{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:52:57Z","timestamp":1789951977442,"version":"4.0.1"},"reference-count":51,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content content-type=\"genus-species\">Shigella<\/jats:named-content>\n            spp. represent the second most common etiologic pathogen causing childhood diarrhea in developing countries. There are no licensed\n            <jats:named-content content-type=\"genus-species\">Shigella<\/jats:named-content>\n            vaccines, and progress for such vaccines has been limited. In this issue of\n            <jats:italic>Clinical and Vaccine Immunology<\/jats:italic>\n            , Riddle and colleagues (M. S. Riddle, R. W. Kaminski, C. Di Paolo, C. K. Porter, R. L. Gutierrez, et al., Clin Vaccine Immunol 23:908\u2013917, 2016,\n            <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1128\/CVI.00224-16\">http:\/\/dx.doi.org\/10.1128\/CVI.00224-16<\/jats:ext-link>\n            ) report results from a phase I study of a parenterally administered monovalent O-polysaccharide \u201cbioconjugate\u201d directed against\n            <jats:named-content content-type=\"genus-species\">Shigella flexneri<\/jats:named-content>\n            2a. Ultimately, the goal is to develop a broad-spectrum\n            <jats:named-content content-type=\"genus-species\">Shigella<\/jats:named-content>\n            vaccine to address this public health concern. A parenteral\n            <jats:named-content content-type=\"genus-species\">Shigella<\/jats:named-content>\n            vaccine capable of eliciting protection in children of developing countries would be an important tool to reach this goal.\n          <\/jats:p>","DOI":"10.1128\/cvi.00444-16","type":"journal-article","created":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T02:59:19Z","timestamp":1475722759000},"page":"904-907","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Shigella Vaccine Development: Finding the Path of Least Resistance"],"prefix":"10.1128","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7741-5536","authenticated-orcid":false,"given":"Wilbur H.","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA"},{"name":"Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L.","family":"Kotloff","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA"},{"name":"Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA"},{"name":"Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61698-6"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.11.035"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60844-2"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(15)00151-5"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.14-0319"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6737(16)31529-X"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002055"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.12"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1662"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0264-410X(90)90094-3"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0264-410X(94)00011-B"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/157.5.1068"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1093\/oxfordjournals.aje.a116134","article-title":"Epidemiologic patterns of acute diarrhea and endemic Shigella infections in children in a poor periurban setting in Santiago, Chile","volume":"134","author":"Ferreccio C","year":"1991","unstructured":"Ferreccio C, Prado V, Ojeda A, Cayyazo M, Abrego P, Guers L, Levine MM. 1991. 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