{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T08:34:52Z","timestamp":1775205292731,"version":"3.50.1"},"reference-count":19,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Worldwide, the\n            <jats:named-content content-type=\"genus-species\">Mycobacterium bovis<\/jats:named-content>\n            BCG vaccine is one of the most widely used vaccines. However, it appears to be ineffective in preventing pulmonary tuberculosis. Here, we show that pulmonary BCG vaccination of mice with a broad dose range provides superior protection against\n            <jats:named-content content-type=\"genus-species\">Mycobacterium tuberculosis<\/jats:named-content>\n            challenge compared to that of subcutaneous vaccination.\n          <\/jats:p>","DOI":"10.1128\/cvi.00700-13","type":"journal-article","created":{"date-parts":[[2014,2,6]],"date-time":"2014-02-06T03:09:28Z","timestamp":1391656168000},"page":"594-597","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":47,"title":["Pulmonary Mycobacterium bovis BCG Vaccination Confers Dose-Dependent Superior Protection Compared to That of Subcutaneous Vaccination"],"prefix":"10.1128","volume":"21","author":[{"given":"Nacho","family":"Aguilo","sequence":"first","affiliation":[{"name":"Grupo de Gen\u00e9tica de Micobacterias, Departmento de Microbiolog\u00eda, Medicina Preventiva y Salud P\u00fablica, Faculty of Medicine, Universidad de Zaragoza, Zaragoza, Spain"},{"name":"CIBER Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Maria","family":"Toledo","sequence":"additional","affiliation":[{"name":"Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva Maria","family":"Lopez-Roman","sequence":"additional","affiliation":[{"name":"Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Perez-Herran","sequence":"additional","affiliation":[{"name":"Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eamonn","family":"Gormley","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University College Dublin (UCD), Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaquin","family":"Rullas-Trincado","sequence":"additional","affiliation":[{"name":"Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I\u00f1igo","family":"Angulo-Barturen","sequence":"additional","affiliation":[{"name":"Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Martin","sequence":"additional","affiliation":[{"name":"Grupo de Gen\u00e9tica de Micobacterias, Departmento de Microbiolog\u00eda, Medicina Preventiva y Salud P\u00fablica, Faculty of Medicine, Universidad de Zaragoza, Zaragoza, Spain"},{"name":"CIBER Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain"},{"name":"Servicio de Microbiolog\u00eda, Hospital Universitario Miguel Servet, IIS Arag\u00f3n, Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1211"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.2013.856765"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60177-4"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2006.12.006"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/02770906809100348"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.1.238-246.2004"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.2.1065-1071.2004"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.4049\/jimmunol.171.3.1602","article-title":"Enhanced immunogenicity and protective efficacy against Mycobacterium tuberculosis of Bacille Calmette-Guerin vaccine using mucosal administration and boosting with a recombinant modified vaccinia virus Ankara","volume":"171","author":"Goonetilleke NP","year":"2003","unstructured":"GoonetillekeNPMcShaneHHannanCMAndersonRJBrookesRHHillAVS. 2003. Enhanced immunogenicity and protective efficacy against Mycobacterium tuberculosis of Bacille Calmette-Guerin vaccine using mucosal administration and boosting with a recombinant modified vaccinia virus Ankara. J. Immunol. 171:1602\u20131609.","journal-title":"J. Immunol."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00526-08"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1054\/tube.2002.0340"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02648.x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.3.1410-1416.2002"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0962-8479(93)90067-8"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.12.6946-6953.2000"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02573.x"},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"976","DOI":"10.4049\/jimmunol.178.2.976","article-title":"CD27low CD4 T lymphocytes that accumulate in the mouse lungs during mycobacterial infection differentiate from CD27high precursors in situ, produce IFN-\u03b3, and protect the host against tuberculosis infection","volume":"178","author":"Kapina MA","year":"2007","unstructured":"KapinaMAShepelkovaGSMischenkoVVSaylesPBogachevaPWinslowGAptASLyadovaIV. 2007. CD27low CD4 T lymphocytes that accumulate in the mouse lungs during mycobacterial infection differentiate from CD27high precursors in situ, produce IFN-\u03b3, and protect the host against tuberculosis infection. J. Immunol. 178:976\u2013985.","journal-title":"J. Immunol."},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197504)35:4<1088::AID-CNCR2820350411>3.0.CO;2-2"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-1108-7"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.07.086"}],"container-title":["Clinical and Vaccine Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00700-13","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.00700-13","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T20:50:42Z","timestamp":1627591842000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/CVI.00700-13"}},"subtitle":[],"editor":[{"given":"M. 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