{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:43:10Z","timestamp":1790257390710,"version":"4.1.0"},"reference-count":13,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Histoplasmosis is a common endemic mycosis in the Americas, often causing severe disease in patients with AIDS. Antigen detection has become an important method for rapid diagnosis of histoplasmosis in the United States but not in Central or South America. Isolates from patients in the United States are predominantly found to be class 2 isolates when typed using the nuclear gene\n            <jats:italic>YPS3<\/jats:italic>\n            , while isolates from Latin America are predominantly typed as class 5 or class 6. Whether infection with these Latin American genotypes produces positive results in the\n            <jats:italic>Histoplasma<\/jats:italic>\n            antigen assay has not been reported. In this study, we have compared the sensitivity of antigen detection for AIDS patients from Panama who had progressive disseminated histoplasmosis to that for those in the United States. Antigenuria was detected in the MVista\n            <jats:italic>Histoplasma<\/jats:italic>\n            antigen enzyme immunoassay (EIA) in 95.2% of Panamanian cases versus 100% of U.S. cases. Antigenemia was detected in 94.7% of the Panamanian cases versus 92% of the U.S. cases. Two clinical isolates from Panama were typed using\n            <jats:italic>YPS3<\/jats:italic>\n            and were found to be restriction fragment length polymorphism class 6. We conclude that the MVista\n            <jats:italic>Histoplasma<\/jats:italic>\n            antigen EIA is a sensitive method for diagnosis of histoplasmosis in Panama.\n          <\/jats:p>","DOI":"10.1128\/cvi.00358-07","type":"journal-article","created":{"date-parts":[[2008,2,21]],"date-time":"2008-02-21T02:38:31Z","timestamp":1203561511000},"page":"681-683","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Detection of\n            <i>Histoplasma capsulatum<\/i>\n            Antigen in Panamanian Patients with Disseminated Histoplasmosis and AIDS"],"prefix":"10.1128","volume":"15","author":[{"given":"Maria Eugenia","family":"Gutierrez","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Arnulfo Arias Madrid Hospital, Panama City, Panama"},{"name":"MiraVista Diagnostics, Indianapolis, Indiana"},{"name":"Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Canton","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Arnulfo Arias Madrid Hospital, Panama City, Panama"},{"name":"MiraVista Diagnostics, Indianapolis, Indiana"},{"name":"Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Connolly","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Arnulfo Arias Madrid Hospital, Panama City, Panama"},{"name":"MiraVista Diagnostics, Indianapolis, Indiana"},{"name":"Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Zarnowski","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Arnulfo Arias Madrid Hospital, Panama City, Panama"},{"name":"MiraVista Diagnostics, Indianapolis, Indiana"},{"name":"Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Joseph","family":"Wheat","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Arnulfo Arias Madrid Hospital, Panama City, Panama"},{"name":"MiraVista Diagnostics, Indianapolis, Indiana"},{"name":"Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","unstructured":"Antigen detection of Latin American strains of Histoplasma in a murine model 2007"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/323335"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00010-07"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00071-07"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.9.4370-4373.2004"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1086\/428842","volume":"40","year":"2005","unstructured":"Gutierrez, M. E., A. Canton, N. Sosa, E. Puga, and L. Talavera. 2005. Disseminated histoplasmosis in patients with AIDS in Panama: a review of 104 cases. Clin. Infect. Dis.40:1199-1202.","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1086\/345724","volume":"186","year":"2002","unstructured":"Karimi, K., L. J. Wheat, P. Connolly, G. Cloud, R. Hajjeh, E. Wheat, K. Alves, C. S. Lacaz Cd, and E. Keath. 2002. Differences in histoplasmosis in patients with acquired immunodeficiency syndrome in the United States and Brazil. J. Infect. Dis.186:1655-1660.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1046\/j.1365-294X.2003.01995.x","volume":"12","year":"2003","unstructured":"Kasuga, T., T. J. White, G. Koenig, J. McEwen, A. Restrepo, E. Castaneda, L. C. Da Silva, E. M. Heins-Vaccari, R. S. De Freitas, R. M. Zancope-Oliveira, Z. Qin, R. Negroni, D. A. Carter, Y. Mikami, M. Tamura, M. L. Taylor, G. F. Miller, N. Poonwan, and J. W. Taylor. 2003. Phylogeography of the fungal pathogen Histoplasma capsulatum. Mol. Ecol.12:3383-3401.","journal-title":"Mol. Ecol."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.30.8.2104-2107.1992"},{"key":"e_1_3_2_11_2","first-page":"e50-e54","volume":"44","year":"2007","unstructured":"Kuberski, T., R. Myers, L. J. Wheat, B. M. Kubak, D. Bruckner, and D. Peuges. 2007. Diagnosis of coccidioidomycosis by antigen detection using cross-reaction with a Histoplasma antigen. Clin. Infect. Dis.44:e50-e54.","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0002-9343(97)00151-4","volume":"103","year":"1997","unstructured":"Wheat, J., S. MaWhinney, R. Hafner, D. McKinsey, D. Chen, A. Korzun, K. J. Shakan, P. Johnson, R. Hamill, D. Bamberger, P. Pappas, J. Stansell, S. Koletar, K. Squires, R. A. Larsen, T. Cheung, N. Hyslop, K. K. Lai, D. Schneider, C. Kauffman, M. Saag, W. Dismukes, W. Powderly, et al. 1997. Treatment of histoplasmosis with fluconazole in patients with acquired immunodeficiency syndrome. Am. J. Med.103:223-232.","journal-title":"Am. J. Med."},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1086\/513647","volume":"24","year":"1997","unstructured":"Wheat, J., H. Wheat, P. Connolly, M. Kleiman, K. Supparatpinyo, K. Nelson, R. Bradsher, and A. Restrepo. 1997. Cross-reactivity in Histoplasma capsulatum variety capsulatum antigen assays of urine samples from patients with endemic mycoses. Clin. Infect. Dis.24:1169-1171.","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_2_14_2","first-page":"1205","volume":"118","year":"1994","unstructured":"Williams, B., M. Fojtasek, P. Connolly-Stringfield, and J. Wheat. 1994. Diagnosis of histoplasmosis by antigen detection during an outbreak in Indianapolis, Ind. Arch. Pathol. Lab. Med.118:1205-1208.","journal-title":"Arch. Pathol. Lab. Med."}],"container-title":["Clinical and Vaccine Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00358-07","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00358-07","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T20:39:40Z","timestamp":1627591180000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/CVI.00358-07"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1128\/CVI.00358-07"],"URL":"https:\/\/doi.org\/10.1128\/cvi.00358-07","relation":{},"ISSN":["1556-6811","1556-679X"],"issn-type":[{"value":"1556-6811","type":"print"},{"value":"1556-679X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4]]},"assertion":[{"value":"2007-09-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-02-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}