{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:16:01Z","timestamp":1792707361294,"version":"4.5.0"},"reference-count":26,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>A comparative study was conducted using data from naive bison (<jats:italic>n<\/jats:italic>= 45) and cattle (<jats:italic>n<\/jats:italic>= 46) from 8 and 6 studies, respectively, in which a standardized<jats:named-content content-type=\"genus-species\">Brucella abortus<\/jats:named-content>strain 2308 experimental challenge was administered during midgestation. The incidence of abortion, fetal infection, uterine or mammary infection, or infection in maternal tissues after experimental challenge was greater (<jats:italic>P<\/jats:italic>&lt; 0.05) in bison than in cattle. In animals that did abort, the time between experimental challenge and abortion was shorter (<jats:italic>P<\/jats:italic>&lt; 0.05) for bison than for cattle.<jats:named-content content-type=\"genus-species\">Brucella<\/jats:named-content>colonization of four target tissues and serologic responses on the standard tube agglutination test at the time of abortion did not differ (<jats:italic>P<\/jats:italic>&gt; 0.05) between cattle and bison. The results of our study suggest that naive bison and cattle have similarities and differences after experimental exposure to a virulent<jats:named-content content-type=\"genus-species\">B. abortus<\/jats:named-content>strain. Although our data suggest that bison may be more susceptible to infection with<jats:named-content content-type=\"genus-species\">Brucella<\/jats:named-content>, some pathogenic characteristics of brucellosis were similar between bison and cattle.<\/jats:p>","DOI":"10.1128\/cvi.05383-11","type":"journal-article","created":{"date-parts":[[2011,10,6]],"date-time":"2011-10-06T06:07:38Z","timestamp":1317881258000},"page":"2075-2078","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":26,"title":["Comparison of Abortion and Infection after Experimental Challenge of Pregnant Bison and Cattle with Brucella abortus Strain 2308"],"prefix":"10.1128","volume":"18","author":[{"given":"S. C.","family":"Olsen","sequence":"first","affiliation":[{"name":"Infectious Bacterial Diseases of Livestock Research Unit, National Animal Disease, Center, Agricultural Research Service, United States Department of Agriculture, Ames, Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Infectious Bacterial Diseases of Livestock Research Unit, National Animal Disease, Center, Agricultural Research Service, United States Department of Agriculture, Ames, Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","first-page":"17","volume-title":"Techniques for the brucellosis laboratory","author":"Alton G. G.","year":"1988","unstructured":"AltonG. G. JonesL. M. AngusR. D. VergerJ. M. (ed.) 1988. Techniques for the brucellosis laboratory, p. 17\u2013136. Institut National de la Recherche Agronomique, Paris, France."},{"key":"e_1_3_1_3_2","first-page":"130","article-title":"Statistical considerations of controlled experiments in brucellosis","volume":"10","author":"Berman D. T.","year":"1949","unstructured":"BermanD. T. IrwinM. R. BeachB. A.. 1949. Statistical considerations of controlled experiments in brucellosis. Am. J. Vet. Res. 10:130\u2013137.","journal-title":"Am. J. Vet. Res."},{"key":"e_1_3_1_4_2","volume-title":"Brucellosis in the greater Yellowstone area","author":"Cheville N. F.","year":"1998","unstructured":"ChevilleN. F. McColloughD. R. PaulsonL. R.. 1998. Brucellosis in the greater Yellowstone area. National Academy Press, Washington, DC."