{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T19:18:14Z","timestamp":1774379894045,"version":"3.50.1"},"reference-count":14,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>DNA vaccines encoding different portions of the structural proteins of western equine encephalitis virus were tested for the efficacy of their protection in a 100% lethal mouse model of the virus. The 6K-E1 structural protein encoded by the DNA vaccine conferred complete protection against challenge with the homologous strain and limited protection against challenge with a heterologous strain.<\/jats:p>","DOI":"10.1128\/cvi.00377-09","type":"journal-article","created":{"date-parts":[[2009,11,19]],"date-time":"2009-11-19T03:34:15Z","timestamp":1258601655000},"page":"176-179","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Identification of Western Equine Encephalitis Virus Structural Proteins That Confer Protection after DNA Vaccination"],"prefix":"10.1128","volume":"17","author":[{"given":"Penelope J.","family":"Gauci","sequence":"first","affiliation":[{"name":"Human Protection and Performance Division, Defence Science and Technology Organization, 506 Lorimer St., Fishermans Bend, Victoria 3207, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josh Q. H.","family":"Wu","sequence":"additional","affiliation":[{"name":"Biotechnology Section, Defence Research and Development Canada\u2014Suffield, Suffield, Alberta T1A 8K6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George A.","family":"Rayner","sequence":"additional","affiliation":[{"name":"Biotechnology Section, Defence Research and Development Canada\u2014Suffield, Suffield, Alberta T1A 8K6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole D.","family":"Barabe\u0301","sequence":"additional","affiliation":[{"name":"Biotechnology Section, Defence Research and Development Canada\u2014Suffield, Suffield, Alberta T1A 8K6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie P.","family":"Nagata","sequence":"additional","affiliation":[{"name":"Biotechnology Section, Defence Research and Development Canada\u2014Suffield, Suffield, Alberta T1A 8K6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David F.","family":"Proll","sequence":"additional","affiliation":[{"name":"Human Protection and Performance Division, Defence Science and Technology Organization, 506 Lorimer St., Fishermans Bend, Victoria 3207, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.antiviral.2004.06.008","volume":"64","year":"2004","unstructured":"Das, D., S. L. Gares, L. P. Nagata, and M. R. Suresh. 2004. Evaluation of a western equine encephalitis recombinant E1 protein for protective immunity and diagnostics. Antivir. Res.64:85-92.","journal-title":"Antivir. Res."},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1046-2023(03)00135-X","volume":"31","year":"2003","unstructured":"Doria-Rose, N. A., and N. L. Haigwood. 2003. DNA vaccine strategies: candidates for immune modulation and immunization regimens. Methods31:207-216.","journal-title":"Methods"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01576-07"},{"key":"e_1_3_2_5_2","first-page":"1023","volume":"1","year":"2007","unstructured":"Griffin, D. E. 2007. Alphaviruses, p. 1023-1067. In D. M. Knipe and P. M. Howley (ed.), Fields virology,vol. 1, 5th ed. Lippincott Williams & Wilkins, Philadelphia, PA.","journal-title":"Fields virology"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/S0264-410X(98)00335-1","volume":"17","year":"1999","unstructured":"Hodgson, L. A., G. V. Ludwig, and J. F. Smith. 1999. Expression, processing, and immunogenicity of the structural proteins of Venezuelan equine encephalitis virus from recombinant baculovirus vectors. Vaccine17:1151-1160.","journal-title":"Vaccine"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1038\/mt.2009.130","volume":"17","year":"2009","unstructured":"Lasaro, M. O., and H. C. Ertl. 2009. New insights on adenovirus as vaccine vectors. Mol. Ther.17:1333-1339.","journal-title":"Mol. Ther."},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1099\/vir.0.008656-0","volume":"90","year":"2009","unstructured":"Logue, C. H., C. F. Bosio, T. Welte, K. M. Keene, J. P. Ledermann, A. Phillips, B. J. Sheahan, D. J. Pierro, N. Marlenee, A. C. Brault, C. M. Bosio, A. J. Singh, A. M. Powers, and K. E. Olson. 2009. Virulence variation among isolates of western equine encephalitis virus in an outbred mouse model. J. Gen. Virol.90:1848-1858.","journal-title":"J. Gen. Virol."},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1089\/02724570050031158","volume":"19","year":"2000","unstructured":"Long, M. C., L. P. Nagata, G. V. Ludwig, A. Z. Alvi, J. D. Conley, A. R. Bhatti, M. R. Suresh, and R. E. Fulton. 2000. Construction and characterization of monoclonal antibodies against western equine encephalitis virus. Hybridoma19:121-127.","journal-title":"Hybridoma"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1016\/j.vaccine.2005.01.032","volume":"23","year":"2005","unstructured":"Nagata, L. P., W. G. Hu, S. A. Masri, G. A. Rayner, F. L. Schmaltz, D. Das, J. Wu, M. C. Long, C. Chan, D. Proll, S. Jager, L. Jebailey, M. R. Suresh, and J. P. Wong. 2005. Efficacy of DNA vaccination against western equine encephalitis virus infection. Vaccine23:2280-2283.","journal-title":"Vaccine"},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1099\/vir.0.81815-0","volume":"87","year":"2006","unstructured":"Nagata, L. P., W. G. Hu, M. Parker, D. Chau, G. A. Rayner, F. L. Schmaltz, and J. P. Wong. 2006. Infectivity variation and genetic diversity among strains of Western equine encephalitis virus. J. Gen. Virol.87:2353-2361.","journal-title":"J. Gen. Virol."},{"key":"e_1_3_2_12_2","first-page":"151","volume":"81","year":"2000","unstructured":"Netolitzky, D. J., F. L. Schmaltz, M. D. Parker, G. A. Rayner, G. R. Fisher, D. W. Trent, D. E. Bader, and L. P. Nagata. 2000. Complete genomic RNA sequence of western equine encephalitis virus and expression of the structural genes. J. Gen. Virol.81:151-159.","journal-title":"J. Gen. Virol."},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/j.vaccine.2006.02.020","volume":"24","year":"2006","unstructured":"Perkins, S. D., L. M. O'Brien, and R. J. Phillpotts. 2006. Boosting with an adenovirus-based vaccine improves protective efficacy against Venezuelan equine encephalitis virus following DNA vaccination. Vaccine24:3440-3445.","journal-title":"Vaccine"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/j.vaccine.2004.06.056","volume":"23","year":"2005","unstructured":"Phillpotts, R. J., L. O'Brien, R. E. Appleton, S. Carr, and A. Bennett. 2005. Intranasal immunisation with defective adenovirus serotype 5 expressing the Venezuelan equine encephalitis virus E2 glycoprotein protects against airborne challenge with virulent virus. Vaccine23:1615-1623.","journal-title":"Vaccine"},{"key":"e_1_3_2_15_2","first-page":"1000","volume":"1","year":"2007","unstructured":"Richard, J. K. 2007. Togaviridae: the viruses and their replication, p. 1000-1022. In D. M. Knipe and P. M. Howley (ed.), Fields virology,vol. 1, 5th ed. Lippincott Williams & Wilkins, Philadelphia, PA.","journal-title":"Fields virology"}],"container-title":["Clinical and Vaccine Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00377-09","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00377-09","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T20:42:41Z","timestamp":1627591361000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/CVI.00377-09"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["10.1128\/CVI.00377-09"],"URL":"https:\/\/doi.org\/10.1128\/cvi.00377-09","relation":{},"ISSN":["1556-6811","1556-679X"],"issn-type":[{"value":"1556-6811","type":"print"},{"value":"1556-679X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1]]},"assertion":[{"value":"2009-09-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-11-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}