{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:58:36Z","timestamp":1790863116543,"version":"4.1.0"},"reference-count":27,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study investigated the use of two doses of three different meningococcal group C conjugate (MCC) vaccines when given for primary immunization with a seven-valent pneumococcal conjugate vaccine (PCV7) and Pediacel, a combination product containing five acellular pertussis components, diphtheria and tetanus toxoids,\n                    <jats:italic>Haemophilus influenzae<\/jats:italic>\n                    type b (Hib) conjugate, and inactivated-poliovirus vaccine. The immune response after a single dose of MCC is also presented. Infants were randomized to receive two doses of one of the MCC vaccines and PCV7 at 2 and 3 months or at 2 and 4 months of age. Meningococcal group C serum bactericidal antibody (SBA) geometric mean titers, Hib-polyribosylribitol phosphate (PRP) immunoglobulin G (IgG) geometric mean concentrations (GMCs), and diphtheria and tetanus antitoxin GMCs, together with the proportions of infants achieving putative protective levels, were determined. A total of 393 infants were recruited. Following the first dose of NeisVac-C (MCC conjugated to tetanus toxoid), 97% of infants achieved protective levels (SBA titer of \u22658), compared with 80% and 53%, respectively, for Menjugate and Meningitec (both of which are conjugated to CRM\n                    <jats:sub>197<\/jats:sub>\n                    ). SBA responses to MCC vaccines were not significantly different when administered at 2 and 3 or 2 and 4 months of age. Following two doses of each MCC, 98 to 100% of infants achieved protective levels. Both PRP IgG and tetanus responses were significantly enhanced when Pediacel was coadministered with NeisVac-C. This study demonstrates that NeisVac-C and Menjugate generate good immunogenicity after the first dose at 2 months of age when coadministered with PCV7 and Pediacel and merit further investigation in single-dose priming strategies.\n                  <\/jats:p>","DOI":"10.1128\/cvi.00420-08","type":"journal-article","created":{"date-parts":[[2008,12,18]],"date-time":"2008-12-18T11:04:23Z","timestamp":1229598263000},"page":"194-199","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":57,"title":["Immunogenicity of a Reduced Schedule of Meningococcal Group C Conjugate Vaccine Given Concomitantly with the Prevenar and Pediacel Vaccines in Healthy Infants in the United Kingdom"],"prefix":"10.1128","volume":"16","author":[{"given":"Jo","family":"Southern","sequence":"first","affiliation":[{"name":"Immunisation Department, Centre for Infections, Health Protection Agency, Colindale, London NW9 5EQ, United Kingdom"},{"name":"Vaccine Evaluation Unit, Health Protection Agency, Manchester Medical Microbiology Partnership, P.O. Box 209, Clinical Sciences Building 2, Manchester Royal Infirmary, Manchester M13 9WZ, United Kingdom"},{"name":"Statistics, Modeling and Economics Department, Centre for Infections, Health Protection Agency, Colindale, London NW9 5EQ, United Kingdom"},{"name":"Gloucester Vaccine Evaluation Unit, Health Protection Agency, Gloucestershire Royal Hospital, Gloucester, United Kingdom"},{"name":"Immunoassay Laboratory, Centre for Emergency Preparedness and Response, Health Protection Agency, Porton Down, Salisbury, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ray","family":"Borrow","sequence":"additional","affiliation":[{"name":"Immunisation Department, Centre for Infections, Health Protection Agency, Colindale, London NW9 5EQ, United Kingdom"},{"name":"Vaccine Evaluation Unit, Health Protection Agency, Manchester Medical Microbiology Partnership, P.O. Box 209, Clinical Sciences Building 2, Manchester Royal Infirmary, Manchester M13 9WZ, United Kingdom"},{"name":"Statistics, Modeling and Economics Department, Centre for Infections, Health Protection Agency, Colindale, London NW9 5EQ, United Kingdom"},{"name":"Gloucester Vaccine Evaluation Unit, Health Protection Agency, Gloucestershire Royal Hospital, Gloucester, United Kingdom"},{"name":"Immunoassay Laboratory, Centre for Emergency Preparedness and Response, Health Protection Agency, Porton Down, Salisbury, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Andrews","sequence":"additional","affiliation":[{"name":"Immunisation Department, Centre for Infections, Health Protection Agency, Colindale, London NW9 5EQ, United Kingdom"},{"name":"Vaccine Evaluation Unit, Health Protection Agency, Manchester Medical Microbiology Partnership, P.O. Box 209, Clinical Sciences Building 2, Manchester Royal Infirmary, Manchester M13 9WZ, United Kingdom"},{"name":"Statistics, Modeling and Economics Department, Centre for Infections, Health Protection Agency, Colindale, London NW9 5EQ, United Kingdom"},{"name":"Gloucester Vaccine Evaluation Unit, Health Protection Agency, Gloucestershire Royal Hospital, Gloucester, United Kingdom"},{"name":"Immunoassay Laboratory, Centre for Emergency Preparedness and Response, Health