{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T22:07:02Z","timestamp":1772489222528,"version":"3.50.1"},"reference-count":66,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Eukaryot Cell"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content content-type=\"genus-species\">Aspergillus fumigatus<\/jats:named-content>\n            is a major opportunistic pathogen and allergen of mammals. Nutrient sensing and acquisition mechanisms, as well as the capability to cope with different stressing conditions, are essential for\n            <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n            virulence and survival in the mammalian host. This study characterized the\n            <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n            SebA transcription factor, which is the putative homologue of the factor encoded by\n            <jats:named-content content-type=\"genus-species\">Trichoderma atroviride<\/jats:named-content>\n            <jats:italic>seb1<\/jats:italic>\n            . The \u0394\n            <jats:italic>sebA<\/jats:italic>\n            mutant demonstrated reduced growth in the presence of paraquat, hydrogen peroxide, CaCl\n            <jats:sub>2<\/jats:sub>\n            , and poor nutritional conditions, while viability associated with\n            <jats:italic>sebA<\/jats:italic>\n            was also affected by heat shock exposure. Accordingly, SebA::GFP (SebA::green fluorescent protein) was shown to accumulate in the nucleus upon exposure to oxidative stress and heat shock conditions. In addition, genes involved in either the oxidative stress or heat shock response had reduced transcription in the \u0394\n            <jats:italic>sebA<\/jats:italic>\n            mutant. The\n            <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n            \u0394\n            <jats:italic>sebA<\/jats:italic>\n            strain was attenuated in virulence in a murine model of invasive pulmonary aspergillosis. Furthermore, killing of the \u0394\n            <jats:italic>sebA<\/jats:italic>\n            mutant by murine alveolar macrophages was increased compared to killing of the wild-type strain.\n            <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n            SebA plays a complex role, contributing to several stress tolerance pathways and growth under poor nutritional conditions, and seems to be integrated into different stress responses.\n          <\/jats:p>","DOI":"10.1128\/ec.00016-12","type":"journal-article","created":{"date-parts":[[2012,2,18]],"date-time":"2012-02-18T05:08:16Z","timestamp":1329541696000},"page":"518-531","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":40,"title":["Molecular Characterization of the Putative Transcription Factor SebA Involved in Virulence in Aspergillus fumigatus"],"prefix":"10.1128","volume":"11","author":[{"given":"Ta\u00edsa Magnani","family":"Dinamarco","sequence":"first","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo S.","family":"Almeida","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia","family":"Alves de Castro","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil Andrew","family":"Brown","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thaila Fernanda","family":"dos Reis","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandra Naira","family":"Zambelli Ramalho","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Savoldi","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Helena S.","family":"Goldman","sequence":"additional","affiliation":[{"name":"Faculdade de Filosofia, Ci\u00eancias e Letras de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo Henrique","family":"Goldman","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Nacional de Ci\u00eancia e Tecnologia do Bioetanol\u2014CTBE, S\u00e3o Paulo, Brazil"},{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-11-32"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1578"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2009.07.002"},{"key":"e_1_3_3_5_2","first-page":"137","article-title":"Mycological control and surveillance of biological waste and compost","volume":"36","author":"Beffa T","year":"1998","unstructured":"BeffaT. 1998. 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