{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T06:02:32Z","timestamp":1791007352652,"version":"4.1.0"},"reference-count":53,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Recently, molecular screening for pathogenic agents has identified a partial genome of a novel parvovirus, called human bocavirus (HBoV). The presence of this newly described parvovirus correlated with upper and lower respiratory tract infections in children. Lower respiratory tract infections are a leading cause of hospital admission in children, and the etiological agent has not been identified in up to 39% of these cases. Using baculovirus expression vectors (BEVs) and an insect cell system, we produced virus-like particles (VLPs) of HBoV. The engineered BEVs express the HBoV capsid proteins stoichiometrically from a single open reading frame. Three capsid proteins assemble into the VLP rather than two proteins predicted from the HBoV genome sequence. The denatured capsid proteins VP1, VP2, and VP3 resolve on silver-stained sodium dodecyl sulfate-polyacrylamide gels as three bands with apparent molecular masses of 72 kDa, 68 kDa, and 62 kDa, respectively. VP2 apparently initiates at a GCT codon (alanine) 273 nucleotides downstream from the VP1 start site and 114 nucleotides upstream from the VP3 initiation site. We characterized the stable capsids using physical, biochemical, and serological techniques. We found that the density of the VLP is 1.32 g\/cm\n            <jats:sup>3<\/jats:sup>\n            and is consistent with an icosahedral symmetry with approximately a 25-nm diameter. Rabbit antiserum against the capsid of HBoV, which did not cross-react with adeno-associated virus type 2, was used to develop enzyme-linked immunosorbent assays (ELISAs) for anti-HBoV antibodies in human serum. Using ELISA, we tested 404 human serum samples and established a range of antibody titers in a large U.S. adult population sample.\n          <\/jats:p>","DOI":"10.1128\/cvi.00470-08","type":"journal-article","created":{"date-parts":[[2009,2,26]],"date-time":"2009-02-26T02:43:18Z","timestamp":1235616198000},"page":"597-604","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["Evidence of Prior Exposure to Human Bocavirus as Determined by a Retrospective Serological Study of 404 Serum Samples from Adults in the United States"],"prefix":"10.1128","volume":"16","author":[{"given":"Sylvain","family":"Cecchini","sequence":"first","affiliation":[{"name":"Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland"},{"name":"Viral Pathogenesis Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland"},{"name":"Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Negrete","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland"},{"name":"Viral Pathogenesis Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland"},{"name":"Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamas","family":"Virag","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland"},{"name":"Viral Pathogenesis Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland"},{"name":"Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barney S.","family":"Graham","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland"},{"name":"Viral Pathogenesis Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland"},{"name":"Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey I.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland"},{"name":"Viral Pathogenesis Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland"},{"name":"Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Kotin","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland"},{"name":"Viral Pathogenesis Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland"},{"name":"Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","unstructured":"Handbook of mathematical functions with formulas graphs and mathematical tables. 1965"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"12891","DOI":"10.1073\/pnas.0504666102","volume":"102","year":"2005","unstructured":"Allander, T., M. T. Tammi, M. Eriksson, A. Bjerkner, A. Tiveljung-Lindell, and B. Andersson. 2005. Cloning of a human parvovirus by molecular screening of respiratory tract samples. Proc. Natl. Acad. Sci. USA102:12891-12896.