{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:41:03Z","timestamp":1791333663778,"version":"4.3.1"},"reference-count":42,"publisher":"American Society for Microbiology","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin. Vaccine Immunol."],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:named-content content-type=\"genus-species\">Streptococcus pneumoniae<\/jats:named-content>serotype 1 (Sp1) constitutes an important cause of seasonal endemic meningitis in all age groups in the African meningitis belt. Despite a higher meningitis incidence, the Burkinab\u00e9 population has an Sp1-specific antibody seroprevalence similar to that reported in the United Kingdom (UK). We aimed to establish whether the opsonophagocytic activity (OPA) of pneumococcal IgG naturally present in Burkina Faso differs from that seen in individuals in the UK and to compare the OPAs generated by natural and vaccine-induced immunity. Samples collected from pneumococcal vaccine-naive Burkinab\u00e9 and UK subjects were matched for age (1 to 39 years) and anti-Sp1 IgG level, analyzed for OPA to 3<jats:named-content content-type=\"genus-species\">S. pneumoniae<\/jats:named-content>serotypes (1, 5, and 19A), and compared to postvaccine samples. Furthermore, the Burkinab\u00e9 samples were assessed for IgG avidity and serotype-specific IgM concentrations. One hundred sixty-nine matched serum samples from both populations were selected. A greater proportion of Burkinab\u00e9 subjects aged 1 to 19 years had functional Sp1 activity (OPA \u2265 8) compared to UK subjects (12% versus 2%,<jats:italic>P<\/jats:italic>&lt; 0.001); however, the proportions were similar among adults (9%). The correlation between Sp1 IgG concentration and OPA was good (<jats:italic>P<\/jats:italic>&lt; 0.001), but many individuals had nonfunctional IgG, which was not related to avidity. While the Sp1 IgM concentrations correlated with OPA, not all of the function in serum samples with low IgG could be attributed to IgM. Finally, vaccine-induced Sp1-specific IgG was more functional than equivalent amounts of naturally occurring IgG. In conclusion, despite a substantially higher pneumococcal meningitis incidence, no decreased functional immunity to Sp1 could be evidenced in the Burkinab\u00e9 population compared to that in the population from the UK. Furthermore, the naturally induced antibodies were less functional than vaccine-induced antibodies.<\/jats:p>","DOI":"10.1128\/cvi.00758-14","type":"journal-article","created":{"date-parts":[[2015,2,5]],"date-time":"2015-02-05T03:19:58Z","timestamp":1423106398000},"page":"404-412","source":"Crossref","is-referenced-by-count":11,"title":["Streptococcus pneumoniae Serotype 1 Burden in the African Meningitis Belt: Exploration of Functionality in Specific Antibodies"],"prefix":"10.1128","volume":"22","author":[{"given":"S.","family":"Blumental","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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