{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:15:13Z","timestamp":1790511313754,"version":"4.1.0"},"reference-count":42,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Caprine tuberculosis (TB) has increased in recent years, highlighting the need to address the problem the infection poses in goats. Moreover, goats may represent a cheaper alternative for testing of prototype vaccines in large ruminants and humans. With this aim, a\n                    <jats:named-content content-type=\"genus-species\">Mycobacterium caprae<\/jats:named-content>\n                    infection model has been developed in goats. Eleven 6-month-old goats were infected by the endobronchial route with 1.5 \u00d7 10\n                    <jats:sup>3<\/jats:sup>\n                    CFU, and two other goats were kept as noninfected controls. The animals were monitored for clinical and immunological parameters throughout the experiment. After 14 weeks, the goats were euthanized, and detailed postmortem analysis of lung lesions was performed by multidetector computed tomography (MDCT) and direct observation. The respiratory lymph nodes were also evaluated and cultured for bacteriological analysis. All infected animals were positive in a single intradermal comparative cervical tuberculin (SICCT) test at 12 weeks postinfection (p.i.). Gamma interferon (IFN-\u03b3) antigen-specific responses were detected from 4 weeks p.i. until the end of the experiment. The humoral response to MPB83 was especially strong at 14 weeks p.i. (13 days after SICCT boost). All infected animals presented severe TB lesions in the lungs and associated lymph nodes.\n                    <jats:named-content content-type=\"genus-species\">M. caprae<\/jats:named-content>\n                    was recovered from pulmonary lymph nodes in all inoculated goats. MDCT allowed a precise quantitative measure of TB lesions. Lesions in goats induced by\n                    <jats:named-content content-type=\"genus-species\">M. caprae<\/jats:named-content>\n                    appeared to be more severe than those induced in cattle by\n                    <jats:named-content content-type=\"genus-species\">M. bovis<\/jats:named-content>\n                    over a similar period of time. The present work proposes a reliable new experimental animal model for a better understanding of caprine tuberculosis and future development of vaccine trials in this and other species.\n                  <\/jats:p>","DOI":"10.1128\/cvi.05323-11","type":"journal-article","created":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T07:31:15Z","timestamp":1314862275000},"page":"1872-1881","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":72,"title":["Experimental Model of Tuberculosis in the Domestic Goat after Endobronchial Infection with Mycobacterium caprae"],"prefix":"10.1128","volume":"18","author":[{"given":"Bernat","family":"P\u00e9rez de Val","sequence":"first","affiliation":[{"name":"Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Catalonia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"L\u00f3pez-Soria","sequence":"additional","affiliation":[{"name":"Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Catalonia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miquel","family":"Nofrar\u00edas","sequence":"additional","affiliation":[{"name":"Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Catalonia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maite","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Catalonia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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