{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T05:43:46Z","timestamp":1773812626069,"version":"3.50.1"},"reference-count":34,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Hookworm infection is one of most important parasitic infection of humans, occurring in 740 million people. Here we report the protective vaccination of dogs with\n            <jats:italic>Ac<\/jats:italic>\n            -16, an immunodominant surface antigen from the hookworm\n            <jats:italic>Ancylostoma caninum<\/jats:italic>\n            . We show that immunization with\n            <jats:italic>Ac<\/jats:italic>\n            -16 formulated with AS03 elicited specific humoral and cellular immune responses and provided partial protection against hookworm infection and morbidity as evidenced by a significant reduction of hookworm egg counts (64% reduction;\n            <jats:italic>P<\/jats:italic>\n            = 0.0078) and worm-induced blood loss (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.05). Moreover, specific anti-\n            <jats:italic>Ac<\/jats:italic>\n            -16 antibodies recognized the native protein on the surface of third-stage larvae and blocked their migration through tissue in vitro. Our data support the use of\n            <jats:italic>Ac<\/jats:italic>\n            -16 as a potential candidate for vaccination against hookworm infection.\n          <\/jats:p>","DOI":"10.1128\/cvi.00404-06","type":"journal-article","created":{"date-parts":[[2007,2,3]],"date-time":"2007-02-03T02:42:28Z","timestamp":1170470548000},"page":"281-287","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":26,"title":["Reduction of Worm Fecundity and Canine Host Blood Loss Mediates Protection against Hookworm Infection Elicited by Vaccination with Recombinant\n            <i>Ac-<\/i>\n            16"],"prefix":"10.1128","volume":"14","author":[{"given":"Ricardo T.","family":"Fujiwara","sequence":"first","affiliation":[{"name":"Human Hookworm Vaccine Initiative, Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington, DC"},{"name":"Cellular and Molecular Immunology Laboratory, Centro de Pesquisas Rene\u0301 Rachou, FIOCRUZ, Minas Gerais, Brazil"},{"name":"Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York"},{"name":"Queensland Institute of Medical Research, Brisbane, Australia"},{"name":"Department of Parasitology, Instituto de Cie\u0302ncias Biolo\u0301gicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Zhan","sequence":"additional","affiliation":[{"name":"Human Hookworm Vaccine Initiative, Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington, DC"},{"name":"Cellular and Molecular Immunology Laboratory, Centro de Pesquisas Rene\u0301 Rachou, FIOCRUZ, Minas Gerais, Brazil"},{"name":"Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York"},{"name":"Queensland Institute of Medical Research, Brisbane, Australia"},{"name":"Department of Parasitology, Instituto de Cie\u0302ncias Biolo\u0301gicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Mendez","sequence":"additional","affiliation":[{"name":"Human Hookworm Vaccine Initiative, Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington, DC"},{"name":"Cellular and Molecular Immunology Laboratory, Centro de Pesquisas Rene\u0301 Rachou, FIOCRUZ, Minas Gerais, Brazil"},{"name":"Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York"},{"name":"Queensland Institute of Medical Research, Brisbane, Australia"},{"name":"Department of Parasitology, Instituto de Cie\u0302ncias Biolo\u0301gicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Loukas","sequence":"additional","affiliation":[{"name":"Human Hookworm Vaccine Initiative, Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington, DC"},{"name":"Cellular and Molecular Immunology Laboratory, Centro de Pesquisas Rene\u0301 Rachou, FIOCRUZ, Minas Gerais, Brazil"},{"name":"Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York"},{"name":"Queensland Institute of Medical Research, Brisbane, Australia"},{"name":"Department of Parasitology, Instituto de Cie\u0302ncias Biolo\u0301gicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilian L.","family":"Bueno","sequence":"additional","affiliation":[{"name":"Human Hookworm Vaccine Initiative, Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington, DC"},{"name":"Cellular and Molecular Immunology Laboratory, Centro de Pesquisas Rene\u0301 Rachou, FIOCRUZ, Minas Gerais, Brazil"},{"name":"Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York"},{"name":"Queensland Institute of Medical Research, Brisbane, Australia"},{"name":"Department of Parasitology, Instituto de Cie\u0302ncias Biolo\u0301gicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Human Hookworm Vaccine Initiative, Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington, DC"},{"name":"Cellular and