{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T09:21:42Z","timestamp":1771665702608,"version":"3.50.1"},"reference-count":40,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>N<\/jats:italic>-Acetylglucosamine (GlcNAc) is the major immunoepitope of group A streptococcal cell wall carbohydrates. Antistreptococcal antibodies cross-reactive with anti-GlcNAc and laminin are present in sera of patients with rheumatic fever. The cross-reactivity of these antibodies with human heart valvular endothelium and the underlying basement membrane has been suggested to be a possible cause of immune-mediated valve lesion. Mannose-binding lectin (MBL) encoded by the<jats:italic>MBL2<\/jats:italic>gene, a soluble pathogen recognition receptor, has high affinity for GlcNAc. We postulated that mutations in exon 1 of the<jats:italic>MBL<\/jats:italic>2 gene associated with a deficient serum level of MBL may contribute to chronic severe aortic regurgitation (AR) of rheumatic etiology. We studied 90 patients with severe chronic AR of rheumatic etiology and 281 healthy controls (HC) for the variants of the<jats:italic>MBL2<\/jats:italic>gene at codons 52, 54, and 57 by using a PCR-restriction fragment length polymorphism-based method. We observed a significant difference in the prevalence of defective<jats:italic>MBL2<\/jats:italic>alleles between patients with chronic severe AR and HC. Sixteen percent of patients with chronic severe AR were homozygotes or compound heterozygotes for defective MBL alleles in contrast to 5% for HC (<jats:italic>P<\/jats:italic>= 0.0022; odds ratio, 3.5 [95% confidence interval, 1.6 to 7.7]). No association was detected with the variant of the<jats:italic>MASP2<\/jats:italic>gene. Our study suggests that MBL deficiency may contribute to the development of chronic severe AR of rheumatic etiology.<\/jats:p>","DOI":"10.1128\/cvi.00324-07","type":"journal-article","created":{"date-parts":[[2008,4,10]],"date-time":"2008-04-10T01:41:50Z","timestamp":1207791710000},"page":"932-936","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":51,"title":["Association of Mannose-Binding Lectin Gene Polymorphism but Not of Mannose-Binding Serine Protease 2 with Chronic Severe Aortic Regurgitation of Rheumatic Etiology"],"prefix":"10.1128","volume":"15","author":[{"given":"Rajendranath","family":"Ramasawmy","sequence":"first","affiliation":[{"name":"Heart Institute (InCor), University of Sao Paulo School of Medicine, Sao Paulo, Brazil"},{"name":"Institute for Investigation in Immunology, Millennium Institutes, Sao Paulo, Brazil"},{"name":"Clinical Immunology and Allergy Department, University of Sao Paulo School of Medicine, Sao Paulo, Brazil"},{"name":"Department of Clinical Pathology, Clinical Hospital, Federal University of Parana\u0301, Curitiba, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilherme S.","family":"Spina","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor), University of Sao Paulo School of Medicine, Sao Paulo, Brazil"},{"name":"Institute for Investigation in Immunology, Millennium Institutes, Sao Paulo, Brazil"},{"name":"Clinical Immunology and Allergy Department, University of Sao Paulo School of Medicine, Sao Paulo, Brazil"},{"name":"Department of Clinical Pathology, Clinical Hospital, Federal University of Parana\u0301, Curitiba, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kellen C.","family":"Fae","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor), University of Sao Paulo School of Medicine, Sao Paulo, Brazil"},{"name":"Institute for Investigation in Immunology, Millennium Institutes, Sao Paulo, Brazil"},{"name":"Clinical Immunology and Allergy Department, University of Sao Paulo School of Medicine, Sao Paulo, Brazil"},{"name":"Department of Clinical Pathology, Clinical Hospital, Federal University of Parana\u0301, Curitiba, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre C.