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The objective of this study was to assess the possible association between polymorphisms of the<jats:italic>MBL2<\/jats:italic>gene and the incidence of septic shock and bacteremia in patients with acute pyelonephritis due to<jats:italic>Escherichia coli<\/jats:italic>. The study included 62 female patients with acute pyelonephritis due to<jats:italic>E. coli<\/jats:italic>who required hospital admission, as well as 133 healthy control subjects. Six single-nucleotide polymorphisms (\u2212550 G\/C, \u2212221 C\/G, +4 C\/T, codon 52 CGT\/TGT, codon 54 GGC\/GAC, and codon 57 GGA\/GAA) in the<jats:italic>MBL2<\/jats:italic>gene were genotyped by using a sequence-based typing technique. No significant differences were observed in the frequencies for low-expression<jats:italic>MBL2<\/jats:italic>genotypes (O\/O and LXA\/O) between patients with acute pyelonephritis and healthy controls. Patients with acute pyelonephritis and septic shock had a higher incidence of low-expression<jats:italic>MBL2<\/jats:italic>genotypes than patients with acute pyelonephritis without septic shock (odds ratio = 9.019, 95% confidence interval = 1.23 to 65.93;<jats:italic>P<\/jats:italic>= 0.03). No association was found between bacteremic acute pyelonephritis and low-expression<jats:italic>MBL2<\/jats:italic>genotypes. We found that low-expression<jats:italic>MBL2<\/jats:italic>genotypes predispose to septic shock but not to bacteremia in patients with<jats:italic>E. coli<\/jats:italic>-induced acute pyelonephritis. Determination of<jats:italic>MBL2<\/jats:italic>polymorphisms could be useful for assessing the risk of septic shock in women undergoing acute pyelonephritis.<\/jats:p>","DOI":"10.1128\/cvi.00400-06","type":"journal-article","created":{"date-parts":[[2007,1,4]],"date-time":"2007-01-04T06:30:07Z","timestamp":1167892207000},"page":"256-261","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Association between Mannose-Binding Lectin Deficiency and Septic Shock following Acute Pyelonephritis Due to<i>Escherichia coli<\/i>"],"prefix":"10.1128","volume":"14","author":[{"given":"Alex","family":"Smithson","sequence":"first","affiliation":[{"name":"Infectious Diseases Unit"},{"name":"Department of Immunology"},{"name":"Department of Microbiology, Hospital Cli\u0301nic, IDIBAPS, University of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Mun\u0303oz","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit"},{"name":"Department of Immunology"},{"name":"Department of Microbiology, Hospital Cli\u0301nic, IDIBAPS, University of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belen","family":"Suarez","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit"},{"name":"Department of Immunology"},{"name":"Department of Microbiology, Hospital Cli\u0301nic, IDIBAPS, University of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Maria","family":"Soto","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit"},{"name":"Department of Immunology"},{"name":"Department of Microbiology, Hospital Cli\u0301nic, IDIBAPS, University of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Perello","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit"},{"name":"Department of Immunology"},{"name":"Department of Microbiology, Hospital Cli\u0301nic, IDIBAPS, University of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Soriano","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit"},{"name":"Department of Immunology"},{"name":"Department of Microbiology, Hospital Cli\u0301nic, IDIBAPS, University of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Antonio","family":"Martinez","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit"},{"name":"Department of Immunology"},{"name":"Department of Microbiology, Hospital Cli\u0301nic, IDIBAPS, University of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Vila","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit"},{"name":"Department of Immunology"},{"name":"Department of Microbiology, Hospital Cli\u0301nic, IDIBAPS, University of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Pablo","family":"Horcajada","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit"},{"name":"Department of Immunology"},{"name":"Department of Microbiology, Hospital Cli\u0301nic, IDIBAPS, University of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Mensa","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit"},{"name":"Department of Immunology"},{"name":"Department of Microbiology, Hospital Cli\u0301nic, IDIBAPS, University of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Lozano","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit"},{"name":"Department of Immunology"},{"name":"Department of Microbiology, Hospital Cli\u0301nic, IDIBAPS, University of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1365-2249.2005.02881.x","volume":"142","year":"2005","unstructured":"Aittoniemi, J., H. 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