{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T03:27:10Z","timestamp":1768274830805,"version":"3.49.0"},"reference-count":39,"publisher":"American Society for Microbiology","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin. Vaccine Immunol."],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>In developing countries,<jats:named-content content-type=\"genus-species\">Shigella<\/jats:named-content>is a primary cause of diarrhea in infants and young children. Although antibiotic therapy is an effective treatment for shigellosis, therapeutic options are narrowing due to the emergence of antibiotic resistance. Thus, preventive vaccination could become the most efficacious approach for controlling shigellosis. We have identified several conserved protein antigens that are shared by multiple<jats:named-content content-type=\"genus-species\">Shigella<\/jats:named-content>serotypes and species. Among these, one antigen induced cross-protection against experimental shigellosis, and we have named it pan-<jats:named-content content-type=\"genus-species\">Shigella<\/jats:named-content>surface protein 1 (PSSP-1). PSSP-1-induced protection requires a mucosal administration route and coadministration of an adjuvant. When PSSP-1 was administered intranasally, it induced cross-protection against<jats:named-content content-type=\"genus-species\">Shigella flexneri<\/jats:named-content>serotypes 2a, 5a, and 6,<jats:named-content content-type=\"genus-species\">Shigella boydii<\/jats:named-content>,<jats:named-content content-type=\"genus-species\">Shigella sonnei<\/jats:named-content>, and<jats:named-content content-type=\"genus-species\">Shigella dysenteriae<\/jats:named-content>serotype 1. Intradermally administered PSSP-1 induced strong serum antibody responses but failed to induce protection in the mouse lung pneumonia model. In contrast, intranasal administration elicited efficient local and systemic antibody responses and production of interleukin 17A and gamma interferon. Interestingly, blood samples from patients with recent-onset shigellosis showed variable but significant mucosal antibody responses to other conserved<jats:named-content content-type=\"genus-species\">Shigella<\/jats:named-content>protein antigens but not to PSSP-1. We suggest that PSSP-1 is a promising antigen for a broadly protective vaccine against<jats:named-content content-type=\"genus-species\">Shigella<\/jats:named-content>.<\/jats:p>","DOI":"10.1128\/cvi.00661-14","type":"journal-article","created":{"date-parts":[[2015,2,5]],"date-time":"2015-02-05T03:19:58Z","timestamp":1423106398000},"page":"381-388","source":"Crossref","is-referenced-by-count":26,"title":["Shigella Outer Membrane Protein PSSP-1 Is Broadly Protective against Shigella Infection"],"prefix":"10.1128","volume":"22","author":[{"given":"Jae-Ouk","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Semi","family":"Rho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su 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