Protection Agency, Porton Down, Salisbury, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhonwen","family":"Morris","sequence":"additional","affiliation":[{"name":"Immunisation Department, Centre for Infections, Health Protection Agency, Colindale, London NW9 5EQ, United Kingdom"},{"name":"Vaccine Evaluation Unit, Health Protection Agency, Manchester Medical Microbiology Partnership, P.O. Box 209, Clinical Sciences Building 2, Manchester Royal Infirmary, Manchester M13 9WZ, United Kingdom"},{"name":"Statistics, Modeling and Economics Department, Centre for Infections, Health Protection Agency, Colindale, London NW9 5EQ, United Kingdom"},{"name":"Gloucester Vaccine Evaluation Unit, Health Protection Agency, Gloucestershire Royal Hospital, Gloucester, United Kingdom"},{"name":"Immunoassay Laboratory, Centre for Emergency Preparedness and Response, Health Protection Agency, Porton Down, Salisbury, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Waight","sequence":"additional","affiliation":[{"name":"Immunisation Department, Centre for Infections, Health Protection Agency, Colindale, London NW9 5EQ, United Kingdom"},{"name":"Vaccine Evaluation Unit, Health Protection Agency, Manchester Medical Microbiology Partnership, P.O. Box 209, Clinical Sciences Building 2, Manchester Royal Infirmary, Manchester M13 9WZ, United Kingdom"},{"name":"Statistics, Modeling and Economics Department, Centre for Infections, Health Protection Agency, Colindale, London NW9 5EQ, United Kingdom"},{"name":"Gloucester Vaccine Evaluation Unit, Health Protection Agency, Gloucestershire Royal Hospital, Gloucester, United Kingdom"},{"name":"Immunoassay Laboratory, Centre for Emergency Preparedness and Response, Health Protection Agency, Porton Down, Salisbury, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hudson","sequence":"additional","affiliation":[{"name":"Immunisation Department, Centre for Infections, Health Protection Agency, Colindale, London NW9 5EQ, United Kingdom"},{"name":"Vaccine Evaluation Unit, Health Protection Agency, Manchester Medical Microbiology Partnership, P.O. Box 209, Clinical Sciences Building 2, Manchester Royal Infirmary, Manchester M13 9WZ, United Kingdom"},{"name":"Statistics, Modeling and Economics Department, Centre for Infections, Health Protection Agency, Colindale, London NW9 5EQ, United Kingdom"},{"name":"Gloucester Vaccine Evaluation Unit, Health Protection Agency, Gloucestershire Royal Hospital, Gloucester, United Kingdom"},{"name":"Immunoassay Laboratory, Centre for Emergency Preparedness and Response, Health Protection Agency, Porton Down, Salisbury, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Balmer","sequence":"additional","affiliation":[{"name":"Immunisation Department, Centre for Infections, Health Protection Agency, Colindale, London NW9 5EQ, United Kingdom"},{"name":"Vaccine Evaluation Unit, Health Protection Agency, Manchester Medical Microbiology Partnership, P.O. Box 209, Clinical Sciences Building 2, Manchester Royal Infirmary, Manchester M13 9WZ, United Kingdom"},{"name":"Statistics, Modeling and Economics Department, Centre for Infections, Health Protection Agency, Colindale, London NW9 5EQ, United Kingdom"},{"name":"Gloucester Vaccine Evaluation Unit, Health Protection Agency, Gloucestershire Royal Hospital, Gloucester, United Kingdom"},{"name":"Immunoassay Laboratory, Centre for Emergency Preparedness and Response, Health Protection Agency, Porton Down, Salisbury, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Findlow","sequence":"additional","affiliation":[{"name":"Immunisation Department, Centre for Infections, Health Protection Agency, Colindale, London NW9 5EQ, United Kingdom"},{"name":"Vaccine Evaluation Unit, Health Protection Agency, Manchester Medical Microbiology Partnership, P.O. Box 209, Clinical Sciences Building 2, Manchester Royal Infirmary, Manchester M13 9WZ, United Kingdom"},{"name":"Statistics, Modeling and Economics Department, Centre for Infections, Health Protection Agency, Colindale, London NW9 5EQ, United Kingdom"},{"name":"Gloucester Vaccine Evaluation Unit, Health Protection Agency, Gloucestershire Royal Hospital, Gloucester, United Kingdom"},{"name":"Immunoassay Laboratory, Centre for Emergency Preparedness and Response, Health Protection Agency, Porton Down, Salisbury, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Findlow","sequence":"additional","affiliation":[{"name":"Immunisation Department, Centre for Infections, Health Protection Agency, Colindale, London NW9 5EQ, United Kingdom"},{"name":"Vaccine Evaluation Unit, Health Protection Agency, Manchester Medical Microbiology Partnership, P.O. Box 209, Clinical Sciences Building 2, Manchester Royal Infirmary, Manchester M13 9WZ, United Kingdom"},{"name":"Statistics, Modeling and Economics Department, Centre for Infections, Health Protection Agency, Colindale, London NW9 5EQ, United Kingdom"},{"name":"Gloucester Vaccine Evaluation Unit, Health Protection Agency, Gloucestershire Royal Hospital, Gloucester, United