{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T04:00:47Z","timestamp":1770436847132,"version":"3.49.0"},"reference-count":51,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Despite the complexity of tuberculosis (TB) serology, antibodies (Abs) remain attractive biomarkers for TB. Recent evidence of a mycobacterial capsule that consists mainly of the polysaccharides arabinomannan (AM) and glucan provides new options for serologic targets. For this study, Ab responses to AM and glucan for 47 U.S. TB patients (33 HIV negative [HIV\n            <jats:sup>\u2212<\/jats:sup>\n            ], 14 HIV positive [HIV\n            <jats:sup>+<\/jats:sup>\n            ]), 42 healthy controls, and 38 asymptomatic HIV\n            <jats:sup>+<\/jats:sup>\n            controls were evaluated by enzyme-linked immunosorbent assays (ELISAs). The results were compared with Ab responses to the mycobacterial glycolipid cell wall antigen lipoarabinomannan (LAM) and to the proteins malate synthase (MS) and MPT51. We found that the main immunoglobulin (Ig) isotype response to polysaccharides was IgG, predominantly of subclass IgG2. IgG responses to AM were significantly higher for HIV\n            <jats:sup>\u2212<\/jats:sup>\n            and HIV\n            <jats:sup>+<\/jats:sup>\n            TB cases than for controls (\n            <jats:italic>P<\/jats:italic>\n            , &lt;0.0001 and &lt;0.01, respectively); significantly higher for HIV\n            <jats:sup>\u2212<\/jats:sup>\n            than for HIV\n            <jats:sup>+<\/jats:sup>\n            TB cases (\n            <jats:italic>P<\/jats:italic>\n            , &lt;0.01); and significantly higher in sputum smear-positive than smear-negative patients in both HIV\n            <jats:sup>\u2212<\/jats:sup>\n            and HIV\n            <jats:sup>+<\/jats:sup>\n            cases (\n            <jats:italic>P<\/jats:italic>\n            , 0.01 and 0.02, respectively). In both TB groups, titers of Ab to glucan were significantly lower than titers of Ab to AM (\n            <jats:italic>P<\/jats:italic>\n            , &lt;0.0001). IgG responses to AM and MS or to AM and MPT51 did not correlate with each other in HIV\n            <jats:sup>\u2212<\/jats:sup>\n            TB patients, while they correlated significantly in HIV\n            <jats:sup>+<\/jats:sup>\n            TB patients (\n            <jats:italic>P<\/jats:italic>\n            , 0.01 and 0.05, respectively). We conclude that Ab responses to AM could contribute to the serodiagnosis of TB, especially for HIV\n            <jats:sup>\u2212<\/jats:sup>\n            TB patients. This study also provides new and important insights into the differences in the profiles of Abs to mycobacterial antigens between HIV\n            <jats:sup>\u2212<\/jats:sup>\n            and HIV\n            <jats:sup>+<\/jats:sup>\n            TB patients.\n          <\/jats:p>","DOI":"10.1128\/cvi.05550-11","type":"journal-article","created":{"date-parts":[[2011,12,15]],"date-time":"2011-12-15T05:29:42Z","timestamp":1323926982000},"page":"198-208","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":48,"title":["Comparative Evaluation of Profiles of Antibodies to Mycobacterial Capsular Polysaccharides in Tuberculosis Patients and Controls Stratified by HIV Status"],"prefix":"10.1128","volume":"19","author":[{"given":"Xian","family":"Yu","sequence":"first","affiliation":[{"name":"Departments of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Prados-Rosales","sequence":"additional","affiliation":[{"name":"Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth R.","family":"Jenny-Avital","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Sosa","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arturo","family":"Casadevall","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA"},{"name":"Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline M.","family":"Achkar","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"S1179","DOI":"10.1093\/infdis\/jir451","article-title":"Incipient and subclinical tuberculosis: defining early disease states in the context of host immune response","volume":"204","author":"Achkar JM","year":"2011","unstructured":"AchkarJM Jenny-AvitalE. 2011. Incipient and subclinical tuberculosis: defining early disease states in the context of host immune response. J. Infect. Dis. 204:S1179\u2013S1186.