},{"key":"e_1_3_1_5_2","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.2460\/ajvr.1996.57.08.1153","article-title":"Effects of age at vaccination on efficacy of Brucella abortus strain RB51 to protect cattle against brucellosis","volume":"57","author":"Cheville N. F.","year":"1996","unstructured":"ChevilleN. F. OlsenS. C. JensenA. E. StevensM. G. PalmerM. V.. 1996. Effects of age at vaccination on efficacy of Brucella abortus strain RB51 to protect cattle against brucellosis. Am. J. Vet. Res. 57:1153\u20131156.","journal-title":"Am. J. Vet. Res."},{"key":"e_1_3_1_6_2","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.2460\/ajvr.1993.54.10.1591","article-title":"Immune responses and protection against infection and abortion in cattle experimentally vaccinated with mutant strains of Brucella abortus","volume":"54","author":"Cheville N. F.","year":"1993","unstructured":"ChevilleN. F. StevensM. G. JensenA. E. TatumF. M. HallingS. M.. 1993. Immune responses and protection against infection and abortion in cattle experimentally vaccinated with mutant strains of Brucella abortus. Am. J. Vet. Res. 54:1591\u20131597.","journal-title":"Am. J. Vet. Res."},{"key":"e_1_3_1_7_2","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/0378-1135(85)90065-3","article-title":"Effects of challenge dose on the clinical and immune responses of cattle vaccine with reduced doses of Brucella abortus strain 19","volume":"10","author":"Confer A. Q.","year":"1985","unstructured":"ConferA. Q.. 1985. Effects of challenge dose on the clinical and immune responses of cattle vaccine with reduced doses of Brucella abortus strain 19. Vet. Microbiol. 10:561\u2013575.","journal-title":"Vet. Microbiol."},{"key":"e_1_3_1_8_2","doi-asserted-by":"crossref","first-page":"258","DOI":"10.7589\/0090-3558-27.2.258","article-title":"Brucella abortus in bison. II. Evaluation of strain 19 vaccination of pregnant cows","volume":"27","author":"Davis D. S.","year":"1991","unstructured":"DavisD. S.. 1991. Brucella abortus in bison. II. Evaluation of strain 19 vaccination of pregnant cows. J. Wildl. Dis. 27:258\u2013264.","journal-title":"J. Wildl. Dis."},{"key":"e_1_3_1_9_2","first-page":"89","article-title":"Further studies on duration of immunity to brucellosis induced in calf-vaccinated cattle with strain 19 vaccine","volume":"60","author":"Goode E. R.","year":"1956","unstructured":"GoodeE. R. MantheiC. A. AmeraultT. E.. 1956. Further studies on duration of immunity to brucellosis induced in calf-vaccinated cattle with strain 19 vaccine. Proc. U. S. Livestock Sanitary Assoc. 60:89\u201396.","journal-title":"Proc. U. S. Livestock Sanitary Assoc."},{"key":"e_1_3_1_10_2","first-page":"223","article-title":"Effects of exogenous recombinant interleukin-12 on immune responses and protection against Brucella abortus in a murine model","volume":"65","author":"Lee L.-K.","year":"2001","unstructured":"LeeL.-K. OlsenS. C. BolinC. A.. 2001. Effects of exogenous recombinant interleukin-12 on immune responses and protection against Brucella abortus in a murine model. Can. J. Vet. Res. 65:223\u2013228.","journal-title":"Can. J. Vet. Res."},{"key":"e_1_3_1_11_2","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.3168\/jds.S0022-0302(68)87138-3","article-title":"Application of research to bovine brucellosis control and eradication programs","volume":"51","author":"Manthei C. A.","year":"1950","unstructured":"MantheiC. A.. 1950. Application of research to bovine brucellosis control and eradication programs. J. Dairy Sci. 51:1115\u20131120.","journal-title":"J. Dairy Sci."},{"key":"e_1_3_1_12_2","first-page":"91","article-title":"Summary of controlled research with strain 19","volume":"63","author":"Manthei C. A.","year":"1959","unstructured":"MantheiC. A.. 1959. Summary of controlled research with strain 19. Proc. U. S. Livestock Sanitary Assoc. 63:91\u201397.","journal-title":"Proc. U. S. Livestock Sanitary Assoc."