{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:27:07Z","timestamp":1761488827431},"reference-count":29,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The hepatitis A virus cellular receptor 1 (HAVCR1) gene is highly polymorphic, and several variants have been associated with susceptibility to allergic and autoimmune diseases. The HAVCR1 gene region was identified as a candidate for hepatitis C virus (HCV) natural clearance in a genotyping study of selected immune response genes in both European-American and African-American populations. The aim of the present study was to explore the influence of HAVCR1 in the outcome of HCV infection in the Spanish population. Three cohorts, consisting of 354 subjects with persistent HCV infection (285 with persistent HCV monoinfection and 69 with natural clearance), 182 coinfected HIV\/HCV patients, and 320 controls, were included. Samples were genotyped in several polymorphic positions, insertion\/deletion variants in exon 4 and tag single nucleotide polymorphisms (SNPs), in order to define previously described HAVCR1 haplotypes (haplotypes A to D). No statistically significant differences were observed with spontaneous resolution of infection or with viral clearance after treatment. Nevertheless, different rates of infection by viral genotypes (G's) were observed among the HAVCR1 haplotypes. Individuals bearing haplotype C had the highest viral G1 infection rate when compared to individuals bearing other haplotypes (75.82% versus 57.72%, respectively; corrected<jats:italic>P<\/jats:italic>value [<jats:italic>P<\/jats:italic><jats:sub>c<\/jats:sub>], 3.2 \u00d7 10<jats:sup>\u22124<\/jats:sup>; odds ratio [OR], 2.30; 95% confidence interval [CI], 1.51 to 3.47). Thus, HAVCR1 could be involved in susceptibility or resistance to infection by a particular HCV genotype.<\/jats:p>","DOI":"10.1128\/cvi.05305-11","type":"journal-article","created":{"date-parts":[[2011,12,22]],"date-time":"2011-12-22T05:07:55Z","timestamp":1324530475000},"page":"223-227","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["HAVCR1 Gene Haplotypes and Infection by Different Viral Hepatitis C Virus Genotypes"],"prefix":"10.1128","volume":"19","author":[{"given":"Cristina","family":"Abad-Molina","sequence":"first","affiliation":[{"name":"Servicio de Inmunolog\u00eda, Hospital Universitario Virgen del Roc\u00edo\/Instituto de Biomedicina, Sevilla"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9-Ra\u00fal","family":"Garcia-Lozano","sequence":"additional","affiliation":[{"name":"Servicio de Inmunolog\u00eda, Hospital Universitario Virgen del Roc\u00edo\/Instituto de Biomedicina, Sevilla"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco-Antonio","family":"Montes-Cano","sequence":"additional","affiliation":[{"name":"Servicio de Inmunolog\u00eda, Hospital Universitario Virgen del Roc\u00edo\/Instituto de Biomedicina, Sevilla"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Almudena","family":"Torres-Cornejo","sequence":"additional","affiliation":[{"name":"Servicio de Enfermedades Infecciosas, Hospital Universitario Virgen del Roc\u00edo\/Instituto de Biomedicina, Sevilla"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuensanta","family":"Torrecillas","sequence":"additional","affiliation":[{"name":"Servicio de Inmunolog\u00eda, Hospital Universitario Virgen del Roc\u00edo\/Instituto de Biomedicina, Sevilla"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Aguilar-Reina","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo, Hospital Universitario Virgen del Roc\u00edo\/Instituto de Biomedicina, Sevilla"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Romero-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Secci\u00f3n Hepatolog\u00eda, Hospital Universitario de Valme, Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis-Fernando","family":"L\u00f3pez-Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Servicio de Enfermedades Infecciosas, Hospital Universitario Virgen del Roc\u00edo\/Instituto de Biomedicina, Sevilla"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"N\u00fa\u00f1ez-Roldan","sequence":"additional","affiliation":[{"name":"Servicio de Inmunolog\u00eda, Hospital Universitario Virgen del Roc\u00edo\/Instituto de Biomedicina, Sevilla"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda-Francisca","family":"Gonz\u00e1lez-Escribano","sequence":"additional","affiliation":[{"name":"Servicio de Inmunolog\u00eda, Hospital Universitario Virgen del Roc\u00edo\/Instituto de Biomedicina, Sevilla"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/gepi.10323","article-title":"Maximum-likelihood estimation of haplotype frequencies in nuclear families","volume":"27","author":"Becker T","year":"2004","unstructured":"BeckerT KnappM. 2004. 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Identification of HAVCR1 gene haplotypes associated with mRNA expression levels and susceptibility to autoimmune diseases. Hum. Genet. 128:221\u2013229.","journal-title":"Hum. Genet."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08309"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/hep.24049","article-title":"Linkage of hepatitis C viral genotype and interleukin-28B genetic polymorphisms in Asian patients","volume":"53","author":"Huang CF","year":"2011","unstructured":"HuangCF DaiCY HuangJF ChuangWL YuML. 2011. Linkage of hepatitis C viral genotype and interleukin-28B genetic polymorphisms in Asian patients. Hepatology 53:367\u2013368. 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