{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:06:10Z","timestamp":1761843970570},"reference-count":39,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The immunodominance of\n            <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n            proteins malate synthase (MS) and MPT51 has been demonstrated in case-control studies with patients from countries in which tuberculosis (TB) is endemic. The value of these antigens for the serodiagnosis of TB now is evaluated in a cross-sectional study of pulmonary TB suspects in the United States diagnosed to have TB, HIV-associated TB, or other respiratory diseases (ORD). Serum antibody reactivity to recombinant purified MS and MPT51 was determined by enzyme-linked immunosorbent assays (ELISAs) of samples from TB suspects and well-characterized control groups. TB suspects were diagnosed with TB (\n            <jats:italic>n<\/jats:italic>\n            = 87; 49% sputum microscopy negative, 20% HIV\n            <jats:sup>+<\/jats:sup>\n            ) or ORD (\n            <jats:italic>n<\/jats:italic>\n            = 63; 58% HIV\n            <jats:sup>+<\/jats:sup>\n            ). Antibody reactivity to MS and MPT51 was significantly higher in U.S. HIV\n            <jats:sup>+<\/jats:sup>\n            \/TB samples than in HIV\n            <jats:sup>\u2212<\/jats:sup>\n            \/TB samples (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001), and it was significantly higher in both TB groups than in control groups with latent TB infection (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001). Antibody reactivity to both antigens was higher in U.S. HIV\n            <jats:sup>+<\/jats:sup>\n            \/TB samples than in HIV\n            <jats:sup>+<\/jats:sup>\n            \/ORD samples (\n            <jats:italic>P<\/jats:italic>\n            = 0.052 for MS,\n            <jats:italic>P<\/jats:italic>\n            = 0.001 for MPT51) but not significantly different between HIV\n            <jats:sup>\u2212<\/jats:sup>\n            \/TB and HIV\n            <jats:sup>\u2212<\/jats:sup>\n            \/ORD. Among U.S. HIV\n            <jats:sup>+<\/jats:sup>\n            TB suspects, a positive anti-MPT51 antibody response was strongly and significantly associated with TB (odds ratio, 11.0; 95% confidence interval, 2.3 to 51.2;\n            <jats:italic>P<\/jats:italic>\n            = 0.002). These findings have implications for the adjunctive use of TB serodiagnosis with these antigens in HIV\n            <jats:sup>+<\/jats:sup>\n            subjects.\n          <\/jats:p>","DOI":"10.1128\/cvi.00503-09","type":"journal-article","created":{"date-parts":[[2010,1,14]],"date-time":"2010-01-14T02:45:39Z","timestamp":1263437139000},"page":"384-392","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":33,"title":["Antibodies against Immunodominant Antigens of\n            <i>Mycobacterium tuberculosis<\/i>\n            in Subjects with Suspected Tuberculosis in the United States Compared by HIV Status"],"prefix":"10.1128","volume":"17","author":[{"given":"Jacqueline M.","family":"Achkar","sequence":"first","affiliation":[{"name":"Departments of Medicine"},{"name":"Biochemistry"},{"name":"Microbiology &amp; Immunology, Albert Einstein College of Medicine, Bronx, New York"},{"name":"Departments of Medicine"},{"name":"Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Jenny-Avital","sequence":"additional","affiliation":[{"name":"Departments of Medicine"},{"name":"Biochemistry"},{"name":"Microbiology &amp; Immunology, Albert Einstein College of Medicine, Bronx, New York"},{"name":"Departments of Medicine"},{"name":"Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian","family":"Yu","sequence":"additional","affiliation":[{"name":"Departments