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In this study, we inserted overlapping sequences encoding the carboxy terminus of the<jats:italic>Helicobacter pylori katA<\/jats:italic>gene product into HBsAg-S. The HBsAg-S\u2013KatA fusion proteins were able to assemble into secretion-competent VLPs (VLP-KatA). The VLP-KatA proteins were able to induce KatA-specific antibodies in immunized mice. The mean total IgG antibody titers 41 days post-primary immunization with VLP-KatA (2.3 \u00d7 10<jats:sup>3<\/jats:sup>) were significantly greater (<jats:italic>P<\/jats:italic>&lt; 0.05) than those observed for vaccination with VLP alone (5.2 \u00d7 10<jats:sup>2<\/jats:sup>). Measurement of IgG isotypes revealed responses to both IgG1 and IgG2a (mean titers, 9.0 \u00d7 10<jats:sup>4<\/jats:sup>and 2.6 \u00d7 10<jats:sup>4<\/jats:sup>, respectively), with the IgG2a response to vaccination with VLP-KatA being significantly higher than that for mice immunized with KatA alone (<jats:italic>P<\/jats:italic>&lt; 0.05). Following challenge of mice with<jats:named-content content-type=\"genus-species\">H. pylori<\/jats:named-content>, a significantly reduced bacterial load in the gastric mucosa was observed (<jats:italic>P<\/jats:italic>&lt; 0.05). This is the first report describing the use of VLPs as a delivery vehicle for<jats:named-content content-type=\"genus-species\">H. pylori<\/jats:named-content>antigens.<\/jats:p>","DOI":"10.1128\/cvi.05295-11","type":"journal-article","created":{"date-parts":[[2011,12,29]],"date-time":"2011-12-29T02:17:33Z","timestamp":1325125053000},"page":"268-276","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["Immunological Response to Parenteral Vaccination with Recombinant Hepatitis B Virus Surface Antigen Virus-Like Particles Expressing Helicobacter pylori KatA Epitopes in a Murine H. pylori Challenge Model"],"prefix":"10.1128","volume":"19","author":[{"given":"Michael","family":"Kotiw","sequence":"first","affiliation":[{"name":"Centre for Systems Biology, University of Southern Queensland, Toowoomba, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Johnson","sequence":"additional","affiliation":[{"name":"Centre for Systems Biology, University of Southern Queensland, Toowoomba, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manisha","family":"Pandey","sequence":"additional","affiliation":[{"name":"Institute for Glycomics, Griffith University, Southport, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Fry","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart L.","family":"Hazell","sequence":"additional","affiliation":[{"name":"Centre for Systems Biology, University of Southern Queensland, Toowoomba, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans J.","family":"Netter","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Monash University, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F.","family":"Good","sequence":"additional","affiliation":[{"name":"Institute for Glycomics, Griffith University, Southport, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Olive","sequence":"additional","affiliation":[{"name":"Queensland Institute of Medical Research, Herston, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1099\/00222615-26-4-265","article-title":"Cross-protection of infant mice against intestinal colonisation by Campylobacter jejuni: importance of heat-labile serotyping (Lior) antigens","volume":"26","author":"Abimiku AG","year":"1988","unstructured":"AbimikuAG DolbyJM. 1988. 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