{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:20:51Z","timestamp":1760984451906},"reference-count":40,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            A prospective clinical cohort study was established to investigate the humoral immune response in middle ear fluids (MEF) and serum against bacterial surface proteins in children suffering from recurrent acute otitis media (rAOM) and chronic otitis media with effusion (COME), using Luminex xMAP technology. The association between the humoral immune response and the presence of\n            <jats:named-content content-type=\"genus-species\">Moraxella catarrhalis<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">Streptococcus pneumoniae<\/jats:named-content>\n            in the nasopharynx and middle ear was also studied. The levels of antigen-specific IgG, IgA, and IgM showed extensive interindividual variation. No significant differences in anti-\n            <jats:named-content content-type=\"genus-species\">M. catarrhalis<\/jats:named-content>\n            and anti-\n            <jats:named-content content-type=\"genus-species\">S. pneumoniae<\/jats:named-content>\n            serum and MEF median fluorescence intensity (MFI) values (anti-\n            <jats:named-content content-type=\"genus-species\">M. catarrhalis<\/jats:named-content>\n            and antipneumococcal IgG levels) were observed between the rAOM or COME groups for all antigens tested. No significant differences were observed for\n            <jats:named-content content-type=\"genus-species\">M. catarrhalis<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">S. pneumoniae<\/jats:named-content>\n            colonization and serum IgG levels against the\n            <jats:named-content content-type=\"genus-species\">Moraxella<\/jats:named-content>\n            and pneumococcal antigens. Similar to the antibody response in serum, no significant differences in IgG, IgA, and IgM levels in MEF were observed for all\n            <jats:named-content content-type=\"genus-species\">M. catarrhalis<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">S. pneumoniae<\/jats:named-content>\n            antigens between OM\n            <jats:named-content content-type=\"genus-species\">M. catarrhalis-<\/jats:named-content>\n            or\n            <jats:named-content content-type=\"genus-species\">S. pneumoniae<\/jats:named-content>\n            -positive and OM\n            <jats:named-content content-type=\"genus-species\">M. catarrhalis-<\/jats:named-content>\n            or\n            <jats:named-content content-type=\"genus-species\">S. pneumonia<\/jats:named-content>\n            -negative children suffering from either rAOM or COME. Finally, results indicated a strong correlation between antigen-specific serum and MEF IgG levels. We observed no significant\n            <jats:italic>in vivo<\/jats:italic>\n            expressed anti-\n            <jats:named-content content-type=\"genus-species\">M. catarrhalis<\/jats:named-content>\n            or anti-\n            <jats:named-content content-type=\"genus-species\">S. pneumoniae<\/jats:named-content>\n            humoral immune responses using a range of putative vaccine candidate proteins. Other factors, such as Eustachian tube dysfunction, viral load, and genetic and environmental factors, may play a more important role in the pathogenesis of OM and in particular in the development of rAOM or COME.\n          <\/jats:p>","DOI":"10.1128\/cvi.05630-11","type":"journal-article","created":{"date-parts":[[2012,4,27]],"date-time":"2012-04-27T00:39:40Z","timestamp":1335487180000},"page":"914-918","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":11,"title":["Comparative Analysis of the Humoral Immune Response to Moraxella catarrhalis and Streptococcus pneumoniae Surface Antigens in Children Suffering from Recurrent Acute Otitis Media and Chronic Otitis Media with Effusion"],"prefix":"10.1128","volume":"19","author":[{"given":"Suzanne J. 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