{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T20:01:07Z","timestamp":1774382467594,"version":"3.50.1"},"reference-count":72,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Eosinophil activity in vivo and in vitro was studied in relation to infection intensities and plasma cytokine profiles of 51<jats:italic>Schistosoma mansoni<\/jats:italic>-infected Ugandan fishermen before treatment and 24 h and 3 weeks posttreatment. Blood eosinophil numbers significantly declined 24 h posttreatment, but significant eosinophilia had developed by 3 weeks posttreatment. Cellular eosinophil cationic protein (ECP) content increased significantly during the transient eosinopenia but was significantly reduced 3 weeks later. No similar reduction in cellular eosinophil protein X (EPX) content was seen. Before treatment,<jats:italic>S. mansoni<\/jats:italic>infection intensity was positively correlated with 24-h boosts in plasma interleukin-5 (IL-5) and IL-6 levels, which were in turn negatively correlated with the posttreatment fall in eosinophil numbers. Significant correlations were observed between pretreatment infection intensities and plasma IL-10 and eotaxin levels. Treatment induced significant fluctuations in plasma IL-5, IL-6, IL-10, tumor necrosis factor alpha (TNF-\u03b1), and eotaxin levels. Optimal relative release of ECP and EPX in vitro was detected in<jats:italic>S. mansoni<\/jats:italic>soluble egg antigen-stimulated cultures during transient eosinopenia. Our data suggest that blood eosinophils are activated during<jats:italic>S. mansoni<\/jats:italic>infection and that treatment induces a burst in released antigens, causing increased production of IL-5, IL-6, IL-10, and eotaxin; a drop in TNF-\u03b1 levels; and a transient sequestration of eosinophils, which leaves fewer degranulated eosinophils in the circulation 24 h posttreatment, followed by the development of eosinophilia 3 weeks later. During these events, it appears that preferential release of ECP occurs in vivo. Moreover, it is possible that infection intensity-dependent levels of plasma IL-10 may be involved in the prevention of treatment-induced anaphylactic reactions.<\/jats:p>","DOI":"10.1128\/cvi.13.5.584-593.2006","type":"journal-article","created":{"date-parts":[[2006,5,8]],"date-time":"2006-05-08T22:09:23Z","timestamp":1147126163000},"page":"584-593","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["Eosinophil Activity in<i>Schistosoma mansoni<\/i>Infections In Vivo and In Vitro in Relation to Plasma Cytokine Profile Pre- and Posttreatment with Praziquantel"],"prefix":"10.1128","volume":"13","author":[{"given":"Claus M.","family":"Reimert","sequence":"first","affiliation":[{"name":"DBL, Institute for Health Research and Development, Charlottenlund, Denmark"},{"name":"Department of Pathology, University of Cambridge, Cambridge, United Kingdom"},{"name":"Kenya Medical Research Institute, Nairobi, 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Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph K.","family":"Mwatha","sequence":"additional","affiliation":[{"name":"DBL, Institute for Health Research and Development, Charlottenlund, Denmark"},{"name":"Department of Pathology, University of Cambridge, Cambridge, United Kingdom"},{"name":"Kenya Medical Research Institute, Nairobi, Kenya"},{"name":"Vector Control Division, Ugandan Ministry of Health, Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frances M.","family":"Jones","sequence":"additional","affiliation":[{"name":"DBL, Institute for Health Research and Development, Charlottenlund, Denmark"},{"name":"Department of Pathology, University of Cambridge, Cambridge, United Kingdom"},{"name":"Kenya Medical Research Institute, Nairobi, Kenya"},{"name":"Vector Control Division, Ugandan Ministry of Health, Kampala, 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Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Booth","sequence":"additional","affiliation":[{"name":"DBL, Institute for Health Research and Development, Charlottenlund, Denmark"},{"name":"Department of Pathology, University of Cambridge, Cambridge, United Kingdom"},{"name":"Kenya Medical Research Institute, Nairobi, Kenya"},{"name":"Vector Control Division, Ugandan Ministry of Health, Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narcis B.","family":"Kabatereine","sequence":"additional","affiliation":[{"name":"DBL, Institute for Health Research and Development, Charlottenlund, Denmark"},{"name":"Department of Pathology, University of Cambridge, Cambridge, United Kingdom"},{"name":"Kenya Medical Research Institute, Nairobi, Kenya"},{"name":"Vector Control Division, Ugandan Ministry of Health, Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David 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