of Medicine"},{"name":"Biochemistry"},{"name":"Microbiology &amp; Immunology, Albert Einstein College of Medicine, Bronx, New York"},{"name":"Departments of Medicine"},{"name":"Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Burger","sequence":"additional","affiliation":[{"name":"Departments of Medicine"},{"name":"Biochemistry"},{"name":"Microbiology &amp; Immunology, Albert Einstein College of Medicine, Bronx, New York"},{"name":"Departments of Medicine"},{"name":"Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Leibert","sequence":"additional","affiliation":[{"name":"Departments of Medicine"},{"name":"Biochemistry"},{"name":"Microbiology &amp; Immunology, Albert Einstein College of Medicine, Bronx, New York"},{"name":"Departments of Medicine"},{"name":"Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick W.","family":"Bilder","sequence":"additional","affiliation":[{"name":"Departments of Medicine"},{"name":"Biochemistry"},{"name":"Microbiology &amp; Immunology, Albert Einstein College of Medicine, Bronx, New York"},{"name":"Departments of Medicine"},{"name":"Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven C.","family":"Almo","sequence":"additional","affiliation":[{"name":"Departments of Medicine"},{"name":"Biochemistry"},{"name":"Microbiology &amp; Immunology, Albert Einstein College of Medicine, Bronx, New York"},{"name":"Departments of Medicine"},{"name":"Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arturo","family":"Casadevall","sequence":"additional","affiliation":[{"name":"Departments of Medicine"},{"name":"Biochemistry"},{"name":"Microbiology &amp; Immunology, Albert Einstein College of Medicine, Bronx, New York"},{"name":"Departments of Medicine"},{"name":"Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suman","family":"Laal","sequence":"additional","affiliation":[{"name":"Departments of Medicine"},{"name":"Biochemistry"},{"name":"Microbiology &amp; Immunology, Albert Einstein College of Medicine, Bronx, New York"},{"name":"Departments of Medicine"},{"name":"Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00158-06"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1080\/00365540701402954","volume":"39","year":"2007","unstructured":"Bethunaickan, R., A. R. Baulard, C. Locht, and A. Raja. 2007. Antibody response in pulmonary tuberculosis against recombinant 27kDa (MPT51, Rv3803c) protein of Mycobacterium tuberculosis. Scand. J. Infect. Dis.39:867-874.","journal-title":"Scand. J. Infect. Dis."},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1465-9921-7-56","volume":"7","year":"2006","unstructured":"Brock, I., M. Ruhwald, B. Lundgren, H. Westh, L. R. Mathiesen, and P. Ravn. 2006. Latent tuberculosis in HIV positive, diagnosed by the M-tuberculosis specific interferon-gamma test. Resp. Res.7:56.","journal-title":"Resp. Res."},{"key":"e_1_3_2_5_2","first-page":"1","volume":"39","year":"1990","unstructured":"Centers for Disease Control and Prevention. 1990. Screening for tuberculosis and tuberculous infection in high-risk populations. Recommendations of the Advisory Committee for Elimination of Tuberculosis. MMWR Recomm. Rep.39:1-7.","journal-title":"MMWR Recomm. Rep."},{"key":"e_1_3_2_6_2","unstructured":"Reported tuberculosis in the United States 2006. 2007"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1164\/rccm.200405-590OC","volume":"170","year":"2004","unstructured":"Corbett, E. L., S. Charalambous, V. M. Moloi, K. Fielding, A. D. Grant, C. Dye, K. M. De Cock, R. J. Hayes, B. G. Williams, and G. J. Churchyard. 2004. Human immunodeficiency virus and the prevalence of undiagnosed tuberculosis in African gold miners. Am. J. Resp. Crit. Care Med.170:673-679.","journal-title":"Am. J. Resp. Crit. Care Med."