{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:57:22Z","timestamp":1790783842685,"version":"4.1.0"},"reference-count":37,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The therapeutic effects of a controlled parasitic nematode infection on the course of inflammatory bowel disease (IBD) have been demonstrated in both animal and human models. However, the inability of individual well-characterized nematode proteins to recreate these beneficial effects has limited the application of component immunotherapy to human disease. The nematodes that cause chronic human lymphatic filariasis,\n            <jats:named-content content-type=\"genus-species\">Brugia malayi<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">Wuchereria bancrofti<\/jats:named-content>\n            , are among the parasites that induce immune suppression. Filarial lymphatic pathology has been shown to involve NF-\u03baB pathway-dependent production of vascular endothelial growth factor (VEGF), and stimulation of VEGF expression has also been reported by interleukin 8 (IL-8) via NF-\u03baB pathways. Previously, we have shown that the filarial asparaginyl-tRNA synthetase (rBmAsnRS) interacts with IL-8 receptors using a combination of extracellular loops that differ from those bound by IL-8. To test the hypothesis that rBmAsnRS might induce an anti-inflammatory effect\n            <jats:italic>in vivo<\/jats:italic>\n            , we studied the effects of rBmAsnRS in an established murine colitis model using T-cell transfer mice. T-cell transfer colitis mice treated intraperitoneally with 100 \u03bcg of rBmAsnRS four times over 2 weeks showed resolution of cellular infiltration in the colonic mucosa, along with induction of a CD8\n            <jats:sup>+<\/jats:sup>\n            cellular response. In addition, rBmAsnRS induced a rise in IL-10 production from CD3\n            <jats:sup>+<\/jats:sup>\n            and lipopolysaccharide (LPS)- and cytosine phosphate guanosine (CPG)-stimulated splenic cells. In summary, this work demonstrates a novel anti-inflammatory nematode protein, supports the hygiene hypothesis, and supports continued refinement of alternative immunotherapies for treatment of IBD.\n          <\/jats:p>","DOI":"10.1128\/cvi.00594-12","type":"journal-article","created":{"date-parts":[[2012,12,20]],"date-time":"2012-12-20T11:17:30Z","timestamp":1356002250000},"page":"276-281","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":35,"title":["Nematode Asparaginyl-tRNA Synthetase Resolves Intestinal Inflammation in Mice with T-Cell Transfer Colitis"],"prefix":"10.1128","volume":"20","author":[{"given":"Michael A.","family":"Kron","sequence":"first","affiliation":[{"name":"Department of Medicine, Biotechnology and Bioengineering Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Metwali","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, University of Iowa Carver College of Medicine and VAHC, Iowa City, Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanja","family":"Vodanovic-Jankovic","sequence":"additional","affiliation":[{"name":"Department of Medicine, Biotechnology and Bioengineering Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Elliott","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, University of Iowa Carver College of Medicine and VAHC, Iowa City, Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1002\/eji.200324833","article-title":"Heligomosoides polygyrus inhibits established colitis in IL-10 deficient mice","volume":"34","author":"Elliott DE","year":"2004","unstructured":"ElliottDE SetiawanT MetwaliA BlumA UrbanJF WeinstockJV. 2004. 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