{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T07:16:45Z","timestamp":1790320605493,"version":"4.1.0"},"reference-count":34,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Pertussis is a highly contagious respiratory illness caused by the bacterial pathogen\n                    <jats:named-content content-type=\"genus-species\">Bordetella pertussis<\/jats:named-content>\n                    . Pertussis rates in the United States have escalated since the 1990s and reached a 50-year high of 48,000 cases in 2012. While this pertussis resurgence is not completely understood, we previously showed that the current acellular pertussis vaccines do not prevent colonization or transmission following challenge. In contrast, a whole-cell pertussis vaccine accelerated the rate of clearance compared to rates in unvaccinated animals and animals treated with the acellular vaccine. In order to understand if these results are generalizable, we used our baboon model to compare immunity from whole-cell vaccines from three different manufacturers that are approved outside the United States. We found that, compared to clearance rates with no vaccine and with an acellular pertussis vaccine, immunization with any of the three whole-cell vaccines significantly accelerated the clearance of\n                    <jats:named-content content-type=\"genus-species\">B. pertussis<\/jats:named-content>\n                    following challenge. Whole-cell vaccination also significantly reduced the total nasopharyngeal\n                    <jats:named-content content-type=\"genus-species\">B. pertussis<\/jats:named-content>\n                    burden, suggesting that these vaccines reduce the opportunity for pertussis transmission. Meanwhile, there was no difference in either the duration or in\n                    <jats:named-content content-type=\"genus-species\">B. pertussis<\/jats:named-content>\n                    burden between unvaccinated and acellular-pertussis-vaccinated animals, while previously infected animals were not colonized following reinfection. We also determined that transcription of the gene encoding interleukin-17 (IL-17) was increased in whole-cell-vaccinated and previously infected animals but not in acellular-pertussis-vaccinated animals following challenge. Together with our previous findings, these data are consistent with a role for Th17 responses in the clearance of\n                    <jats:named-content content-type=\"genus-species\">B. pertussis<\/jats:named-content>\n                    infection.\n                  <\/jats:p>","DOI":"10.1128\/cvi.00449-15","type":"journal-article","created":{"date-parts":[[2015,11,11]],"date-time":"2015-11-11T21:29:10Z","timestamp":1447277350000},"page":"47-54","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":60,"title":["Comparison of Three Whole-Cell Pertussis Vaccines in the Baboon Model of Pertussis"],"prefix":"10.1128","volume":"23","author":[{"given":"Jason M.","family":"Warfel","sequence":"first","affiliation":[{"name":"Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, FDA, Silver Spring, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey I.","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, FDA, Silver Spring, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tod J.","family":"Merkel","sequence":"additional","affiliation":[{"name":"Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, FDA, Silver Spring, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3235"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu001"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1586\/erv.12.118"},{"key":"e_1_3_2_5_2","unstructured":"Centers for Disease Control and Prevention. 2014. Pertussis (whooping cough): surveillance and reporting. Centers for Disease Control and Prevention Atlanta GA. http:\/\/www.cdc.gov\/pertussis\/surv-reporting.html. Accessed 23 June 2015."},{"key":"e_1_3_2_6_2","unstructured":"Centers for Disease Control and Prevention. 2014. Vaccination coverage in the United States. Centers for Disease Control and Prevention Atlanta GA. http:\/\/www.cdc.gov\/vaccines\/imz-managers\/coverage\/imz-coverage.html. Accessed 23 February 2015."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu788"},{"key":"e_1_3_2_8_2","first-page":"669","article-title":"Notifiable diseases and mortality tables","volume":"62","author":"CDC","year":"2013","unstructured":"CDC. 2013. Notifiable diseases and mortality tables. MMWR Morb Mortal Wkly Rep 62:669\u2013682.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_3_2_9_2","unstructured":"Australian Government Department of Health. 2014. National notifiable diseases surveillance system. Australian Government Department of Health Canberra Australia. http:\/\/www9.health.gov.au\/cda\/source\/cda-index.cfm. Accessed 23 June 2015."},{"key":"e_1_3_2_10_2","unstructured":"Public Health England. 2014. Laboratory confirmed cases of pertussis infection by laboratory method year and quarter England: 2002\u20132013. Public Health England London England. http:\/\/www.hpa.org.uk\/webc\/HPAwebFile\/HPAweb_C\/1317133571358. Accessed 23 June 2015."},{"key":"e_1_3_2_11_2","unstructured":"World Health Organization. 2014. SAGE pertussis working group background paper. World Health Organization Geneva Switzerland. www.who.int\/entity\/immunization\/sage\/meetings\/2014\/april\/1_Pertussis_background_FINAL4_web.pdf?ua=1. Accessed 19 June 2015."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit046"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1212006"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.6364"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-3836"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.2014.944167"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit592"},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1056\/NEJM199602083340601","article-title":"A controlled trial of two acellular vaccines and one whole-cell vaccine against pertussis. Progetto Pertosse Working Group","volume":"334","author":"Greco D","year":"1996","unstructured":"Greco D, Salmaso S, Mastrantonio P, Giuliano M, Tozzi AE, Anemona A, Ciofi degli Atti ML, Giammanco A, Panei P, Blackwelder WC, Klein DL, Wassilak SG. 1996. A controlled trial of two acellular vaccines and one whole-cell vaccine against pertussis. Progetto Pertosse Working Group. N Engl J Med 334:341\u2013348.","journal-title":"N Engl J Med"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199602083340602"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.101.1.1"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(97)00100-X"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199711000-00007"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03530250041024"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1314688110"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2012.117"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.06310-11"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis443"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.00657-15"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.2014.946016"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-015-0382-8"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2010.11.002"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00277-12"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00270-13"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit531"}],"container-title":["Clinical and Vaccine Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00449-15","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00449-15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T11:56:29Z","timestamp":1627559789000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/CVI.00449-15"}},"subtitle":[],"editor":[{"given":"D. W.","family":"Pascual","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1128\/CVI.00449-15"],"URL":"https:\/\/doi.org\/10.1128\/cvi.00449-15","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725953914.793535742","asserted-by":"object"}]},"ISSN":["1556-6811","1556-679X"],"issn-type":[{"value":"1556-6811","type":"print"},{"value":"1556-679X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"2015-08-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-11-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-01-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}