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1097\/00006454-198708000-00003","volume":"6","year":"1987","unstructured":"Anderson, L. J. 1987. Role of parvovirus B19 in human disease. Pediatr. Infect. Dis. J.6:711-718.","journal-title":"Pediatr. Infect. Dis. J."},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1002\/jmv.20689","volume":"78","year":"2006","unstructured":"Arden, K. E., P. McErlean, M. D. Nissen, T. P. Sloots, and I. M. Mackay. 2006. Frequent detection of human rhinoviruses, paramyxoviruses, coronaviruses, and bocavirus during acute respiratory tract infections. J. Med. Virol.78:1232-1240.","journal-title":"J. Med. Virol."},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1086\/505399","volume":"43","year":"2006","unstructured":"Arnold, J. C., K. K. Singh, S. A. Spector, and M. H. Sawyer. 2006. Human bocavirus: prevalence and clinical spectrum at a children's hospital. Clin. Infect. Dis.43:283-288.","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01044-06"},{"key":"e_1_3_2_8_2","first-page":"279","volume":"3","year":"1994","unstructured":"Bloom, M. E., H. Kanno, S. Mori, and J. B. Wolfinbarger. 1994. Aleutian mink disease: puzzles and paradigms. Infect. Agents Dis.3:279-301.","journal-title":"Infect. Agents Dis."},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1097\/INF.0b013e31816be052","volume":"27","year":"2008","unstructured":"Calvo, C., M. L. Garcia-Garcia, F. Pozo, O. Carvajal, P. Perez-Brena, and I. Casas. 2008. Clinical characteristics of human bocavirus infections compared with other respiratory viruses in Spanish children. Pediatr. Infect. Dis. J.27:677-680.","journal-title":"Pediatr. Infect. Dis. J."},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1006\/jmbi.2001.4896","volume":"311","year":"2001","unstructured":"Canady, M. A., H. Tsuruta, and J. E. Johnson. 2001. Analysis of rapid, large-scale protein quaternary structural changes: time-resolved X-ray solution scattering of Nudaurelia capensis omega virus (NomegaV) maturation. J. Mol. Biol.311:803-814.","journal-title":"J. Mol. Biol."},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1002\/jmv.21108","volume":"80","year":"2008","unstructured":"Canducci, F., M. Debiaggi, M. Sampaolo, M. C. Marinozzi, S. Berre, C. Terulla, G. Gargantini, P. Cambieri, E. Romero, and M. Clementi. 2008. Two-year prospective study of single infections and co-infections by respiratory syncytial virus and viruses identified recently in infants with acute respiratory disease. J. Med. Virol.80:716-723.","journal-title":"J. Med. Virol."},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/mt.2008.35","volume":"16","year":"2008","unstructured":"Chen, H. 2008. Intron splicing-mediated expression of AAV Rep. and Cap genes and production of AAV vectors in insect cells. Mol. Ther.16:924-930.","journal-title":"Mol. Ther."},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1086\/506350","volume":"43","year":"2006","unstructured":"Choi, E. H., H. J. Lee, S. J. Kim, B. W. Eun, N. H. Kim, J. A. Lee, J. H. Lee, E. K. Song, S. H. Kim, J. Y. Park, and J. Y. Sung. 2006. The association of newly identified respiratory viruses with lower respiratory tract infections in Korean children, 2000-2005. Clin. Infect. Dis.43:585-592.","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jcv.2008.02.010","volume":"42","year":"2008","unstructured":"Choi, J. H., Y. S. Chung, K. S. Kim, W. J. Lee, I. Y. Chung, H. B. Oh, and C. Kang. 2008. Development of real-time PCR assays for detection and quantification of human bocavirus. J. Clin. Virol.42:249-253.","journal-title":"J. Clin. Virol."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02140-06"},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2307\/2340521","volume":"85","year":"1922","unstructured":"Fisher, R. A. 1922. On the interpretation of \u03c72 from contingency tables, and the calculation of P. J. R. Stat. Soc.85:87-94.","journal-title":"Stat. Soc."},{"key":"e_1_3_2_17_2","first-page":"1876","volume":"57","year":"2007","unstructured":"Freymuth, F., A. Vabret, J. Dina, J. Petitjean, and S. Gouarin. 2007. Techniques used for the diagnostic of upper and lower respiratory tract viral infections. Rev. Prat.57:1876-1882. (In French.)","journal-title":"Rev. Prat."