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00503-09"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1086\/368096","article-title":"Lipoarabinomannan-reactive human secretory immunoglobulin A responses induced by mucosal bacille Calmette-Guerin vaccination","volume":"187","author":"Brown RM","year":"2003","unstructured":"BrownRM. 2003. Lipoarabinomannan-reactive human secretory immunoglobulin A responses induced by mucosal bacille Calmette-Guerin vaccination. J. Infect. Dis. 187:513\u2013517.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_5_2","first-page":"6234","article-title":"Lipoarabinomannan of Mycobacterium tuberculosis","volume":"267","author":"Chatterjee D","year":"1992","unstructured":"ChatterjeeD LowellK RivoireB McNeilMR BrennanPJ. 1992. Lipoarabinomannan of Mycobacterium tuberculosis. Capping with mannosyl residues in some strains. J. Biol. Chem. 267:6234\u20136239.","journal-title":"Capping with mannosyl residues in some strains. J. Biol. Chem."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.24.1.126-130.1986"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1164\/ajrccm.157.3.9705044","article-title":"Local immune responses correlate with presentation and outcome in tuberculosis","volume":"157","author":"Condos R","year":"1998","unstructured":"CondosR RomWN LiuYM SchlugerNW. 1998. Local immune responses correlate with presentation and outcome in tuberculosis. Am. J. Respir. Crit. Care Med. 157:729\u2013735.","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1365-2249.1993.tb03348.x","article-title":"Immunoglobulin G subclass responses to mycobacterial lipoarabinomannan in HIV-infected and non-infected patients with tuberculosis","volume":"91","author":"Da Costa CT","year":"1993","unstructured":"Da CostaCT Khanolkar-YoungS ElliottAM WasunnaKM McAdamKP. 1993. Immunoglobulin G subclass responses to mycobacterial lipoarabinomannan in HIV-infected and non-infected patients with tuberculosis. Clin. Exp. Immunol. 91:25\u201329.","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1054\/tuld.1998.0200","article-title":"The capsule of Mycobacterium tuberculosis and its implications for pathogenicity","volume":"79","author":"Daff\u00e9 M","year":"1999","unstructured":"Daff\u00e9M EtienneG. 1999. The capsule of Mycobacterium tuberculosis and its implications for pathogenicity. Tuber. Lung Dis. 79:153\u2013169.","journal-title":"Tuber. Lung Dis."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.10.6846-6851.2005"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1995.tb05568.x"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1365-2249.1992.tb03069.x","article-title":"Specificity of IgG subclass antibodies in different clinical manifestations of leprosy","volume":"88","author":"Dhandayuthapani S","year":"1992","unstructured":"DhandayuthapaniS IzumiS AnandanD BhatiaVN. 1992. Specificity of IgG subclass antibodies in different clinical manifestations of leprosy. Clin. Exp. Immunol. 88:253\u2013257.","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1093\/glycob\/cwn031","article-title":"Comparative structural analyses of the alpha-glucan and glycogen from Mycobacterium bovis","volume":"18","author":"Dinadayala P","year":"2008","unstructured":"DinadayalaP SambouT Daff\u00e9M LemassuA. 2008. Comparative structural analyses of the alpha-glucan and glycogen from Mycobacterium bovis. Glycobiology 18:502\u2013508.","journal-title":"Glycobiology"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1111\/j.1462-5822.2007.00940.x","article-title":"Cell wall-associated alpha-glucan is instrumental for Mycobacterium tuberculosis to block CD1 molecule expression and disable the function of dendritic cell derived from infected monocyte","volume":"9","author":"Gagliardi MC","year":"2007","unstructured":"GagliardiMC. 2007. Cell wall-associated alpha-glucan is instrumental for Mycobacterium tuberculosis to block CD1 molecule expression and disable the function of dendritic cell derived from infected monocyte. Cell. Microbiol. 9:2081\u20132092.","journal-title":"Cell. Microbiol."},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.tube.2006.01.008","article-title":"The role of antibody-mediated immunity in defense against Mycobacterium tuberculosis: advances toward a novel vaccine strategy","volume":"86","author":"Glatman-Freedman A","year":"2006","unstructured":"Glatman-FreedmanA. 