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor), University of Sao Paulo School of Medicine, Sao Paulo, Brazil"},{"name":"Institute for Investigation in Immunology, Millennium Institutes, Sao Paulo, Brazil"},{"name":"Clinical Immunology and Allergy Department, University of Sao Paulo School of Medicine, Sao Paulo, Brazil"},{"name":"Department of Clinical Pathology, Clinical Hospital, Federal University of Parana\u0301, Curitiba, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"Nisihara","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor), University of Sao Paulo School of Medicine, Sao Paulo, Brazil"},{"name":"Institute for Investigation in Immunology, Millennium Institutes, Sao Paulo, Brazil"},{"name":"Clinical Immunology and Allergy Department, University of Sao Paulo School of Medicine, Sao Paulo, Brazil"},{"name":"Department of Clinical Pathology, Clinical Hospital, Federal University of Parana\u0301, Curitiba, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iara Jose","family":"Messias Reason","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor), University of Sao Paulo School of Medicine, Sao Paulo, Brazil"},{"name":"Institute for Investigation in Immunology, Millennium Institutes, Sao Paulo, Brazil"},{"name":"Clinical Immunology and Allergy Department, University of Sao Paulo School of Medicine, Sao Paulo, Brazil"},{"name":"Department of Clinical Pathology, Clinical Hospital, Federal University of Parana\u0301, Curitiba, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Grinberg","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor), University of Sao Paulo School of Medicine, Sao Paulo, Brazil"},{"name":"Institute for Investigation in Immunology, Millennium Institutes, Sao Paulo, Brazil"},{"name":"Clinical Immunology and Allergy Department, University of Sao Paulo School of Medicine, Sao Paulo, Brazil"},{"name":"Department of Clinical Pathology, Clinical Hospital, Federal University of Parana\u0301, Curitiba, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavio","family":"Tarasoutchi","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor), University of Sao Paulo School of Medicine, Sao Paulo, Brazil"},{"name":"Institute for Investigation in Immunology, Millennium Institutes, Sao Paulo, Brazil"},{"name":"Clinical Immunology and Allergy Department, University of Sao Paulo School of Medicine, Sao Paulo, Brazil"},{"name":"Department of Clinical Pathology, Clinical Hospital, Federal University of Parana\u0301, Curitiba, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Kalil","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor), University of Sao Paulo School of Medicine, Sao Paulo, Brazil"},{"name":"Institute for Investigation in Immunology, Millennium Institutes, Sao Paulo, Brazil"},{"name":"Clinical Immunology and Allergy Department, University of Sao Paulo School of Medicine, Sao Paulo, Brazil"},{"name":"Department of Clinical Pathology, Clinical Hospital, Federal University of Parana\u0301, Curitiba, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiza","family":"Guilherme","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor), University of Sao Paulo School of Medicine, Sao Paulo, Brazil"},{"name":"Institute for Investigation in Immunology, Millennium Institutes, Sao Paulo, Brazil"},{"name":"Clinical Immunology and Allergy Department, University of Sao Paulo School of Medicine, Sao Paulo, Brazil"},{"name":"Department of Clinical Pathology, Clinical Hospital, Federal University of Parana\u0301, Curitiba, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"5422","DOI":"10.4049\/jimmunol.159.11.5422","volume":"159","year":"1997","unstructured":"Antone, S. M., E. E. Adderson, N. M. Mertens, and M. W. Cunningham. 1997. Molecular analysis of V gene sequences encoding cytotoxic anti-streptococcal\/anti-myosin monoclonal antibody 36.2.2 that recognizes the heart cell surface protein laminin. J. Immunol.159:5422-5430.","journal-title":"J. Immunol."},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1161\/01.CIR.50.1.144","volume":"50","year":"1974","unstructured":"Ayoub, E. M., A. Taranta, and T. D. Bartley. 1974. Effect of valvular surgery on antibody to the group A streptococcal carbohydrate. Circulation50:144-150.","journal-title":"Circulation"},{"key":"e_1_3_2_4_2","first-page":"1799","year":"2000","unstructured":"Bisno, A. L. 2000. Nonsuppurative poststreptococcal sequelae: rheumatic fever and glomerulonephritis, p. 1799-1810. In G. L. Mandell, J. E. Bennett, and R. Dolin (ed.), Principles and practice of infectious diseases. Churchill Livingstone, New York, NY.","journal-title":"Principles and practice of infectious diseases."},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S1473-3099(03)00576-0","volume":"3","year":"2003","unstructured":"Bisno, A. L., M. O. Brito, and C. M. Collins. 2003. Molecular basis of group A streptococcal virulence. Lancet Infect. Dis.3:191-200.","journal-title":"Lancet Infect. Dis."},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.4049\/jimmunol.141.8.2760","volume":"141","year":"1988","unstructured":"Cunningham, M. W., J. M. McCormack, L. R. Talaber, J. B. Harley, E. M. Ayoub, R. S. Muneer, L. T. Chun, and D. V. Reddy. 