{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:35:42Z","timestamp":1780410942286,"version":"3.54.1"},"reference-count":33,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"LUA, Sweden","award":["75180"],"award-info":[{"award-number":["75180"]}]},{"name":"Cancer and Allergy Foundation, Sweden"},{"name":"FoU, NU Hospital Group, Sweden"},{"name":"G\u00f6teborg Medical Society, Sweden"},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research, UK","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Patients with multiple myeloma and other B cell disorders respond poorly to pneumococcal vaccination. Vaccine responsiveness is commonly determined by measuring pneumococcal serotype-specific antibodies by enzyme-linked immunosorbent assay (ELISA), by a functional opsonophagocytosis assay (OPA), or by both assays. We compared the two methods in vaccinated elderly patients with multiple myeloma, Waldenstrom's macroglobulinemia, and monoclonal gammopathy of undetermined significance (MGUS). Postvaccination sera from 45 patients (\n            <jats:italic>n<\/jats:italic>\n            = 15 from each patient group) and 15 control subjects were analyzed by multiplexed OPA for pneumococcal serotypes 4, 6B, 14, and 23F, and the results were compared to IgG and IgM antibody titers measured by ELISA. While there were significant correlations between pneumococcal OPA and IgG titers for all serotypes among the control subjects (correlation coefficients [\n            <jats:italic>r<\/jats:italic>\n            ] between 0.51 and 0.85), no significant correlations were seen for any of the investigated serotypes in the myeloma group (\n            <jats:italic>r<\/jats:italic>\n            = \u22120.18 to 0.21) or in the group with Waldenstrom's macroglobulinemia (borderline significant correlations for 2 of 4 serotypes). The MGUS group resembled the control group by having good agreement between the two test methods for 3 of 4 serotypes (\n            <jats:italic>r<\/jats:italic>\n            = 0.53 to 0.80). Pneumococcal postvaccination IgM titers were very low in the myeloma patients compared to the other groups and did not correlate with the OPA results. To summarize, our data indicate that ELISA measurements may overestimate antipneumococcal immunity in elderly subjects with B cell malignancies and that a functional antibody test should be used specifically for myeloma and Waldenstrom's macroglobulinemia patients.\n          <\/jats:p>","DOI":"10.1128\/cvi.00654-15","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T04:13:58Z","timestamp":1456373638000},"page":"379-385","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["Poor Correlation between Pneumococcal IgG and IgM Titers and Opsonophagocytic Activity in Vaccinated Patients with Multiple Myeloma and Waldenstrom's Macroglobulinemia"],"prefix":"10.1128","volume":"23","author":[{"given":"Johanna","family":"Karlsson","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, NU Hospital Group, Trollh\u00e4ttan\/Uddevalla, Sweden"},{"name":"Department of Infectious Diseases, Sahlgrenska Academy, University of Gothenburg, G\u00f6teborg, Sweden"},{"name":"Department of Hematology and Coagulation, Sahlgrenska Academy, University of Gothenburg, G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Roalfe","sequence":"additional","affiliation":[{"name":"Immunobiology Section, Institute of Child Health, University College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harriet","family":"Hogevik","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Sahlgrenska Academy, University of Gothenburg, G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Zancolli","sequence":"additional","affiliation":[{"name":"Immunobiology Section, Institute of Child Health, University College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Andr\u00e9asson","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Internal Medicine, NU Hospital Group, Trollh\u00e4ttan\/Uddevalla, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Goldblatt","sequence":"additional","affiliation":[{"name":"Immunobiology Section, Institute of Child Health, University College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Wenner\u00e5s","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Sahlgrenska Academy, University of Gothenburg, G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2005.01.013"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/605664"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.03144.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.054015"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268810000919"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.107714"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06705.x"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830300202"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(01)00347-4"},{"key":"e_1_3_2_11_2","first-page":"816","article-title":"Use of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine for adults with immunocompromising conditions: recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"61","author":"Centers for Disease Control and Prevention","year":"2012","unstructured":"Centers for Disease Control and Prevention. 2012. 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