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We previously found a high frequency of<jats:named-content content-type=\"genus-species\">Mycobacterium bovis<\/jats:named-content>DNA in colostrum from dairy cows using a nested PCR to detect<jats:italic>mpb70<\/jats:italic>. Since there are no reliable<jats:italic>in vivo<\/jats:italic>tests to determine the effectiveness of booster<jats:named-content content-type=\"genus-species\">Mycobacterium bovis<\/jats:named-content>BCG vaccination against bTB, in this work we monitored<jats:named-content content-type=\"genus-species\">M. bovis<\/jats:named-content>DNA in colostrum by using this nested PCR. In order to decrease the risk of adverse reactions in animals likely containing viable<jats:named-content content-type=\"genus-species\">M. bovis<\/jats:named-content>, a single application of BCG and a subunit vaccine (EEP-1) formulated with<jats:named-content content-type=\"genus-species\">M. bovis<\/jats:named-content>culture filtrate proteins (CFP) and a copolymer as the adjuvant was performed in tuberculin skin test-negative cattle (TST<jats:sup>\u2212<\/jats:sup>), while TST reactor animals (TST<jats:sup>+<\/jats:sup>) received EEP-1 only. Booster immunization using EEP-1 was applied to both groups, 2 months after primary vaccination to whole herds and 12 months later to lactating cows. Colostrum samples were collected from 6 farms where the cows were vaccinated over a 12-month period postvaccination and, for comparison, from one control farm where the cows were not vaccinated with comparable bTB prevalence. We observed an inverse relationship between the frequency of<jats:named-content content-type=\"genus-species\">M. bovis<\/jats:named-content>DNA detection and time postvaccination at the first (<jats:italic>P<\/jats:italic>&lt; 0.001) and second (<jats:italic>P<\/jats:italic>&lt; 0.0001) 6-month periods. Additionally, the concentration of gamma interferon (IFN-\u03b3) was higher in<jats:italic>mpb70<\/jats:italic>PCR-positive colostrum samples (<jats:italic>P<\/jats:italic>= 0.0003). These results suggest that<jats:named-content content-type=\"genus-species\">M. bovis<\/jats:named-content>DNA frequency in colostrum could be a potentially useful biomarker for bTB vaccine efficacy on commercial dairy farms.<\/jats:p>","DOI":"10.1128\/cvi.00566-12","type":"journal-article","created":{"date-parts":[[2013,2,21]],"date-time":"2013-02-21T07:02:32Z","timestamp":1361430152000},"page":"627-633","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["Mycobacterium bovis DNA Detection in Colostrum as a Potential Indicator of Vaccination Effectiveness against Bovine Tuberculosis"],"prefix":"10.1128","volume":"20","author":[{"given":"Sara E.","family":"Herrera-Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Unidad de Biotecnolog\u00eda M\u00e9dica y Farmac\u00e9utica, Centro de Investigaci\u00f3n y Asistencia en Tecnolog\u00eda y Dise\u00f1o del Estado de Jalisco AC, Guadalajara, Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Alejandra","family":"Gordiano-Hidalgo","sequence":"additional","affiliation":[{"name":"Unidad de Biotecnolog\u00eda M\u00e9dica y Farmac\u00e9utica, Centro de Investigaci\u00f3n y Asistencia en Tecnolog\u00eda y Dise\u00f1o del Estado de Jalisco AC, Guadalajara, Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonz\u00e1lo","family":"L\u00f3pez-Rinc\u00f3n","sequence":"additional","affiliation":[{"name":"Unidad de Biotecnolog\u00eda M\u00e9dica y Farmac\u00e9utica, Centro de Investigaci\u00f3n y Asistencia en Tecnolog\u00eda y Dise\u00f1o del Estado de Jalisco AC, Guadalajara, Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Bojorquez-Narv\u00e1ez","sequence":"additional","affiliation":[{"name":"Productora Nacional de Biol\u00f3gicos Veterinarios-SAGARPA, Mexico DF, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Javier","family":"Padilla-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Departamento de Producci\u00f3n Animal, Centro Universitario de Ciencias Biol\u00f3gicas y Agropecuarias, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Laura","family":"Pereira-Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario Alberto","family":"Flores-Valdez","sequence":"additional","affiliation":[{"name":"Unidad de Biotecnolog\u00eda M\u00e9dica y Farmac\u00e9utica, Centro de Investigaci\u00f3n y Asistencia en Tecnolog\u00eda y Dise\u00f1o del Estado de Jalisco AC, Guadalajara, Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciro","family":"Estrada-Ch\u00e1vez","sequence":"additional","affiliation":[{"name":"Unidad de Biotecnolog\u00eda M\u00e9dica y Farmac\u00e9utica, Centro de Investigaci\u00f3n y Asistencia en Tecnolog\u00eda y Dise\u00f1o del Estado de Jalisco AC, Guadalajara, Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.tvjl.2007.07.001","article-title":"Pathology of naturally occurring bovine tuberculosis in England and Wales","volume":"176","author":"Liebana E","year":"2008","unstructured":"LiebanaE JohnsonL GoughJ DurrP JahansK Clifton-HadleyR SpencerY HewinsonRG DownsSH. 2008. 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