2006. The role of antibody-mediated immunity in defense against Mycobacterium tuberculosis: advances toward a novel vaccine strategy. Tuberculosis (Edinb.) 86:191\u2013197.","journal-title":"Tuberculosis (Edinb.)"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.7.3225-3231.2004"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.6.1989-1993.2002"},{"key":"e_1_3_2_18_2","first-page":"30635","article-title":"Structural study of lipomannan and lipoarabinomannan from Mycobacterium chelonae. Presence of unusual components with \u03b11,3-mannopyranose side chains","volume":"277","author":"Guerardel Y","year":"2002","unstructured":"GuerardelY. 2002. Structural study of lipomannan and lipoarabinomannan from Mycobacterium chelonae. Presence of unusual components with \u03b11,3-mannopyranose side chains. J. Biol. Chem. 277:30635\u201330648.","journal-title":"J. Biol. Chem."},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","first-page":"4081","DOI":"10.1016\/S0264-410X(03)00274-3","article-title":"Mycobacterium tuberculosis arabinomannan-protein conjugates protect against tuberculosis","volume":"21","author":"Hamasur B","year":"2003","unstructured":"HamasurB. 2003. Mycobacterium tuberculosis arabinomannan-protein conjugates protect against tuberculosis. Vaccine 21:4081\u20134093.","journal-title":"Vaccine"},{"key":"e_1_3_2_20_2","first-page":"211","article-title":"Predominance of the IgG1 subclass in the hypergammaglobulinemia observed in pre-AIDS and AIDS","volume":"12","author":"Kekow J","year":"1988","unstructured":"KekowJ HobuschG GrossWL. 1988. Predominance of the IgG1 subclass in the hypergammaglobulinemia observed in pre-AIDS and AIDS. Cancer Detect. Prev. 12:211\u2013216.","journal-title":"Cancer Detect. Prev."},{"key":"e_1_3_2_21_2","doi-asserted-by":"crossref","first-page":"12380","DOI":"10.1074\/jbc.270.21.12380","article-title":"Inositol phosphate capping of the nonreducing termini of lipoarabinomannan from rapidly growing strains of Mycobacterium","volume":"270","author":"Khoo KH","year":"1995","unstructured":"KhooKH DellA MorrisHR BrennanPJ ChatterjeeD. 1995. Inositol phosphate capping of the nonreducing termini of lipoarabinomannan from rapidly growing strains of Mycobacterium. J. Biol. Chem. 270:12380\u201312389.","journal-title":"J. Biol. Chem."},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"14703","DOI":"10.1073\/pnas.1009080107","article-title":"Dynamic antibody responses to the Mycobacterium tuberculosis proteome","volume":"107","author":"Kunnath-Velayudhan S","year":"2010","unstructured":"Kunnath-VelayudhanS. 2010. Dynamic antibody responses to the Mycobacterium tuberculosis proteome. Proc. Natl. Acad. Sci. U. S. A. 107:14703\u201314708.","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"e_1_3_2_23_2","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1056\/NEJM198308253090803","article-title":"Abnormalities of B-cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome","volume":"309","author":"Lane HC","year":"1983","unstructured":"LaneHC. 1983. Abnormalities of B-cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome. N. Engl. J. Med. 309:453\u2013458.","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"e_1_3_2_24_2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1042\/bj2970351","article-title":"Structural features of the exocellular polysaccharides of Mycobacterium tuberculosis","volume":"297","author":"Lemassu A","year":"1994","unstructured":"LemassuA Daff\u00e9M. 1994. Structural features of the exocellular polysaccharides of Mycobacterium tuberculosis. Biochem. J. 297(Pt 2):351\u2013357.","journal-title":"Biochem. J."},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.8.3936-3940.1998"},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","first-page":"857","DOI":"10.2217\/fmb.09.58","article-title":"Genetic diversity of the pneumococcal capsule: implications for molecular-based serotyping","volume":"4","author":"McEllistrem MC","year":"2009","unstructured":"McEllistremMC. 2009. Genetic diversity of the pneumococcal capsule: implications for molecular-based serotyping. Future Microbiol. 4:857\u2013865.","journal-title":"Future Microbiol."