Kingdom"},{"name":"Immunoassay Laboratory, Centre for Emergency Preparedness and Response, Health Protection Agency, Porton Down, Salisbury, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Miller","sequence":"additional","affiliation":[{"name":"Immunisation Department, Centre for Infections, Health Protection Agency, Colindale, London NW9 5EQ, United Kingdom"},{"name":"Vaccine Evaluation Unit, Health Protection Agency, Manchester Medical Microbiology Partnership, P.O. Box 209, Clinical Sciences Building 2, Manchester Royal Infirmary, Manchester M13 9WZ, United Kingdom"},{"name":"Statistics, Modeling and Economics Department, Centre for Infections, Health Protection Agency, Colindale, London NW9 5EQ, United Kingdom"},{"name":"Gloucester Vaccine Evaluation Unit, Health Protection Agency, Gloucestershire Royal Hospital, Gloucester, United Kingdom"},{"name":"Immunoassay Laboratory, Centre for Emergency Preparedness and Response, Health Protection Agency, Porton Down, Salisbury, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1128\/CDLI.10.5.780-786.2003","volume":"10","year":"2003","unstructured":"Andrews, N., R. Borrow, and E. Miller. 2003. Validation of serological correlate of protection for meningococcal C conjugate vaccine by using efficacy estimates from postlicensure surveillance in England. Clin. Diagn. Lab. 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Vaccine19:2924-2931.","journal-title":"Vaccine"},{"key":"e_1_3_2_8_2","unstructured":"Immunization against infectious disease\u2014the green book. 2006"},{"key":"e_1_3_2_9_2","unstructured":"Module 2: diphtheria. 1993"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000207483.60267.e7"},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1093\/infdis\/147.6.1100","volume":"147","year":"1983","unstructured":"Kayhty, H., H. Peltola, V. Karanko, and P. H. Makela. 1983. The protective level of serum antibodies to the capsular polysaccharide of Haemophilus influenzae type b. J. Infect. Dis.147:1100.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1136\/adc.2005.076109","volume":"92","year":"2007","unstructured":"Kitchin, N., J. Southern, R. Morris, F. Hemme, S. Thomas, M. Watson, K. Cartwright, and E. Miller. 2007. 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Vaccine20(Suppl. 1):S58-S67.","journal-title":"Vaccine"},{"key":"e_1_3_2_20_2","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/S0140-6736(97)06508-2","volume":"350","year":"1997","unstructured":"Olin, P., F. Rasmussen, L. Gustafsson, H. O. Hallander, H. Heijbel, et al. 1997. Randomised controlled trial of two-component, three-component, and five-component acellular pertussis vaccines compared with whole-cell pertussis vaccine. Lancet350:1569-1577.","journal-title":"Lancet"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(90)90264-V"},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1542\/peds.101.4.604","volume":"101","year":"1998","unstructured":"Rennels, M. B., K. M. Edwards, H. L. Keyserling, K. S. Reisinger, D. A. Hogerman, D. V. Madore, I. Chang, P. R. Paradiso, F. J. Malinoski, and A. Kimura. 1998. 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Immunogenicity of one, two or three doses of a meningococcal C conjugate vaccine conjugated to tetanus toxoid, given as a three-dose primary vaccination course in UK infants at 2, 3 and 4 months of age with acellular pertussis-containing DTP\/Hib vaccine. Vaccine24:215-219.","journal-title":"Vaccine"},{"key":"e_1_3_2_28_2","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1097\/01.inf.0000227725.61495.c4","volume":"25","year":"2006","unstructured":"Tejedor, J. C., M. Moro, J. Ruiz-Contreras, J. Castro, J. A. G\u00f3mez-Campder\u00e1, M. L. Navarro, J. M. Merino, A. Mart\u00edn-Ancel, J. Roca, M. Garc\u00eda-del-R\u00edo, A. Jurado, F. J. D\u00edez-Delgado, F. Ome\u00f1aca, J. Garc\u00eda-Sicilia, R. Boceta, P. Garc\u00eda-Corbeira, J. M. Jacquet, A. Collard, L. Schuerman, et al. 2006. Immunogenicity and reactogenicity of primary immunization with a hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated polio-Haemophilus influenzae type b vaccine coadministered with two doses of a meningococcal C-tetanus toxoid conjugate vaccine. Pediatr. Infect. Dis. J.25:713-720.","journal-title":"Pediatr. Infect. Dis. J."}],"container-title":["Clinical and Vaccine Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00420-08","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00420-08","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T11:54:50Z","timestamp":1627559690000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/CVI.00420-08"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["10.1128\/CVI.00420-08"],"URL":"https:\/\/doi.org\/10.1128\/cvi.00420-08","relation":{},"ISSN":["1556-6811","1556-679X"],"issn-type":[{"value":"1556-6811","type":"print"},{"value":"1556-679X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2]]},"assertion":[{"value":"2008-11-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-12-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}