1988. Human monoclonal antibodies reactive with antigens of the group A Streptococcus and human heart. J. Immunol.141:2760-2766.","journal-title":"J. Immunol."},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.4049\/jimmunol.136.1.293","volume":"136","year":"1986","unstructured":"Cunningham, M. W., N. K. Hall, K. K. Krisher, and A. M. Spanier. 1986. A study of anti-group A streptococcal monoclonal antibodies cross-reactive with myosin. J. Immunol.136:293-298.","journal-title":"J. Immunol."},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1084\/jem.161.1.113","volume":"161","year":"1985","unstructured":"Dale, J. B., and E. H. Beachey. 1985. Multiple, heart-cross-reactive epitopes of streptococcal M proteins. J. Exp. Med.161:113-122.","journal-title":"J. Exp. Med."},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1084\/jem.128.5.1081","volume":"128","year":"1968","unstructured":"Dudding, B. A., and E. M. Ayoub. 1968. Persistence of streptococcal group A antibody in patients with rheumatic valvular disease. J. Exp. Med.128:1081-1098.","journal-title":"J. Exp. Med."},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1086\/379324","volume":"37","year":"2003","unstructured":"Eisen, D. P., and R. M. Minchinton. 2003. Impact of mannose-binding lectin on susceptibility to infectious diseases. Clin. Infect. Dis.37:1496-1505.","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"5662","DOI":"10.4049\/jimmunol.176.9.5662","volume":"176","year":"2006","unstructured":"Fae, K. C., D. D. da Silva, S. E. Oshiro, A. C. Tanaka, P. M. Pomerantzeff, C. Douay, D. Charron, A. Toubert, M. W. Cunningham, J. Kalil, and L. Guilherme. 2006. Mimicry in recognition of cardiac myosin peptides by heart-intralesional T cell clones from rheumatic heart disease. J. Immunol.176:5662-5670.","journal-title":"J. Immunol."},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.4049\/jimmunol.142.7.2475","volume":"142","year":"1989","unstructured":"Fenderson, P. G., V. A. Fischetti, and M. W. Cunningham. 1989. Tropomyosin shares immunologic epitopes with group A streptococcal M proteins. J. Immunol.142:2475-2481.","journal-title":"J. Immunol."},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/rheumatology\/kel199","volume":"46","year":"2007","unstructured":"Font, J., M. Ramos-Casals, P. Brito-Zeron, N. Nardi, A. Ibanez, B. Suarez, S. Jimenez, D. Tassies, A. Garcia-Criado, E. Ros, J. Sentis, J. C. Reverter, and F. Lozano. 2007. Association of mannose-binding lectin gene polymorphisms with antiphospholipid syndrome, cardiovascular disease and chronic damage in patients with systemic lupus erythematosus. Rheumatology (Oxford)46:76-80.","journal-title":"Rheumatology (Oxford)"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1189\/jlb.1105683","volume":"80","year":"2006","unstructured":"Fraser, D. A., S. S. Bohlson, N. Jasinskiene, N. Rawal, G. Palmarini, S. Ruiz, R. Rochford, and A. J. Tenner. 2006. C1q and MBL, components of the innate immune system, influence monocyte cytokine expression. J. Leukoc. Biol.80:107-116.","journal-title":"J. Leukoc. Biol."},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1172\/JCI7132","volume":"106","year":"2000","unstructured":"Galvin, J. E., M. E. Hemric, K. Ward, and M. W. Cunningham. 2000. Cytotoxic mAb from rheumatic carditis recognizes heart valves and laminin. J. Clin. Investig.106:217-224.","journal-title":"J. Clin. Investig."},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/sj.gene.6364283","volume":"7","year":"2006","unstructured":"Garred, P., F. Larsen, J. Seyfarth, R. Fujita, and H. O. Madsen. 2006. Mannose-binding lectin and its genetic variants. Genes Immun.7:85-94.","journal-title":"Genes Immun."},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S0140-6736(96)08440-1","volume":"349","year":"1997","unstructured":"Garred, P., H. O. Madsen, U. Balslev, B. Hofmann, C. Pedersen, J. Gerstoft, and A. Svejgaard. 1997. Susceptibility to HIV infection and progression of AIDS in relation to variant alleles of mannose-binding lectin. Lancet349:236-240.","journal-title":"Lancet"},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/213044a0","volume":"213","year":"1967","unstructured":"Goldstein, I., B. Halpern, and L. Robert. 