},{"key":"e_1_3_2_27_2","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0140-6736(11)60005-6","article-title":"WHO recommends against inaccurate tuberculosis tests","volume":"377","author":"Morris K","year":"2011","unstructured":"MorrisK. 2011. WHO recommends against inaccurate tuberculosis tests. Lancet 377:113\u2013114.","journal-title":"Lancet"},{"key":"e_1_3_2_28_2","first-page":"88","article-title":"Specificity and diversity of antibodies to Mycobacterium tuberculosis arabinomannan","volume":"10","author":"Navoa JA","year":"2003","unstructured":"NavoaJA. 2003. Specificity and diversity of antibodies to Mycobacterium tuberculosis arabinomannan. Clin. Diagn. Lab. Immunol. 10:88\u201394.","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.17.1.218-234.2004"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00067-09"},{"key":"e_1_3_2_31_2","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1172\/JCI44261","article-title":"Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice","volume":"121","author":"Prados-Rosales R","year":"2011","unstructured":"Prados-RosalesR. 2011. Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice. J. Clin. Invest. 121:1471\u20131483.","journal-title":"J. Clin. Invest."},{"key":"e_1_3_2_32_2","first-page":"383","article-title":"Natural infection of man with group A streptococci","volume":"5","author":"Riesen WF","year":"1976","unstructured":"RiesenWF SkvarilF BraunDG. 1976. Natural infection of man with group A streptococci. Levels; restriction in class, subclass, and type; and clonal appearance of polysaccharide-group-specific antibodies. Scand. J. Immunol. 5:383\u2013390.","journal-title":"Levels; restriction in class, subclass, and type; and clonal appearance of polysaccharide-group-specific antibodies. Scand. J. Immunol."},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00602-06"},{"key":"e_1_3_2_34_2","doi-asserted-by":"crossref","first-page":"4600","DOI":"10.1128\/IAI.69.7.4600-4609.2001","article-title":"Homogeneity of antibody responses in tuberculosis patients","volume":"69","author":"Samanich K","year":"2001","unstructured":"SamanichK BelisleJT LaalS. 2001. Homogeneity of antibody responses in tuberculosis patients. Infect. Immun. 69:4600\u20134609.","journal-title":"Infect. Immun."},{"key":"e_1_3_2_35_2","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1086\/314438","article-title":"Delineation of human antibody responses to culture filtrate antigens of Mycobacterium tuberculosis","volume":"178","author":"Samanich KM","year":"1998","unstructured":"SamanichKM. 1998. Delineation of human antibody responses to culture filtrate antigens of Mycobacterium tuberculosis. J. Infect. Dis. 178:1534\u20131538.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.7.4.662-668.2000"},{"key":"e_1_3_2_37_2","doi-asserted-by":"crossref","first-page":"e1000794","DOI":"10.1371\/journal.ppat.1000794","article-title":"Direct visualization by cryo-EM of the mycobacterial capsular layer: a labile structure containing ESX-1-secreted proteins","volume":"6","author":"Sani M","year":"2010","unstructured":"SaniM. 2010. Direct visualization by cryo-EM of the mycobacterial capsular layer: a labile structure containing ESX-1-secreted proteins. PLoS Pathog. 6:e1000794.","journal-title":"PLoS Pathog."},{"key":"e_1_3_2_38_2","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1074\/mcp.M600089-MCP200","article-title":"Disease state differentiation and identification of tuberculosis biomarkers via native antigen array profiling","volume":"5","author":"Sartain MJ","year":"2006","unstructured":"SartainMJ SlaydenRA SinghKK LaalS BelisleJT. 2006. Disease state differentiation and identification of tuberculosis biomarkers via native antigen array profiling. Mol. Cell. Proteomics 5:2102\u20132113.","journal-title":"Mol. Cell. Proteomics"},{"key":"e_1_3_2_39_2","unstructured":"SchwebachJR. 2002. The carbohydrate surface of M. tuberculosis: antigenicity and antibody immunity. Ph.D. thesis. Albert Einstein College of Medicine Bronx New York."},{"key":"e_1_3_2_40_2","doi-asserted-by":"crossref","first-page":"5671","DOI":"10.1128\/IAI.69.9.5671-5678.2001","article-title":"Expression of a Mycobacterium tuberculosis arabinomannan antigen in vitro and in vivo","volume":"69","author":"Schwebach JR","year":"2001","unstructured":"SchwebachJR. 2001. Expression of a Mycobacterium tuberculosis arabinomannan antigen in vitro and in vivo. Infect. Immun. 