},{"key":"e_1_3_2_8_2","first-page":"624","volume":"11","year":"2007","unstructured":"Gennaro, M. L., M. Affouf, G. V. Kanaujia, P. N. Brusasca, B. Mangura, and L. Reichman. 2007. Antibody markers of incident tuberculosis among HIV\u2212infected adults in the U.S.A.: a historical prospective study. Int. J. Tuber. Lung Dis.11:624-631.","journal-title":"Int. J. Tuber. Lung Dis."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.6.2354-2361.2000"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1086\/520662","volume":"45","year":"2007","unstructured":"Hoff, S. T., M. Abebe, P. Ravn, N. Range, W. Malenganisho, D. S. Rodriques, E. G. Kallas, C. Soborg, T. Mark Doherty, P. Andersen, and K. Weldingh. 2007. Evaluation of Mycobacterium tuberculosis-specific antibody responses in populations with different levels of exposure from Tanzania, Ethiopia, Brazil, and Denmark. Clin. Infect. Dis.45:575-582.","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_2_11_2","first-page":"883","volume":"9","year":"2002","unstructured":"Houghton, R. L., M. J. Lodes, D. C. Dillon, L. D. Reynolds, C. H. Day, P. D. McNeill, R. C. Hendrickson, Y. A. Skeiky, D. P. Sampaio, R. Badaro, K. P. Lyashchenko, and S. G. Reed. 2002. Use of multiepitope polyproteins in serodiagnosis of active tuberculosis. Clin. Diagn. Lab. Immunol.9:883-891.","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00289-07"},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1111\/j.1365-2958.2006.05151.x","volume":"60","year":"2006","unstructured":"Kinhikar, A. G., D. Vargas, H. Li, S. B. Mahaffey, L. Hinds, J. T. Belisle, and S. Laal. 2006. Mycobacterium tuberculosis malate synthase is a laminin-binding adhesin. Mol. Microbiol.60:999-1013.","journal-title":"Mol. Microbiol."},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1056\/NEJM198308253090803","volume":"309","year":"1983","unstructured":"Lane, H. C., H. Masur, L. C. Edgar, G. Whalen, A. H. Rook, and A. S. Fauci. 1983. Abnormalities of B-cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome. N. Engl. J. Med.309:453-458.","journal-title":"N. Engl. J. Med."},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1001\/jama.282.11.1061","volume":"282","year":"1999","unstructured":"Lijmer, J. G., B. W. Mol, S. Heisterkamp, G. J. Bonsel, M. H. Prins, J. H. van der Meulen, and P. M. Bossuyt. 1999. Empirical evidence of design-related bias in studies of diagnostic tests. JAMA282:1061-1066.","journal-title":"JAMA"},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"340","DOI":"10.7326\/0003-4819-146-5-200703060-00006","volume":"146","year":"2007","unstructured":"Menzies, D., M. Pai, and G. Comstock. 2007. Meta-analysis: new tests for the diagnosis of latent tuberculosis infection: areas of uncertainty and recommendations for research. Ann. Intern. Med.146:340-354.","journal-title":"Ann. Intern. Med."},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1128\/CDLI.11.2.280-286.2004","volume":"11","year":"2004","unstructured":"Mukherjee, S., N. Daifalla, Y. Zhang, J. Douglass, L. Brooks, T. Vedvick, R. Houghton, S. G. Reed, and A. Campos-Neto. 2004. Potential serological use of a recombinant protein that is a replica of a Mycobacterium tuberculosis protein found in the urine of infected mice. Clin. Diagn. Lab. Immunol.11:280-286.","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/1471-2334-6-96","volume":"6","year":"2006","unstructured":"Mutapi, F., T. Mduluza, N. Gomez-Escobar, W. F. Gregory, C. Fernandez, N. Midzi, and R. M. Maizels. 2006. Immuno-epidemiology of human Schistosoma haematobium infection: preferential IgG3 antibody responsiveness to a recombinant antigen dependent on age and parasite burden. BMC Infect. Dis.6:96.","journal-title":"BMC Infect. Dis."},{"key":"e_1_3_2_19_2","unstructured":"2006 Annual TB Summary. 