Molecular Immunology Laboratory, Centro de Pesquisas Rene\u0301 Rachou, FIOCRUZ, Minas Gerais, Brazil"},{"name":"Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York"},{"name":"Queensland Institute of Medical Research, Brisbane, Australia"},{"name":"Department of Parasitology, Instituto de Cie\u0302ncias Biolo\u0301gicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan","family":"Plieskatt","sequence":"additional","affiliation":[{"name":"Human Hookworm Vaccine Initiative, Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington, DC"},{"name":"Cellular and Molecular Immunology Laboratory, Centro de Pesquisas Rene\u0301 Rachou, FIOCRUZ, Minas Gerais, Brazil"},{"name":"Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York"},{"name":"Queensland Institute of Medical Research, Brisbane, Australia"},{"name":"Department of Parasitology, Instituto de Cie\u0302ncias Biolo\u0301gicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yelena","family":"Oksov","sequence":"additional","affiliation":[{"name":"Human Hookworm Vaccine Initiative, Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington, DC"},{"name":"Cellular and Molecular Immunology Laboratory, Centro de Pesquisas Rene\u0301 Rachou, FIOCRUZ, Minas Gerais, Brazil"},{"name":"Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York"},{"name":"Queensland Institute of Medical Research, Brisbane, Australia"},{"name":"Department of Parasitology, Instituto de Cie\u0302ncias Biolo\u0301gicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Lustigman","sequence":"additional","affiliation":[{"name":"Human Hookworm Vaccine Initiative, Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington, DC"},{"name":"Cellular and Molecular Immunology Laboratory, Centro de Pesquisas Rene\u0301 Rachou, FIOCRUZ, Minas Gerais, Brazil"},{"name":"Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York"},{"name":"Queensland Institute of Medical Research, Brisbane, Australia"},{"name":"Department of Parasitology, Instituto de Cie\u0302ncias Biolo\u0301gicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Elena","family":"Bottazzi","sequence":"additional","affiliation":[{"name":"Human Hookworm Vaccine Initiative, Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington, DC"},{"name":"Cellular and Molecular Immunology Laboratory, Centro de Pesquisas Rene\u0301 Rachou, FIOCRUZ, Minas Gerais, Brazil"},{"name":"Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York"},{"name":"Queensland Institute of Medical Research, Brisbane, Australia"},{"name":"Department of Parasitology, Instituto de Cie\u0302ncias Biolo\u0301gicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Hotez","sequence":"additional","affiliation":[{"name":"Human Hookworm Vaccine Initiative, Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington, DC"},{"name":"Cellular and Molecular Immunology Laboratory, Centro de Pesquisas Rene\u0301 Rachou, FIOCRUZ, Minas Gerais, Brazil"},{"name":"Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York"},{"name":"Queensland Institute of Medical Research, Brisbane, Australia"},{"name":"Department of Parasitology, Instituto de Cie\u0302ncias Biolo\u0301gicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey M.","family":"Bethony","sequence":"additional","affiliation":[{"name":"Human Hookworm Vaccine Initiative, Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington, DC"},{"name":"Cellular and Molecular Immunology Laboratory, Centro de Pesquisas Rene\u0301 Rachou, FIOCRUZ, Minas Gerais, Brazil"},{"name":"Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York"},{"name":"Queensland Institute of Medical Research, Brisbane, Australia"},{"name":"Department of Parasitology, Instituto de Cie\u0302ncias Biolo\u0301gicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"343","volume":"81","year":"2003","unstructured":"Albonico, M., Q. 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Parasitol.88:684-690.","journal-title":"J. Parasitol."},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/S0020-7519(03)00158-9","volume":"33","year":"2003","unstructured":"Hotez, P. J., B. Zhan, J. M. Bethony, A. Loukas, A. Williamson, G. N. Goud, J. M. Hawdon, A. Dobardzic, R. Dobardzic, K. Ghosh, M. E. Bottazzi, S. Mendez, B. Zook, Y. Wang, S. Liu, I. Essiet-Gibson, S. Chung-Debose, S. Xiao, D. Knox, M. Meagher, M. Inan, R. Correa-Oliveira, P. Vilk, H. R. Shepherd, W. Brandt, and P. K. Russell. 2003. Progress in the development of a recombinant vaccine for human hookworm disease: the Human Hookworm Vaccine Initiative. Int. J. Parasitol.33:1245-1258.","journal-title":"Int. J. Parasitol."},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1163\/156854100750112833","volume":"2","year":"2000","unstructured":"Jones, J. T., G. Smant, and V. C. Block. 2000. 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