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Combining P10 with complete Freund's adjuvant (CFA) or other adjuvants further increases the peptide's antifungal effect. Since dendritic cells (DCs) are up to 1,000-fold more efficient at activating T cells than CFA, we examined the impact of P10-primed bone-marrow-derived DC vaccination in mice. Splenocytes from mice immunized with P10 were stimulated<jats:italic>in vitro<\/jats:italic>with P10 or P10-primed DCs. T cell proliferation was significantly increased in the presence of P10-primed DCs compared to the peptide. The protective efficacy of P10-primed DCs was studied in an intratracheal<jats:named-content content-type=\"genus-species\">P. brasiliensis<\/jats:named-content>model in BALB\/c mice. Administration of P10-primed DCs prior to (via subcutaneous vaccination) or weeks after (via either subcutaneous or intravenous injection)<jats:named-content content-type=\"genus-species\">P. brasiliensis<\/jats:named-content>infection decreased pulmonary damage and significantly reduced fungal burdens. The protective response mediated by the injection of primed DCs was characterized mainly by an increased production of gamma interferon (IFN-\u03b3) and interleukin 12 (IL-12) and a reduction in IL-10 and IL-4 compared to those of infected mice that received saline or unprimed DCs. Hence, our data demonstrate the potential of P10-primed DCs as a vaccine capable of both the rapid protection against the development of serious paracoccidioidomycosis or the treatment of established<jats:named-content content-type=\"genus-species\">P. brasiliensis<\/jats:named-content>disease.<\/jats:p>","DOI":"10.1128\/cvi.05414-11","type":"journal-article","created":{"date-parts":[[2011,11,17]],"date-time":"2011-11-17T12:33:30Z","timestamp":1321533210000},"page":"23-29","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":53,"title":["Prophylactic and Therapeutic Vaccination Using Dendritic Cells Primed with Peptide 10 Derived from the 43-Kilodalton Glycoprotein of Paracoccidioides brasiliensis"],"prefix":"10.1128","volume":"19","author":[{"given":"A.","family":"Magalh\u00e3es","sequence":"first","affiliation":[{"name":"Institute of Biomedical Sciences, Department of Microbiology, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. S.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil; Department of Biological Sciences, Immunology and Parasitology, S\u00e3o Paulo, Brazil; Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. R.","family":"Almeida","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil; Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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