},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1086\/512163","volume":"195","year":"2007","unstructured":"Fry, A. M., X. Lu, M. Chittaganpitch, T. Peret, J. Fischer, S. F. Dowell, L. J. Anderson, D. Erdman, and S. J. Olsen. 2007. Human bocavirus: a novel parvovirus epidemiologically associated with pneumonia requiring hospitalization in Thailand. J. Infect. Dis.195:1038-1045.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_19_2","first-page":"571","year":"2005","unstructured":"Gasteiger, E., C. Hoogland, A. Gattiker, S. Duvaud, M. R. Wilkins, R. D. Appel, and A. Bairoch. 2005. Protein identification and analysis tools on the ExPASy server, p. 571-607. In J. M. Walker (ed.), The proteomics protocols handbook. Humana Press, Totowa, NJ.","journal-title":"The proteomics protocols handbook."},{"key":"e_1_3_2_20_2","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1099\/0022-1317-83-5-973","volume":"83","year":"2002","unstructured":"Girod, A., C. E. Wobus, Z. Zadori, M. Ried, K. Leike, P. Tijssen, J. A. Kleinschmidt, and M. Hallek. 2002. The VP1 capsid protein of adeno-associated virus type 2 is carrying a phospholipase A2 domain required for virus infectivity. J. Gen. Virol.83:973-978.","journal-title":"J. Gen. Virol."},{"key":"e_1_3_2_21_2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.virusres.2008.01.012","volume":"133","year":"2008","unstructured":"Halsey, R. J., F. L. Tanzer, A. Meyers, S. Pillay, A. Lynch, E. Shephard, A. L. Williamson, and E. P. Rybicki. 2008. Chimaeric HIV-1 subtype C Gag molecules with large in-frame C-terminal polypeptide fusions form virus-like particles. Virus Res.133:259-268.","journal-title":"Virus Res."},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1073\/pnas.55.6.1467","volume":"55","year":"1966","unstructured":"Hoggan, M. D., N. R. Blacklow, and W. P. Rowe. 1966. Studies of small DNA viruses found in various adenovirus preparations: physical, biological, and immunological characteristics. Proc. Natl. Acad. Sci. USA55:1467-1474.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_2_23_2","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jcv.2008.05.010","volume":"43","year":"2008","unstructured":"Jacques, J., H. Moret, F. Renois, N. Leveque, J. Motte, and L. Andreoletti. 2008. Human bocavirus quantitative DNA detection in French children hospitalized for acute bronchiolitis. J. Clin. Virol.43:142-147.","journal-title":"J. Clin. Virol."},{"key":"e_1_3_2_24_2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1086\/588674","volume":"198","year":"2008","unstructured":"Kahn, J. S., D. Kesebir, S. F. Cotmore, A. D'Abramo, Jr., C. Cosby, C. Weibel, and P. Tattersall. 2008. Seroepidemiology of human bocavirus defined using recombinant virus-like particles. J. Infect. Dis.198:41-50.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_25_2","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1086\/508213","volume":"194","year":"2006","unstructured":"Kesebir, D., M. Vazquez, C. Weibel, E. D. Shapiro, D. Ferguson, M. L. Landry, and J. S. Kahn. 2006. Human bocavirus infection in young children in the United States: molecular epidemiological profile and clinical characteristics of a newly emerging respiratory virus. J. Infect. Dis.194:1276-1282.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1093\/embo-reports\/kve234","volume":"2","year":"2001","unstructured":"Kronenberg, S., J. A. Kleinschmidt, and B. Bottcher. 2001. Electron cryo-microscopy and image reconstruction of adeno-associated virus type 2 empty capsids. EMBO Rep.2:997-1002.","journal-title":"EMBO Rep."},{"key":"e_1_3_2_27_2","first-page":"619","volume":"44","year":"1987","unstructured":"Lacaze, T., Y. de Prost, J. J. Lefrere, and A. M. Courouce. 1987. Parvovirus B19 and the fifth disease. Arch. Fr. Pediatr.44:619-620. (In French.)","journal-title":"Arch. Fr. Pediatr."},{"key":"e_1_3_2_28_2","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1086\/521310","volume":"196","year":"2007","unstructured":"Lau, S. K., C. C. Yip, T. L. Que, R. A. Lee, R. K. Au-Yeung, B. Zhou, L. Y. So, Y. L. Lau, K. H. Chan, P. C. Woo, and K. Y. Yuen. 2007. Clinical and molecular epidemiology of human bocavirus in respiratory and fecal samples from children in Hong Kong. J. Infect. Dis.196:986-993.