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom"},{"name":"Clinical Medical Sciences, Newcastle University, Newcastle, United Kingdom"},{"name":"Vaccine Evaluation Unit, Health Protection Agency North West, Clinical Sciences Building 2, Manchester Royal Infirmary, Manchester, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Grainger","sequence":"additional","affiliation":[{"name":"Newcastle Neonatal Services, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom"},{"name":"Clinical Medical Sciences, Newcastle University, Newcastle, United Kingdom"},{"name":"Vaccine Evaluation Unit, Health Protection Agency North West, Clinical Sciences Building 2, Manchester Royal Infirmary, Manchester, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Borrow","sequence":"additional","affiliation":[{"name":"Newcastle Neonatal Services, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom"},{"name":"Clinical Medical Sciences, Newcastle University, Newcastle, United Kingdom"},{"name":"Vaccine Evaluation Unit, Health Protection Agency North West, Clinical Sciences Building 2, Manchester Royal Infirmary, Manchester, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Balmer","sequence":"additional","affiliation":[{"name":"Newcastle Neonatal Services, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom"},{"name":"Clinical Medical Sciences, Newcastle University, Newcastle, United Kingdom"},{"name":"Vaccine Evaluation Unit, Health Protection Agency North West, Clinical Sciences Building 2, Manchester Royal Infirmary, Manchester, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Smith","sequence":"additional","affiliation":[{"name":"Newcastle Neonatal Services, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom"},{"name":"Clinical Medical Sciences, Newcastle University, Newcastle, United Kingdom"},{"name":"Vaccine Evaluation Unit, Health Protection Agency North West, Clinical Sciences Building 2, Manchester Royal Infirmary, Manchester, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. R.","family":"Gennery","sequence":"additional","affiliation":[{"name":"Newcastle Neonatal Services, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom"},{"name":"Clinical Medical Sciences, Newcastle University, Newcastle, United Kingdom"},{"name":"Vaccine Evaluation Unit, Health Protection Agency North West, Clinical Sciences Building 2, Manchester Royal Infirmary, Manchester, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"780","volume":"10","year":"2003","unstructured":"Andrews, N., R. Borrow, and E. Miller. 2003. Validation of serological correlate of protection for meningococcal C conjugate vaccine by using efficacy estimates from postlicensure surveillance in England. Clin. Diagn. Lab. Immunol.10:780-786.","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"e717","DOI":"10.1542\/peds.2005-0348","volume":"117","year":"2006","unstructured":"Berrington, J. E., A. J. Cant, J. N. Matthews, M. O'Keeffe, G. P. Spickett, and A. C. Fenton. 2006. Haemophilus influenzae type b immunization in infants in the United Kingdom: effects of diphtheria\/tetanus\/acellular pertussis\/Hib combination vaccine, significant prematurity, and a fourth dose. Pediatrics117:e717-e724.","journal-title":"Pediatrics"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200003000-00003"},{"key":"e_1_3_2_5_2","first-page":"289","year":"2000","unstructured":"Borrow, R., and E. B. Kaczmarksi. 2000. Meningococcal serology, p. 289-304. In A. J. Pollard and M. C. J. Maiden (ed.), Methods in molecular medicine. Human Press, Totowa, NJ.","journal-title":"Methods in molecular medicine"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1001\/jama.293.14.1751","volume":"293","year":"2005","unstructured":"Buttery, J. P., A. Riddell, J. McVernon, T. Chantler, L. Lane, J. Bowen-Morris, L. Diggle, R. Morris, A. Harnden, S. Lockhart, A. J. Pollard, K. Cartwright, and E. R. Moxon. 2005. Immunogenicity and safety of a combination pneumococcal-meningococcal vaccine in infants: a randomized controlled trial. JAMA293:1751-1758.","journal-title":"JAMA"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.30.1.154-159.1992"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1097\/00006454-200009000-00009","volume":"19","year":"2000","unstructured":"Choo, S., L. Seymour, R. Morris, S. Quataert, S. Lockhart, K. Cartwright, and A. Finn. 2000. Immunogenicity and reactogenicity of a pneumococcal conjugate vaccine administered combined with a Haemophilus influenzae type B conjugate vaccine in United Kingdom infants. Pediatr. Infect. Dis. J.19:854-862.","journal-title":"Pediatr. Infect. Dis. J."},{"key":"e_1_3_2_9_2","unstructured":"CMO. 2002 posting date. Pneumococcal vaccine for at-risk under 2 year olds. http:\/\/www.dh.gov.uk\/en\/publicationsandstatistics\/Lettersandcirculars\/Professionalletters\/chiefpharmaceuticalofficerletters\/DH_4004729\n."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000207483.60267.e7"},{"key":"e_1_3_2_11_2","unstructured":"Health Protection Agency. 2007 posting date. Pneumococcal serotype distribution for samples referred for serotyping epidemiological years (June). Health Protection Agency Manchester United Kingdom. 2000\/1-2005\/6 www.hpa.org.uk\/infections\n."},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1136\/adc.2005.076109","volume":"92","year":"2007","unstructured":"Kitchin, N. R., J. Southern, R. Morris, F. Hemme, S. Thomas, M. W. Watson, K. Cartwright, and E. Miller. 2007. Evaluation of a diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b vaccine given concurrently with meningococcal group C conjugate vaccine at 2, 3 and 4 months of age. Arch. Dis. Child.92:11-16.","journal-title":"Arch. Dis. Child."},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1586\/14760584.5.4.553","volume":"5","year":"2006","unstructured":"Lockhart, S. P., J. G. Hackell, and B. Fritzell. 2006. Pneumococcal conjugate vaccines: emerging clinical information and its implications. Expert Rev. Vaccines5:553-564.","journal-title":"Expert Rev. 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The safety and immunogenicity of an heptavalent pneumococcal polysaccharide conjugate vaccine (Prevenar) administered in association with a whole-cell pertussis-based pediatric combination vaccine (DTP-IPV\/PRP-T) to French infants with a two-, three-, and four-month schedule. Arch. Pediatr.10:1048-1055. (In French.)","journal-title":"Arch. Pediatr."},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.vaccine.2006.07.036","volume":"25","year":"2007","unstructured":"Ruggeberg, J. U., C. Collins, P. Clarke, N. Johnson, R. Sinha, N. Everest, J. Chang, E. Stanford, P. Balmer, R. Borrow, S. Martin, M. J. Robinson, E. R. Moxon, A. J. Pollard, and P. T. Heath. 2007. Immunogenicity and induction of immunological memory of the heptavalent pneumococcal conjugate vaccine in preterm UK infants. 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Ser."}],"container-title":["Clinical and Vaccine Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00315-09","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00315-09","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T20:42:52Z","timestamp":1627591372000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/CVI.00315-09"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["10.1128\/CVI.00315-09"],"URL":"https:\/\/doi.org\/10.1128\/cvi.00315-09","relation":{},"ISSN":["1556-6811","1556-679X"],"issn-type":[{"value":"1556-6811","type":"print"},{"value":"1556-679X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3]]},"assertion":[{"value":"2009-07-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-12-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}