{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:53:43Z","timestamp":1775804023907,"version":"3.50.1"},"reference-count":23,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>This study evaluated the safety, tolerability, and immunogenicity of an investigational quadrivalent meningococcal conjugate vaccine, MenACWY-CRM, when administered concomitantly with a combined tetanus, reduced diphtheria, and acellular pertussis (Tdap) vaccine, in subjects aged 11 to 25 years. Subjects received either MenACWY-CRM and Tdap, MenACWY-CRM and saline placebo, or Tdap and saline placebo. No significant increase in reactogenicity and no clinically significant vaccine-related adverse events (AEs) occurred when MenACWY-CRM and Tdap were administered concomitantly. Similar immunogenic responses to diphtheria, tetanus, and meningococcal (serogroups A, C, W-135, and Y) antigens were observed, regardless of concomitant vaccine administration. Antipertussis antibody responses were comparable between vaccine groups for filamentous hemagglutinin and were slightly lower, although not clinically significantly, for pertussis toxoid and pertactin when the two vaccines were administered concomitantly. These results indicate that the investigational MenACWY-CRM vaccine is well tolerated and immunogenic and that it can be coadministered with Tdap to adolescents and young adults.<\/jats:p>","DOI":"10.1128\/cvi.00436-09","type":"journal-article","created":{"date-parts":[[2010,2,18]],"date-time":"2010-02-18T02:32:38Z","timestamp":1266460358000},"page":"537-544","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":38,"title":["Randomized Trial on the Safety, Tolerability, and Immunogenicity of MenACWY-CRM, an Investigational Quadrivalent Meningococcal Glycoconjugate Vaccine, Administered Concomitantly with a Combined Tetanus, Reduced Diphtheria, and Acellular Pertussis Vaccine in Adolescents and Young Adults"],"prefix":"10.1128","volume":"17","author":[{"given":"Roberto","family":"Gasparini","sequence":"first","affiliation":[{"name":"Department of Health Sciences, University of Genoa, Genoa"},{"name":"Taranto Local Health Agency, Taranto"},{"name":"Pediatric Clinic, University of Novara, Novara"},{"name":"Department of Clinical and Experimental Medicine, University of Ferrara, Ferrara"},{"name":"Novartis Vaccines and Diagnostics Srl, Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Conversano","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of Genoa, Genoa"},{"name":"Taranto Local Health Agency, Taranto"},{"name":"Pediatric Clinic, University of Novara, Novara"},{"name":"Department of Clinical and Experimental Medicine, University of Ferrara, Ferrara"},{"name":"Novartis Vaccines and Diagnostics Srl, Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianni","family":"Bona","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of Genoa, Genoa"},{"name":"Taranto Local Health Agency, Taranto"},{"name":"Pediatric Clinic, University of Novara, Novara"},{"name":"Department of Clinical and Experimental Medicine, University of Ferrara, Ferrara"},{"name":"Novartis Vaccines and Diagnostics Srl, Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Gabutti","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of Genoa, Genoa"},{"name":"Taranto Local Health Agency, Taranto"},{"name":"Pediatric Clinic, University of Novara, Novara"},{"name":"Department of Clinical and Experimental Medicine, University of Ferrara, Ferrara"},{"name":"Novartis Vaccines and Diagnostics Srl, Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Anemona","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of Genoa, Genoa"},{"name":"Taranto Local Health Agency, Taranto"},{"name":"Pediatric Clinic, University of Novara, Novara"},{"name":"Department of Clinical and Experimental Medicine, University of Ferrara, Ferrara"},{"name":"Novartis Vaccines and Diagnostics Srl, Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M.","family":"Dull","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of Genoa, Genoa"},{"name":"Taranto Local Health Agency, Taranto"},{"name":"Pediatric Clinic, University of Novara, Novara"},{"name":"Department of Clinical and Experimental Medicine, University of Ferrara, Ferrara"},{"name":"Novartis Vaccines and Diagnostics Srl, Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Ceddia","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of Genoa, Genoa"},{"name":"Taranto Local Health Agency, Taranto"},{"name":"Pediatric Clinic, University of Novara, Novara"},{"name":"Department of Clinical and Experimental Medicine, University of Ferrara, Ferrara"},{"name":"Novartis Vaccines and Diagnostics Srl, Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1542\/peds.2005-1314","volume":"116","year":"2005","unstructured":"American Academy of Pediatrics Committee on Infectious Diseases. 2005. 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