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_29_2","first-page":"211","volume":"20","year":"2008","unstructured":"Liao, S., S. Wang, L. Xu, D. Deng, Q. Xu, W. Wang, T. Zhu, X. Bai, J. Zhou, G. Xu, Y. Lu, L. Meng, and D. Ma. 2008. Production and verification of human papillomavirus type 18 vaccine in vitro. Oncol. Rep.20:211-217.","journal-title":"Oncol. Rep."},{"key":"e_1_3_2_30_2","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jviromet.2007.12.016","volume":"149","year":"2008","unstructured":"Lin, F., W. Guan, F. Cheng, N. Yang, D. Pintel, and J. Qiu. 2008. ELISAs using human bocavirus VP2 virus-like particles for detection of antibodies against HBoV. J. Virol. Methods149:110-117.","journal-title":"J. Virol. Methods"},{"key":"e_1_3_2_31_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1750-9378-2-3","volume":"2","year":"2007","unstructured":"Lin, F., A. Zeng, N. Yang, H. Lin, E. Yang, S. Wang, D. Pintel, and J. Qiu. 2007. Quantification of human bocavirus in lower respiratory tract infections in China. Infect. Agents Cancer2:3.","journal-title":"Infect. Agents Cancer"},{"key":"e_1_3_2_32_2","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1089\/vim.2008.0045","volume":"21","year":"2008","unstructured":"Lindner, J., L. Karalar, S. Zehentmeier, A. Plentz, H. Pfister, W. Struff, M. Kertai, H. Segerer, and S. Modrow. 2008. Humoral immune response against human bocavirus VP2 virus-like particles. Viral Immunol.21:443-449.","journal-title":"Viral Immunol."},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00889-06"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.3.1132-1134.2006"},{"key":"e_1_3_2_35_2","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1086\/521311","volume":"196","year":"2007","unstructured":"Mackay, I. M. 2007. Human bocavirus: multisystem detection raises questions about infection. J. Infect. Dis.196:968-970.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_36_2","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1086\/508219","volume":"194","year":"2006","unstructured":"Manning, A., V. Russell, K. Eastick, G. H. Leadbetter, N. Hallam, K. Templeton, and P. Simmonds. 2006. Epidemiological profile and clinical associations of human bocavirus and other human parvoviruses. J. Infect. Dis.194:1283-1290.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_37_2","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/jmv.20815","volume":"79","year":"2007","unstructured":"Naghipour, M., L. E. Cuevas, T. Bakhshinejad, W. Dove, and C. A. Hart. 2007. Human bocavirus in Iranian children with acute respiratory infections. J. Med. Virol.79:539-543.","journal-title":"J. Med. Virol."},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00027-07"},{"key":"e_1_3_2_39_2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0950-3536(05)80232-X","volume":"8","year":"1995","unstructured":"Parrish, C. R. 1995. Pathogenesis of feline panleukopenia virus and canine parvovirus. Bailli\u00e8res Clin. Haematol.8:57-71.","journal-title":"Bailli\u00e8res Clin. Haematol."},{"key":"e_1_3_2_40_2","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0195-5616(93)50305-4","volume":"23","year":"1993","unstructured":"Pollock, R. V., and M. J. Coyne. 1993. Canine parvovirus. Vet. Clin. N. Am. Small Anim. Pract.23:555-568.","journal-title":"Vet. Clin. N. Am. Small Anim. Pract."},{"key":"e_1_3_2_41_2","first-page":"447","volume":"23","year":"2007","unstructured":"Qi, Z. Y., X. W. Qu, W. P. Liu, Z. P. Xie, H. C. Gao, L. S. Zheng, Z. Z. Kuang, J. P. Yu, and Z. J. Duan. 2007. Genome cloning and phylogenetic analysis of human bocavirus capsid gene. Bing Du Xue Bao23:447-453. (In Chinese.)","journal-title":"Bing Du Xue Bao"},{"key":"e_1_3_2_42_2","first-page":"165","volume":"13","year":"2007","unstructured":"Qu, X. W., Z. J. Duan, Z. Y. Qi, Z. P. Xie, H. C. Gao, W. P. Liu, C. P. Huang, F. W. Peng, L. S. Zheng, and Y. D. Hou. 2007. Human bocavirus infection, People's Republic of China. Emerg. Infect. Dis.13:165-168.","journal-title":"Emerg. Infect. Dis."},{"key":"e_1_3_2_43_2","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1099\/0022-1317-75-8-2075","volume":"75","year":"1994","unstructured":"Rose, R. C., R. C. Reichman, and W. Bonnez. 1994. Human papillomavirus (HPV) type 11 recombinant virus-like particles induce the formation of neutralizing antibodies and detect HPV-specific antibodies in human sera. J. Gen. Virol.75:2075-2079.","journal-title":"J. Gen. Virol."