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For the placebo recipients, spirochetes were recovered from 9 (60%) skin biopsy specimens collected after 1 month, and the organisms persisted in the skin thereafter. Ten (67%) dogs also developed joint infection (3 dogs), lameness or synovitis (7 dogs), or<jats:italic>B. burgdorferi<\/jats:italic>-specific antibodies (8 dogs). For the vaccine recipients, spirochetes were recovered from 6 (40%) skin biopsy specimens collected after 1 month. However, subsequent biopsy specimens were negative, and the dogs failed to develop joint infection (<jats:italic>P<\/jats:italic>= 0.224), lameness\/synovitis (<jats:italic>P<\/jats:italic>= 0.006), or Lyme disease-specific antibody responses (<jats:italic>P<\/jats:italic>= 0.002). The bacterin provided a high level of protection for 1 year after immunization, and the addition of the OspC-producing<jats:italic>B. burgdorferi<\/jats:italic>50772 provided enhanced protection.<\/jats:p>","DOI":"10.1128\/cvi.00524-09","type":"journal-article","created":{"date-parts":[[2010,3,18]],"date-time":"2010-03-18T02:15:07Z","timestamp":1268878507000},"page":"870-874","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":25,"title":["One-Year Duration of Immunity Induced by Vaccination with a Canine Lyme Disease Bacterin"],"prefix":"10.1128","volume":"17","author":[{"given":"Rhonda L.","family":"LaFleur","sequence":"first","affiliation":[{"name":"Intervet\/Schering-Plough Animal Health Corporation, Elkhorn, Nebraska 68022"},{"name":"Gundersen Lutheran Medical Center, La Crosse, Wisconsin"},{"name":"University of Wisconsin, Madison, Wisconsin 53706"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven M.","family":"Callister","sequence":"additional","affiliation":[{"name":"Intervet\/Schering-Plough Animal Health Corporation, Elkhorn, Nebraska 68022"},{"name":"Gundersen Lutheran Medical Center, La Crosse, Wisconsin"},{"name":"University of Wisconsin, Madison, Wisconsin 53706"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer C.","family":"Dant","sequence":"additional","affiliation":[{"name":"Intervet\/Schering-Plough Animal Health Corporation, Elkhorn, Nebraska 68022"},{"name":"Gundersen Lutheran Medical Center, La Crosse, Wisconsin"},{"name":"University of Wisconsin, Madison, Wisconsin 53706"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dean A.","family":"Jobe","sequence":"additional","affiliation":[{"name":"Intervet\/Schering-Plough Animal Health Corporation, Elkhorn, Nebraska 68022"},{"name":"Gundersen Lutheran Medical Center, La Crosse, Wisconsin"},{"name":"University of Wisconsin, Madison, Wisconsin 53706"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven D.","family":"Lovrich","sequence":"additional","affiliation":[{"name":"Intervet\/Schering-Plough Animal Health Corporation, Elkhorn, Nebraska 68022"},{"name":"Gundersen Lutheran Medical Center, La Crosse, Wisconsin"},{"name":"University of Wisconsin, Madison, Wisconsin 53706"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas F.","family":"Warner","sequence":"additional","affiliation":[{"name":"Intervet\/Schering-Plough Animal Health Corporation, Elkhorn, Nebraska 68022"},{"name":"Gundersen Lutheran Medical Center, La Crosse, Wisconsin"},{"name":"University of Wisconsin, Madison, Wisconsin 53706"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terri L.","family":"Wasmoen","sequence":"additional","affiliation":[{"name":"Intervet\/Schering-Plough Animal Health Corporation, Elkhorn, Nebraska 68022"},{"name":"Gundersen Lutheran Medical Center, La Crosse, Wisconsin"},{"name":"University of Wisconsin, Madison, Wisconsin 53706"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald F.","family":"Schell","sequence":"additional","affiliation":[{"name":"Intervet\/Schering-Plough Animal Health Corporation, Elkhorn, Nebraska 68022"},{"name":"Gundersen Lutheran Medical Center, La Crosse, Wisconsin"},{"name":"University of Wisconsin, Madison, Wisconsin 53706"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.28.2.363-365.1990"},{"key":"e_1_3_1_3_2","first-page":"908","volume":"9","year":"2002","unstructured":"Callister, S. 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