{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:33:34Z","timestamp":1787016814184,"version":"build-2736575974"},"reference-count":25,"publisher":"American Society for Microbiology","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin. Vaccine Immunol."],"published-print":{"date-parts":[[2012,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n Anti-\n Mycobacterium tuberculosis<\/jats:named-content>\n IgG antibodies may aid in the diagnosis of active\n M. tuberculosis<\/jats:named-content>\n disease. We studied whether anti-\n M. tuberculosis<\/jats:named-content>\n IgG antibodies are elevated in active\n M. tuberculosis<\/jats:named-content>\n disease and assessed factors contributing to false-positive and -negative results. A retrospective study of 2,150 individuals tested by the QuantiFERON-TB Gold In-Tube (QFT-GIT) assay was conducted at the University of Utah, ARUP Laboratories, November 2008 to December 2010. All samples were tested with the InBios Active Tb\n Detect<\/jats:italic>\n antituberculosis (anti-TB) IgG antibody assay. Of 1,044 patients with a positive QFT-GIT, 59 (5.7%) were positive for\n M. tuberculosis<\/jats:named-content>\n antibodies. Fourteen of 1,106 (1.3%) with a negative or indeterminate QFT-GIT were positive for\n M. tuberculosis<\/jats:named-content>\n antibodies.\n M. tuberculosis<\/jats:named-content>\n antibody tests were positive in 61.5% with confirmed active\n M. tuberculosis<\/jats:named-content>\n disease and other mycobacterial infections. Over half of the false-negative\n M. tuberculosis<\/jats:named-content>\n antibody tests occurred in patients \u226590 years of age. False positives were seen in 12.9% of autoimmune patients. The odds ratio of being positive by the QFT-GIT and the InBios TB IgG assay increased with confirmed\n M. tuberculosis<\/jats:named-content>\n disease or highly suspected\n M. tuberculosis<\/jats:named-content>\n disease and was 86.7 (95% confidence interval [CI], 34.4 to 218.5) in these two groups compared to patients negative by both tests. Although anti-\n M. tuberculosis<\/jats:named-content>\n antibodies can be detected in patients with active\n M. tuberculosis<\/jats:named-content>\n disease, caution should be used with patients where immunoglobulin levels may be decreased or patients with autoantibodies.\n <\/jats:p>","DOI":"10.1128\/cvi.05573-11","type":"journal-article","created":{"date-parts":[[2012,2,2]],"date-time":"2012-02-02T14:54:14Z","timestamp":1328194454000},"page":"522-526","source":"Crossref","is-referenced-by-count":19,"title":["Antituberculosis IgG Antibodies as a Marker of Active Mycobacterium tuberculosis Disease"],"prefix":"10.1128","volume":"19","author":[{"given":"Ryan J.","family":"Welch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"Lawless","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"Litwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","published-online":{"date-parts":[[2012,2,1]]},"reference":[{"key":"key20180919073601_B1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1365-2249.2009.03967.x","article-title":"The protective role of antibody responses during Mycobacterium tuberculosis infection","volume":"157","author":"Abebe","year":"2009","journal-title":"Clin. 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