},{"key":"e_1_3_2_44_2","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1089\/hum.2006.17.487","volume":"17","year":"2006","unstructured":"Ross, C. J., J. Twisk, A. C. Bakker, F. Miao, D. Verbart, J. Rip, T. Godbey, P. Dijkhuizen, W. T. Hermens, J. J. Kastelein, J. A. Kuivenhoven, J. M. Meulenberg, and M. R. Hayden. 2006. Correction of feline lipoprotein lipase deficiency with adeno-associated virus serotype 1-mediated gene transfer of the lipoprotein lipase S447X beneficial mutation. Hum. Gene Ther.17:487-499.","journal-title":"Hum. Gene Ther."},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.66.12.6922-6930.1992"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00030-07"},{"key":"e_1_3_2_47_2","first-page":"165","volume":"60","year":"1970","unstructured":"Scott, F. W., C. K. Csiza, and J. H. Gillespie. 1970. Feline viruses. IV. Isolation and characterization of feline panleukopenia virus in tissue culture and comparison of cytopathogenicity with feline picornavirus, herpesvirus, and reovirus. Cornell Vet.60:165-182.","journal-title":"Cornell Vet."},{"key":"e_1_3_2_48_2","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1161\/ATVBAHA.108.175620","volume":"28","year":"2008","unstructured":"Stroes, E. S., M. C. Nierman, J. J. Meulenberg, R. Franssen, J. Twisk, C. P. Henny, M. M. Maas, A. H. Zwinderman, C. Ross, E. Aronica, K. A. High, M. M. Levi, M. R. Hayden, J. J. Kastelein, and J. A. Kuivenhoven. 2008. Intramuscular administration of AAV1-lipoprotein lipase S447X lowers triglycerides in lipoprotein lipase-deficient patients. Arterioscler. Thromb. Vasc. Biol.28:2303-2304.","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"e_1_3_2_49_2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00705-005-0637-3","volume":"151","year":"2006","unstructured":"Taylor, D. J., J. A. Speir, V. Reddy, G. Cingolani, F. M. Pringle, L. A. Ball, and J. E. Johnson. 2006. Preliminary X-ray characterization of authentic providence virus and attempts to express its coat protein gene in recombinant baculovirus. Arch. Virol.151:155-165.","journal-title":"Arch. Virol."},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.62.9.3356-3363.1988"},{"key":"e_1_3_2_51_2","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1089\/10430340260355347","volume":"13","year":"2002","unstructured":"Urabe, M., C. Ding, and R. M. Kotin. 2002. Insect cells as a factory to produce adeno-associated virus type 2 vectors. Hum. Gene Ther.13:1935-1943.","journal-title":"Hum. Gene Ther."},{"key":"e_1_3_2_52_2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/1471-2334-6-109","volume":"6","year":"2006","unstructured":"Weissbrich, B., F. Neske, J. Schubert, F. Tollmann, K. Blath, K. Blessing, and H. W. Kreth. 2006. Frequent detection of bocavirus DNA in German children with respiratory tract infections. BMC Infect. Dis.6:109.","journal-title":"BMC Infect. Dis."},{"key":"e_1_3_2_53_2","first-page":"159","volume":"25","year":"1988","unstructured":"Young, N. 1988. Hematologic and hematopoietic consequences of B19 parvovirus infection. Semin. Hematol.25:159-172.","journal-title":"Semin. Hematol."},{"key":"e_1_3_2_54_2","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S1534-5807(01)00031-4","volume":"1","year":"2001","unstructured":"Zadori, Z., J. Szelei, M. C. Lacoste, Y. Li, S. Gariepy, P. Raymond, M. Allaire, I. R. Nabi, and P. Tijssen. 2001. A viral phospholipase A2 is required for parvovirus infectivity. Dev. Cell1:291-302.","journal-title":"Dev. Cell"}],"container-title":["Clinical and Vaccine Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00470-08","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00470-08","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T15:55:08Z","timestamp":1627574108000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/CVI.00470-08"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":53,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["10.1128\/CVI.00470-08"],"URL":"https:\/\/doi.org\/10.1128\/cvi.00470-08","relation":{},"ISSN":["1556-6811","1556-679X"],"issn-type":[{"value":"1556-6811","type":"print"},{"value":"1556-679X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5]]},"assertion":[{"value":"2008-12-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-02-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}