{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T03:42:23Z","timestamp":1773373343975,"version":"3.50.1"},"reference-count":41,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Cryptosporidiosis is a ubiquitous infectious disease, caused by the protozoan parasites\n            <jats:named-content content-type=\"genus-species\">Cryptosporidium hominis<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">Cryptosporidium parvum<\/jats:named-content>\n            , leading to acute, persistent, and chronic diarrhea with life-threatening consequences in immunocompromised individuals. In developing countries, cryptosporidiosis in early childhood has been associated with subsequent significant impairment in growth, physical fitness, and intellectual abilities. Currently, vaccines are unavailable and chemotherapeutics are toxic and impractical, and agents for immunoprophylaxis or treatment of cryptosporidiosis are a high priority. Availability of the genome sequences for\n            <jats:named-content content-type=\"genus-species\">C. hominis<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">C. parvum<\/jats:named-content>\n            provides new opportunities to procure and examine novel vaccine candidates. Using the novel approach of \u201creverse vaccinology,\u201d we identified several new potential vaccine candidates. Three of these antigens\u2014Cp15, profilin, and a\n            <jats:named-content content-type=\"genus-species\">Cryptosporidium<\/jats:named-content>\n            apyrase\u2014were delivered in heterologous prime-boost regimens as fusions with cytolysin A (ClyA) in a\n            <jats:named-content content-type=\"genus-species\">Salmonella<\/jats:named-content>\n            live vaccine vector and as purified recombinant antigens, and they were found to induce specific and potent humoral and cellular immune responses, suggesting their potential as new vaccinogens against\n            <jats:named-content content-type=\"genus-species\">Cryptosporidium<\/jats:named-content>\n            infection.\n          <\/jats:p>","DOI":"10.1128\/cvi.05197-11","type":"journal-article","created":{"date-parts":[[2011,9,15]],"date-time":"2011-09-15T09:32:17Z","timestamp":1316079137000},"page":"1796-1802","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":55,"title":["Identification and Immunological Characterization of Three Potential Vaccinogens against Cryptosporidium Species"],"prefix":"10.1128","volume":"18","author":[{"given":"Patricio A.","family":"Manque","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia"},{"name":"Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Tenjo","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia"},{"name":"Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ute","family":"Woehlbier","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia"},{"name":"Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana M.","family":"Lara","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia"},{"name":"Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myrna G.","family":"Serrano","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia"},{"name":"Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o M.","family":"Alves","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia"},{"name":"Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald B.","family":"Smeltz","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel H.","family":"Conrad","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia"},{"name":"Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory A.","family":"Buck","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia"},{"name":"Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1126\/science.1094786","article-title":"Complete genome sequence of the apicomplexan, Cryptosporidium parvum","volume":"304","author":"Abrahamsen M. 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