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Using whole organisms, protective responses were obtained. However, upon exposure to<jats:named-content content-type=\"genus-species\">C. trachomatis<\/jats:named-content>, disease exacerbation developed in some immunized individuals, precluding the implementation of the vaccine. Evidence of the role of<jats:named-content content-type=\"genus-species\">C. trachomatis<\/jats:named-content>as a sexually transmitted pathogen started to emerge in the 1960s, and it soon became evident that it can cause acute infections and long-term sequelae in women, men, and newborns. The main focus of this minireview is to summarize recent findings and discuss formulations, including antigens, adjuvants, routes, and delivery systems for immunization, primarily explored in the female mouse model, with the goal of implementing a vaccine against<jats:named-content content-type=\"genus-species\">C. trachomatis<\/jats:named-content>genital infections.<\/jats:p>","DOI":"10.1128\/cvi.00543-16","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T01:30:30Z","timestamp":1487813430000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":87,"title":["Update on Chlamydia trachomatis Vaccinology"],"prefix":"10.1128","volume":"24","author":[{"given":"Luis M.","family":"de la Maza","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangming","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Brunham","sequence":"additional","affiliation":[{"name":"Vaccine Research Laboratory, University of British Columbia Center for Disease Control, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","volume-title":"Human chlamydial infections","author":"Schachter J","year":"1978","unstructured":"Schachter J DawsonCR. 1978. 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