},{"key":"e_1_3_1_13_2","doi-asserted-by":"crossref","first-page":"579","DOI":"10.7589\/0090-3558-31.4.579","article-title":"Brucellosis in free-ranging bison (Bison bison) in Yellowstone, Grand Teton, and Wood Buffalo National Parks: a review","volume":"31","author":"Meyer M. E.","year":"1995","unstructured":"MeyerM. E. MeagherM.. 1995. Brucellosis in free-ranging bison (Bison bison) in Yellowstone, Grand Teton, and Wood Buffalo National Parks: a review. J. Wildl. Dis. 31:579\u2013598.","journal-title":"J. Wildl. Dis."},{"key":"e_1_3_1_14_2","first-page":"183","article-title":"Immune responses and efficacy after administration of a commercial Brucella abortus strain RB51 vaccine to cattle","volume":"1","author":"Olsen S. C.","year":"2000","unstructured":"OlsenS. C.. 2000. Immune responses and efficacy after administration of a commercial Brucella abortus strain RB51 vaccine to cattle. Vet. Ther. 1:183\u2013191.","journal-title":"Vet. Ther."},{"key":"e_1_3_1_15_2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1053\/rvsc.2000.0405","article-title":"Responses of adult cattle to vaccination with a reduced dose of Brucella abortus strain RB51","volume":"69","author":"Olsen S. C.","year":"2000","unstructured":"OlsenS. C.. 2000. Responses of adult cattle to vaccination with a reduced dose of Brucella abortus strain RB51. Res. Vet. Sci. 69:135\u2013160.","journal-title":"Res. Vet. Sci."},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00419-08"},{"key":"e_1_3_1_17_2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1053\/rvsc.1998.0251","article-title":"Responses of cattle to two dosages of Brucella abortus strain RB51: serology, clearance and efficacy","volume":"66","author":"Olsen S. C.","year":"1999","unstructured":"OlsenS. C. BrickerB. PalmerM. V. JensenA. E. ChevilleN. F.. 1999. Responses of cattle to two dosages of Brucella abortus strain RB51: serology, clearance and efficacy. Res. Vet. Sci. 66:101\u2013105.","journal-title":"Res. Vet. Sci."},{"key":"e_1_3_1_18_2","doi-asserted-by":"crossref","first-page":"146","DOI":"10.7589\/0090-3558-33.1.146","article-title":"Bacterial survival, lymph node changes, and immunologic responses of bison (Bison bison) vaccinated with Brucella abortus strain RB51","volume":"33","author":"Olsen S. C.","year":"1997","unstructured":"OlsenS. C. ChevilleN. F. KunkleR. A. PalmerM. V. JensenA. E.. 1997. Bacterial survival, lymph node changes, and immunologic responses of bison (Bison bison) vaccinated with Brucella abortus strain RB51. J. Wildl. Dis. 33:146\u2013151.","journal-title":"J. Wildl. Dis."},{"key":"e_1_3_1_19_2","doi-asserted-by":"crossref","first-page":"410","DOI":"10.2460\/ajvr.1998.59.04.410","article-title":"Vaccination of bison with Brucella abortus strain RB51: Serology, lymphocyte proliferative responses, clearance, and biosafety","volume":"59","author":"Olsen S. C.","year":"1998","unstructured":"OlsenS. C. JensenA. E. PalmerM. V. StevensM. G.. 1998. Vaccination of bison with Brucella abortus strain RB51: Serology, lymphocyte proliferative responses, clearance, and biosafety. Am. J. Vet. Res. 59:410\u2013415.","journal-title":"Am. J. Vet. Res."},{"key":"e_1_3_1_20_2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0034-5288(02)00146-7","article-title":"Efficacy of calfhood vaccination with Brucella abortus strain RB51 in protecting bison against brucellosis","volume":"74","author":"Olsen S. C.","year":"2003","unstructured":"OlsenS. C. JensenA. E. StoffregenW. C. PalmerM. V.. 2003. Efficacy of calfhood vaccination with Brucella abortus strain RB51 in protecting bison against brucellosis. Res. Vet. Sci. 74:17\u201322.","journal-title":"Res. Vet. Sci."},{"key":"e_1_3_1_21_2","doi-asserted-by":"crossref","first-page":"738","DOI":"10.7589\/0090-3558-38.4.738","article-title":"Immune responses of bison to ballistic or hand vaccination with Brucella abortus strain RB51","volume":"38","author":"Olsen S. C.","year":"2002","unstructured":"OlsenS. C. KreegerT. J. SchultzW.. 