2008"},{"key":"e_1_3_2_20_2","first-page":"198","volume":"7","year":"2003","unstructured":"O'Brien, R. J., and E. A. Talbot. 2003. The utility of an antibiotic trial for diagnosis of AFB-negative tuberculosis. Int. J. Tuber. Lung Dis.7:198.","journal-title":"Int. J. Tuber. Lung Dis."},{"key":"e_1_3_2_21_2","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1086\/518656","volume":"196","year":"2007","unstructured":"Perkins, M. D., and J. Cunningham. 2007. Facing the crisis: improving the diagnosis of tuberculosis in the HIV era. J. Infect. Dis.196(Suppl. 1):S15-S27.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1080\/00365540310000292","volume":"35","year":"2003","unstructured":"Ramalingam, B., K. R. Uma Devi, and A. Raja. 2003. Isotype-specific anti-38 and 27 kDa (mpt 51) response in pulmonary tuberculosis with human immunodeficiency virus coinfection. Scand. J. Infect. Dis.35:234-239.","journal-title":"Scand. J. Infect. Dis."},{"key":"e_1_3_2_23_2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.tube.2007.12.001","volume":"88","year":"2008","unstructured":"Rosenkrands, I., C. Aagaard, K. Weldingh, I. Brock, M. H. Dziegiel, M. Singh, S. Hoff, P. Ravn, and P. Andersen. 2008. Identification of Rv0222 from RD4 as a novel serodiagnostic target for tuberculosis. Tuberculosis (Edinburg)88:335-343.","journal-title":"Tuberculosis (Edinburg)"},{"key":"e_1_3_2_24_2","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1503\/cmaj.050090","volume":"174","year":"2006","unstructured":"Rutjes, A. W., J. B. Reitsma, M. Di Nisio, N. Smidt, J. C. van Rijn, and P. M. Bossuyt. 2006. Evidence of bias and variation in diagnostic accuracy studies. CMAJ174:469-476.","journal-title":"CMAJ"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.7.4600-4609.2001"},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1074\/mcp.M600089-MCP200","volume":"5","year":"2006","unstructured":"Sartain, M. J., R. A. Slayden, K. K. Singh, S. Laal, and J. T. Belisle. 2006. Disease state differentiation and identification of tuberculosis biomarkers via native antigen array profiling. Mol. Cell Proteomics5:2102-2113.","journal-title":"Mol. Cell Proteomics"},{"key":"e_1_3_2_27_2","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1128\/CDLI.12.2.354-358.2005","volume":"12","year":"2005","unstructured":"Singh, K. K., Y. Dong, J. T. Belisle, J. Harder, V. K. Arora, and S. Laal. 2005. Antigens of Mycobacterium tuberculosis recognized by antibodies during incipient, subclinical tuberculosis. Clin. Diagn. Lab. Immunol.12:354-358.","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"e_1_3_2_28_2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1086\/376532","volume":"188","year":"2003","unstructured":"Singh, K. K., Y. Dong, L. Hinds, M. A. Keen, J. T. Belisle, S. Zolla-Pazner, J. M. Achkar, A. J. Nadas, V. K. Arora, and S. Laal. 2003. Combined use of serum and urinary antibody for diagnosis of tuberculosis. J. Infect. Dis.188:371-377.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.8.5004-5014.2005"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00355-08"},{"key":"e_1_3_2_31_2","doi-asserted-by":"crossref","first-page":"e202","DOI":"10.1371\/journal.pmed.0040202","volume":"4","year":"2007","unstructured":"Steingart, K. R., M. Henry, S. Laal, P. C. Hopewell, A. Ramsay, D. Menzies, J. Cunningham, K. Weldingh, and M. Pai. 2007. Commercial serological antibody detection tests for the diagnosis of pulmonary tuberculosis: a systematic review. PLoS Med.4:e202.","journal-title":"PLoS Med."},{"key":"e_1_3_2_32_2","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/j.1365-3083.2009.02250.x","volume":"69","year":"2009","unstructured":"Talat, N., F. Shahid, G. Dawood, and R. Hussain. 