{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T17:24:27Z","timestamp":1772040267782,"version":"3.50.1"},"reference-count":58,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Agriculture and Food Research Initiative","award":["2011-67015-30736"],"award-info":[{"award-number":["2011-67015-30736"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            T helper 17 (Th17)-associated cytokines are integral to the immune responses to tuberculosis, initiating both protective and harmful inflammatory responses. The aim of the present study was to evaluate applied aspects of interleukin-17 (IL-17) biology in the context of\n            <jats:named-content content-type=\"genus-species\">Mycobacterium bovis<\/jats:named-content>\n            infection of cattle. Using transcriptome sequencing (RNA-Seq), numerous Th17-associated cytokine genes (including IL-17A, IL-17F, IL-22, IL-19, and IL-27) were upregulated &gt;9-fold in response to purified protein derivative stimulation of peripheral blood mononuclear cells from experimentally\n            <jats:named-content content-type=\"genus-species\">M. bovis<\/jats:named-content>\n            -infected cattle. Protective vaccines elicited IL-17A, IL-17F, IL-22, and IL-27 responses. Reduced IL-17A responses by vaccine recipients, compared to nonvaccinated animals, at 2.5 weeks after\n            <jats:named-content content-type=\"genus-species\">M. bovis<\/jats:named-content>\n            challenge correlated with reduced disease burdens. Additionally, IL-17A and interferon gamma (IFN-\u03b3) responses were highly correlated and exhibited similar diagnostic capacities. The present findings support the use of Th17-associated cytokines as biomarkers of infection and protection in the immune responses to bovine tuberculosis.\n          <\/jats:p>","DOI":"10.1128\/cvi.00637-15","type":"journal-article","created":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T01:39:57Z","timestamp":1450316397000},"page":"168-180","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":47,"title":["Interleukin-17A as a Biomarker for Bovine Tuberculosis"],"prefix":"10.1128","volume":"23","author":[{"given":"W. 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