1967. Immunological relationship between streptococcus A polysaccharide and the structural glycoprotein of heart valve. Nature213:44-47.","journal-title":"Nature"},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/1529-0131(200003)43:3<515::AID-ANR6>3.0.CO;2-T","volume":"43","year":"2000","unstructured":"Graudal, N. A., H. O. Madsen, U. Tarp, A. Svejgaard, G. Jurik, H. K. Graudal, and P. Garred. 2000. The association of variant mannose-binding lectin genotypes with radiographic outcome in rheumatoid arthritis. Arthritis Rheum.43:515-521.","journal-title":"Arthritis Rheum."},{"key":"e_1_3_2_20_2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1161\/01.CIR.92.3.415","volume":"92","year":"1995","unstructured":"Guilherme, L., E. Cunha-Neto, V. Coelho, R. Snitcowsky, P. M. A. Pomerantzeff, R. V. Assis, F. Pedra, J. Neumann, A. Goldberg, M. E. Patarroyo, F. Pileggi, and J. Kalil. 1995. Human heart-infiltrating T-cell clones from rheumatic heart disease patients recognize both streptococcal and cardiac proteins. Circulation92:415-420.","journal-title":"Circulation"},{"key":"e_1_3_2_21_2","first-page":"1","volume":"7","year":"2005","unstructured":"Guilherme, L., K. Fa\u00e9, S. E. Oshiro, and J. Kalil. 2005. Molecular pathogenesis of rheumatic fever and rheumatic heart disease. Expert Rev. Mol. Med.7:1-15.","journal-title":"Expert Rev. Mol. Med."},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1034\/j.1600-065X.2001.1800108.x","volume":"180","year":"2001","unstructured":"Jack, D. L., N. J. Klein, and M. W. Turner. 2001. Mannose-binding lectin: targeting the microbial world for complement attack and opsonophagocytosis. Immunol. Rev.180:86-99.","journal-title":"Immunol. Rev."},{"key":"e_1_3_2_23_2","first-page":"1","volume":"113","year":"1960","unstructured":"Kaplan, M. H., and F. D. Dallenbach. 1960. Immunologic studies of heart. III. Occurrence of bound gamma globulin in auricular appendages from rheumatic hearts. Relationship to certain histopathic features of rheumatic heart disease. J. Exp. Med.113:1-23.","journal-title":"J. Exp. Med."},{"key":"e_1_3_2_24_2","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1056\/NEJM196409242711301","volume":"271","year":"1964","unstructured":"Kaplan, M. H., R. Bolande, L. Rakita, and J. Blair. 1964. Presence of bound immunoglobulins and complement in the myocardium in acute rheumatic fever. Association with cardiac failure. N. Engl. J. Med.271:637-645.","journal-title":"N. Engl. J. Med."},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.57.8.2457-2461.1989"},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/217173a0","volume":"217","year":"1968","unstructured":"Lannigan, R., and S. A. Zaki. 1968. Location of gamma globulin in the endocardium in rheumatic heart disease by the ferritin-labelled antibody technique. Nature217:173-174.","journal-title":"Nature"},{"key":"e_1_3_2_27_2","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.humimm.2006.08.296","volume":"67","year":"2006","unstructured":"Messias Reason, I. J., M. D. Schafranski, J. C. Jensenius, and R. Steffensen. 2006. The association between mannose-binding lectin gene polymorphism and rheumatic heart disease. Hum. Immunol.67:991-998.","journal-title":"Hum. Immunol."},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.2.688-693.2000"},{"key":"e_1_3_2_29_2","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1056\/NEJMoa033122","volume":"351","year":"2004","unstructured":"\u00d8hlenschlaeger, T., P. Garred, H. O. Madsen, and S. Jacobsen. 2004. Mannose-binding lectin variant alleles and the risk of arterial thrombosis in systemic lupus erythematosus. N. Engl. J. Med.351:260-267.","journal-title":"N. Engl. J. Med."},{"key":"e_1_3_2_30_2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.0300-9475.2004.01437.x","volume":"60","year":"2004","unstructured":"Saevarsdottir, S., T. Vikingsdottir, and H. Valdimarsson. 2004. The potential role of mannan-binding lectin in the clearance of self-components including immune complexes. Scand. J. Immunol.60:23-29.","journal-title":"Scand. J. Immunol."},{"key":"e_1_3_2_31_2","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.4049\/jimmunol.151.7.3902","volume":"151","year":"1993","unstructured":"Shikhman, A. R., N. S. Greenspan, and M. W. Cunningham. 1993. A subset of mouse monoclonal antibodies cross-reactive with cytoskeletal proteins and group A streptococcal M proteins recognizes N-acetyl-beta-d-glucosamine. J. Immunol.151:3902-3913.","journal-title":"J. Immunol."},{"key":"e_1_3_2_32_2","doi-asserted-by":"crossref","first-page":"5593","DOI":"10.4049\/jimmunol.153.12.5593","volume":"153","year":"1994","unstructured":"Shikhman, A. R., N. S. Greenspan, and M. W. Cunningham. 