2009. Dynamic changes in biomarker profiles associated with clinical and subclinical tuberculosis in a high transmission setting: a four-year follow-up study. Scandinavian J. Immunol.69:537-546.","journal-title":"Scandinavian J. Immunol."},{"key":"e_1_3_2_33_2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1471-2334-9-15","volume":"9","year":"2009","unstructured":"Talati, N. J., U. Seybold, B. Humphrey, A. Aina, J. Tapia, P. Weinfurter, R. Albalak, and H. M. Blumberg. 2009. Poor concordance between interferon-gamma release assays and tuberculin skin tests in diagnosis of latent tuberculosis infection among HIV-infected individuals. BMC Infect. Dis.9:15.","journal-title":"BMC Infect. Dis."},{"key":"e_1_3_2_34_2","first-page":"171","volume":"66","year":"1990","unstructured":"Tanaka, S., and T. Suzuki. 1990. Anti-Treponema pallidum IgM, IgA, and IgG subclass antibody responses after treatment in patients with syphilis at various stages: 1. Assessments by enzyme-linked immunosorbent assay. Genitourin Med.66:171-177.","journal-title":"Genitourin Med."},{"key":"e_1_3_2_35_2","first-page":"1","volume":"54","year":"2005","unstructured":"Taylor, Z., C. M. Nolan, and H. M. Blumberg. 2005. Controlling tuberculosis in the United States. Recommendations from the American Thoracic Society, CDC, and the Infectious Diseases Society of America. MMWR Recomm. Rep.54:1-81.","journal-title":"MMWR Recomm. Rep."},{"key":"e_1_3_2_36_2","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1086\/378676","volume":"188","year":"2003","unstructured":"Toossi, Z. 2003. Virological and immunological impact of tuberculosis on human immunodeficiency virus type 1 disease. J. Infect. Dis.188:1146-1155.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_37_2","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1164\/ajrccm.156.2.atsstatement","volume":"156","year":"1997","unstructured":"Wallace, R. J., Jr., J. Glassroth, D. Griffith, K. N. Olivier, J. L. Cook, and F. Gordin. 1997. Diagnosis and treatment of disease caused by nontuberculous mycobacteria. Am. J. Respir. Crit. Care Med.156:S1-S25.","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"e_1_3_2_38_2","doi-asserted-by":"crossref","first-page":"e2071","DOI":"10.1371\/journal.pone.0002071","volume":"3","year":"2008","unstructured":"Wanchu, A., Y. Dong, S. Sethi, V. P. Myneedu, A. Nadas, Z. Liu, J. Belisle, and S. Laal. 2008. Biomarkers for clinical and incipient tuberculosis: performance in a TB-endemic country. PLoS One3:e2071.","journal-title":"PLoS One"},{"key":"e_1_3_2_39_2","unstructured":"The Stop TB strategy. 2006"},{"key":"e_1_3_2_40_2","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.jmb.2003.11.001","volume":"335","year":"2004","unstructured":"Wilson, R. A., W. N. Maughan, L. Kremer, G. S. Besra, and K. Futterer. 2004. The structure of Mycobacterium tuberculosis MPT51 (FbpC1) defines a new family of non-catalytic alpha\/beta hydrolases. J. Mol. Biol.335:519-530.","journal-title":"J. Mol. Biol."}],"container-title":["Clinical and Vaccine Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00503-09","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00503-09","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T20:43:00Z","timestamp":1627591380000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/CVI.00503-09"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["10.1128\/CVI.00503-09"],"URL":"https:\/\/doi.org\/10.1128\/cvi.00503-09","relation":{},"ISSN":["1556-6811","1556-679X"],"issn-type":[{"value":"1556-6811","type":"print"},{"value":"1556-679X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3]]},"assertion":[{"value":"2009-12-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-01-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}