69:5671\u20135678.","journal-title":"Infect. Immun."},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.5.2566-2575.2002"},{"key":"e_1_3_2_42_2","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1056\/NEJM198007243030402","article-title":"Correlation between serum IgG-2 concentrations and the antibody response to bacterial polysaccharide antigens","volume":"303","author":"Siber GR","year":"1980","unstructured":"SiberGR SchurPH AisenbergAC WeitzmanSA SchiffmanG. 1980. Correlation between serum IgG-2 concentrations and the antibody response to bacterial polysaccharide antigens. N. Engl. J. Med. 303:178\u2013182.","journal-title":"N. Engl. J. Med."},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00325-10"},{"key":"e_1_3_2_44_2","first-page":"134","article-title":"IgG subclasses in viral infections","volume":"19","author":"Skvaril F","year":"1986","unstructured":"SkvarilF. 1986. IgG subclasses in viral infections. Monogr. Allergy 19:134\u2013143.","journal-title":"Monogr. Allergy"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00355-08"},{"key":"e_1_3_2_46_2","doi-asserted-by":"crossref","first-page":"e202","DOI":"10.1371\/journal.pmed.0040202","article-title":"Commercial serological antibody detection tests for the diagnosis of pulmonary tuberculosis: a systematic review","volume":"4","author":"Steingart KR","year":"2007","unstructured":"SteingartKR. 2007. Commercial serological antibody detection tests for the diagnosis of pulmonary tuberculosis: a systematic review. PLoS Med. 4:e202.","journal-title":"PLoS Med."},{"key":"e_1_3_2_47_2","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1136\/thx.2006.075754","article-title":"A systematic review of commercial serological antibody detection tests for the diagnosis of extrapulmonary tuberculosis","volume":"83","author":"Steingart KR","year":"2007","unstructured":"SteingartKR. 2007. A systematic review of commercial serological antibody detection tests for the diagnosis of extrapulmonary tuberculosis. Postgrad. Med. J. 83:705\u2013712.","journal-title":"Postgrad. Med. J."},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.10.5676-5686.2004"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.3.2100"},{"key":"e_1_3_2_50_2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/00365540110077263","article-title":"Circulating antibodies to lipoarabinomannan in relation to sputum microscopy, clinical features and urinary anti-lipoarabinomannan detection in pulmonary tuberculosis","volume":"34","author":"Tessema TA","year":"2002","unstructured":"TessemaTA. 2002. Circulating antibodies to lipoarabinomannan in relation to sputum microscopy, clinical features and urinary anti-lipoarabinomannan detection in pulmonary tuberculosis. Scand. J. Infect. Dis. 34:97\u2013103.","journal-title":"Scand. J. Infect. Dis."},{"key":"e_1_3_2_51_2","doi-asserted-by":"crossref","first-page":"e2071","DOI":"10.1371\/journal.pone.0002071","article-title":"Biomarkers for clinical and incipient tuberculosis: performance in a TB-endemic country","volume":"3","author":"Wanchu A","year":"2008","unstructured":"WanchuA. 2008. Biomarkers for clinical and incipient tuberculosis: performance in a TB-endemic country. PLoS One 3:e2071.","journal-title":"PLoS One"},{"key":"e_1_3_2_52_2","unstructured":"World Health Organization. 2008. Laboratory-based evaluation of 19 commercially available rapid diagnostic tests for tuberculosis. World Health Organization on behalf of the Special Programme for Research and Training in Tropical Diseases Geneva Switzerland."}],"container-title":["Clinical and Vaccine Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.05550-11","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CVI.05550-11","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T20:46:56Z","timestamp":1627591616000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/CVI.05550-11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1128\/CVI.05550-11"],"URL":"https:\/\/doi.org\/10.1128\/cvi.05550-11","relation":{},"ISSN":["1556-6811","1556-679X"],"issn-type":[{"value":"1556-6811","type":"print"},{"value":"1556-679X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2]]},"assertion":[{"value":"2011-10-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-12-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-01-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}