1994. Cytokeratin peptide SFGSGFGGGY mimics N-acetyl-beta-d-glucosamine in reaction with antibodies and lectins, and induces in vivo anti-carbohydrate antibody response. J. Immunol.153:5593-5606.","journal-title":"J. Immunol."},{"key":"e_1_3_2_33_2","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1161\/01.CIR.44.3.368","volume":"44","year":"1971","unstructured":"Spagnuolo, M., H. Kloth, A. Taranta, E. Doyle, and B. Pasternack. 1971. Natural history of rheumatic aortic regurgitation. Criteria predictive of death, congestive heart failure, and angina in young patients. Circulation44:368-380.","journal-title":"Circulation"},{"key":"e_1_3_2_34_2","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1056\/NEJMoa022836","volume":"349","year":"2003","unstructured":"Stengaard-Pedersen, K., S. Thiel, M. Gadjeva, M. M\u00f8ller-Kristensen, R. S\u00f8rensen, L. T. Jensen, A. G. Sj\u00f6holm, L. Fugger, and J. C. Jensenius. 2003. Inherited deficiency of mannan-binding lectin-associated serine protease 2. N. Engl. J. Med.349:554-560.","journal-title":"N. Engl. J. Med."},{"key":"e_1_3_2_35_2","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/0140-6736(91)93263-9","volume":"337","year":"1991","unstructured":"Sumiya, M., M. Super, P. Tabona, R. J. Levinsky, T. Arai, M. W. Turner, and J. A. Summerfield. 1991. Molecular basis of opsonic defect in immunodeficient children. Lancet337:1569-1570.","journal-title":"Lancet"},{"key":"e_1_3_2_36_2","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/S0140-6736(95)90009-8","volume":"345","year":"1995","unstructured":"Summerfield, J. A., S. Ryder, M. Sumiya, M. Thursz, A. Gorchein, M. A. Monteil, and M. W. Turner. 1995. Mannose binding protein gene mutations associated with unusual and severe infections in adults. Lancet345:886-889.","journal-title":"Lancet"},{"key":"e_1_3_2_37_2","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.molimm.2005.06.018","volume":"43","year":"2006","unstructured":"Thiel, S., P. D. Frederiksen, and J. C. Jensenius. 2006. Clinical manifestations of mannan-binding lectin deficiency. Mol. Immunol.43:86-96.","journal-title":"Mol. Immunol."},{"key":"e_1_3_2_38_2","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/sj.gene.6364373","volume":"8","year":"2007","unstructured":"Thiel, S., R. Steffensen, I. J. Christensen, W. K. Ip, Y. L. Lau, I. J. Reason, H. Eiberg, M. Gadjeva, M. Ruseva, and J. C. Jensenius. 2007. Deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms. Genes Immun.8:154-163.","journal-title":"Genes Immun."},{"key":"e_1_3_2_39_2","first-page":"305","volume":"2","year":"2000","unstructured":"Turner, M. W., and R. M. Hamvas. 2000. Mannose-binding lectin: structure, function, genetics and disease associations. Rev. Immunogenet.2:305-322.","journal-title":"Rev. Immunogenet."},{"key":"e_1_3_2_40_2","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1084\/jem.146.2.579","volume":"146","year":"1977","unstructured":"van de Rijn, I., J. B. Zabriskie, and M. McCarty. 1977. Group A streptococcal antigens cross-reactive with myocardium. Purification of heart-reactive antibody and isolation and characterization of the streptococcal antigen. J. Exp. Med.146:579-599.","journal-title":"J. Exp. Med."},{"key":"e_1_3_2_41_2","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.4049\/jimmunol.165.4.2093","volume":"165","year":"2000","unstructured":"Vorup-Jensen, T., S. V. Petersen, A. G. Hansen, K. Poulsen, W. Schwaeble, R. B. Sim, K. B. Reid, S. J. Davis, S. Thiel, and J. C. Jensenius. 2000. Distinct pathways of mannan-binding lectin (MBL)- and C1-complex autoactivation revealed by reconstitution of MBL with MBL-associated serine protease-2. J. Immunol.165:2093-2100.","journal-title":"J. Immunol."}],"container-title":["Clinical and Vaccine Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00324-07","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00324-07","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T15:32:59Z","timestamp":1684337579000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/CVI.00324-07"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1128\/CVI.00324-07"],"URL":"https:\/\/doi.org\/10.1128\/cvi.00324-07","relation":{},"ISSN":["1556-6811","1556-679X"],"issn-type":[{"value":"1556-6811","type":"print"},{"value":"1556-679X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6]]},"assertion":[{"value":"2007-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-03-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}