{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:41:17Z","timestamp":1785894077559,"version":"3.56.0"},"reference-count":59,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Lyme disease is caused by the spirochete\n            <jats:named-content content-type=\"genus-species\">Borrelia burgdorferi<\/jats:named-content>\n            . The enzootic cycle of this pathogen requires that\n            <jats:named-content content-type=\"genus-species\">Ixodes<\/jats:named-content>\n            spp. acquire\n            <jats:named-content content-type=\"genus-species\">B. burgdorferi<\/jats:named-content>\n            from infected wildlife reservoirs and transmit it to other uninfected wildlife. At present, there are no effective measures to control\n            <jats:named-content content-type=\"genus-species\">B. burgdorferi<\/jats:named-content>\n            ; there is no human vaccine available, and existing vector control measures are generally not acceptable to the public. However, if\n            <jats:named-content content-type=\"genus-species\">B. burgdorferi<\/jats:named-content>\n            could be eliminated from its reservoir hosts or from the ticks that feed on them, the enzootic cycle would be broken, and the incidence of Lyme disease would decrease. We developed OspA-RTV, a reservoir targeted bait vaccine (RTV) based on the immunogenic outer surface protein A (OspA) of\n            <jats:named-content content-type=\"genus-species\">B. burgdorferi<\/jats:named-content>\n            aimed at breaking the natural cycle of this spirochete. White-footed mice, the major reservoir species for this spirochete in nature developed a systemic OspA-specific IgG response as a result of ingestion of the bait formulation. This immune response protected white-footed mice against\n            <jats:named-content content-type=\"genus-species\">B. burgdorferi<\/jats:named-content>\n            infection upon tick challenge and cleared\n            <jats:named-content content-type=\"genus-species\">B. burgdorferi<\/jats:named-content>\n            from the tick vector. In performing extensive studies to optimize the OspA-RTV for field deployment, we determined that mice that consumed the vaccine over periods of 1 or 4 months developed a yearlong, neutralizing anti-OspA systemic IgG response. Furthermore, we defined the minimum number of OspA-RTV units needed to induce a protective immune response.\n          <\/jats:p>","DOI":"10.1128\/cvi.05226-11","type":"journal-article","created":{"date-parts":[[2011,9,15]],"date-time":"2011-09-15T09:32:17Z","timestamp":1316079137000},"page":"1809-1816","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":50,"title":["Reservoir Targeted Vaccine for Lyme Borreliosis Induces a Yearlong, Neutralizing Antibody Response to OspA in White-Footed Mice"],"prefix":"10.1128","volume":"18","author":[{"given":"Luciana","family":"Meirelles Richer","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Aroso","sequence":"additional","affiliation":[{"name":"Biopeptides Corp., Memphis, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Contente-Cuomo","sequence":"additional","affiliation":[{"name":"Biopeptides Corp., Memphis, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larisa","family":"Ivanova","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Gomes-Solecki","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee"},{"name":"Biopeptides Corp., Memphis, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"S1451","DOI":"10.1093\/clinids\/11.Supplement_6.S1451","article-title":"Epizootiology of Borrelia in Ixodes tick vectors and reservoir hosts","volume":"11","author":"Anderson J. 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