2002. Immune responses of bison to ballistic or hand vaccination with Brucella abortus strain RB51. J. Wildl. Dis. 38:738\u2013745.","journal-title":"J. Wildl. Dis."},{"key":"e_1_3_1_22_2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.5962\/bhl.title.45792","volume-title":"Some population characteristics of the northern Yellowstone bison herd during the winter of 1988-1989","author":"Pac H. I.","year":"1991","unstructured":"PacH. I. FreyK.. 1991. Some population characteristics of the northern Yellowstone bison herd during the winter of 1988-1989, p. 5\u201311. Montana Department of Fish, Wildlife, and Parks, Bozeman, MT."},{"key":"e_1_3_1_23_2","first-page":"7","volume-title":"Brucellosis in elk and bison in the Greater Yellowstone Area","author":"Ragan V. E.","year":"2002","unstructured":"RaganV. E.. 2002. The brucellosis eradication program in the United States, p. 7\u201315. In KreegerT. J. (ed.), Brucellosis in elk and bison in the Greater Yellowstone Area. Wyoming Game and Fish Department, Laramie, WY."},{"key":"e_1_3_1_24_2","doi-asserted-by":"crossref","first-page":"729","DOI":"10.7589\/0090-3558-45.3.729","article-title":"Pathogenesis and epidemiology of brucellosis in Yellowstone bison: serologic and culture results from adult females and their progeny","volume":"45","author":"Rhyan J. C.","year":"2009","unstructured":"RhyanJ. C.. 2009. Pathogenesis and epidemiology of brucellosis in Yellowstone bison: serologic and culture results from adult females and their progeny. J. Wildl. Dis. 45:729\u2013739.","journal-title":"J. Wildl. Dis."},{"key":"e_1_3_1_25_2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.7589\/0090-3558-37.1.101","article-title":"Pathology of brucellosis in bison from Yellowstone National Park","volume":"37","author":"Rhyan J. C.","year":"2001","unstructured":"RhyanJ. C.. 2001. Pathology of brucellosis in bison from Yellowstone National Park. J. Wildl. Dis. 37:101\u2013109.","journal-title":"J. Wildl. Dis."},{"key":"e_1_3_1_26_2","doi-asserted-by":"crossref","first-page":"950","DOI":"10.2307\/3802809","article-title":"Biosafety of parenteral Brucella abortus RB51 vaccine in bison calves","volume":"63","author":"Roffe T. J.","year":"1999","unstructured":"RoffeT. J.. 1999. Biosafety of parenteral Brucella abortus RB51 vaccine in bison calves. J. Wildl. Mgt. 63:950\u2013955.","journal-title":"J. Wildl. Mgt."},{"key":"e_1_3_1_27_2","doi-asserted-by":"crossref","first-page":"442","DOI":"10.7589\/0090-3558-46.2.442","article-title":"Status of brucellosis in free-ranging elk and bison in Wyoming","volume":"46","author":"Scurlock B. M.","year":"2010","unstructured":"ScurlockB. M. EdwardsW. H.. 2010. Status of brucellosis in free-ranging elk and bison in Wyoming. J. Wildl. Dis. 46:442\u2013449.","journal-title":"J. Wildl. Dis."}],"container-title":["Clinical and Vaccine Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.05383-11","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.05383-11","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T09:41:25Z","timestamp":1713001285000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/CVI.05383-11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":26,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1128\/CVI.05383-11"],"URL":"https:\/\/doi.org\/10.1128\/cvi.05383-11","relation":{},"ISSN":["1556-6811","1556-679X"],"issn-type":[{"value":"1556-6811","type":"print"},{"value":"1556-679X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12]]},"assertion":[{"value":"2011-08-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-09-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-11-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}