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By characterizing the IgG response to<jats:named-content content-type=\"genus-species\">Achromobacter xylosoxidans<\/jats:named-content>, we found that HIV-infected participants who were immunoresponsive (<jats:italic>n<\/jats:italic>= 48) had significantly lower CD4 percentages (<jats:italic>P<\/jats:italic>= 0.01), greater CD4 activation (percentages of RA<jats:sup>\u2212<\/jats:sup>CD38<jats:sup>+<\/jats:sup>) (<jats:italic>P<\/jats:italic>= 0.03), and higher soluble CD14 (<jats:italic>P<\/jats:italic>= 0.01). HIV-positive individuals had higher anti-<jats:named-content content-type=\"genus-species\">A. xylosoxidans<\/jats:named-content>IgG titers than HIV-uninfected individuals (<jats:italic>P<\/jats:italic>= 0.04). The results suggest an abnormal adaptive immune activation to gut microflora during HIV infection.<\/jats:p>","DOI":"10.1128\/cvi.00553-13","type":"journal-article","created":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T00:43:57Z","timestamp":1383180237000},"page":"46-50","source":"Crossref","is-referenced-by-count":3,"title":["Antibody Response to Achromobacter xylosoxidans during HIV Infection Is Associated with Lower CD4 Levels and Increased Lymphocyte Activation"],"prefix":"10.1128","volume":"21","author":[{"given":"Erick T.","family":"Tatro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Intan","family":"Purnajo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas D.","family":"Richman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davey M.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Gianella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","published-online":{"date-parts":[[2013,10,30]]},"reference":[{"key":"key20180919073718_B1","doi-asserted-by":"publisher","first-page":"4819","DOI":"10.1073\/pnas.0736332100","article-title":"Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: intrinsic stability predicts lifelong persistence","volume":"100","author":"Strain","year":"2003","journal-title":"Proc. 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