{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:58:57Z","timestamp":1791097137584,"version":"4.1.0"},"reference-count":206,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Eukaryot Cell"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Opportunistic pathogens have become of increasing medical importance over the last decade due to the AIDS pandemic. Not only is cryptococcosis the fourth-most-common fatal infectious disease in sub-Saharan Africa, but also\n                    <jats:named-content content-type=\"genus-species\">Cryptococcus<\/jats:named-content>\n                    is an emerging pathogen of immunocompetent individuals. The interaction between\n                    <jats:named-content content-type=\"genus-species\">Cryptococcus<\/jats:named-content>\n                    and the host's immune system is a major determinant for the outcome of disease. Despite initial infection in early childhood with\n                    <jats:named-content content-type=\"genus-species\">Cryptococcus neoformans<\/jats:named-content>\n                    and frequent exposure to\n                    <jats:named-content content-type=\"genus-species\">C. neoformans<\/jats:named-content>\n                    within the environment, immunocompetent individuals are generally able to contain the fungus or maintain the yeast in a latent state. However, immune deficiencies lead to disseminating infections that are uniformly fatal without rapid clinical intervention. This review will discuss the innate and adaptive immune responses to\n                    <jats:named-content content-type=\"genus-species\">Cryptococcus<\/jats:named-content>\n                    and cryptococcal strategies to evade the host's defense mechanisms. It will also address the importance of these strategies in pathogenesis and the potential of immunotherapy in cryptococcosis treatment.\n                  <\/jats:p>","DOI":"10.1128\/ec.00039-10","type":"journal-article","created":{"date-parts":[[2010,4,9]],"date-time":"2010-04-09T21:09:42Z","timestamp":1270847382000},"page":"835-846","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":179,"title":["Cryptococcal Interactions with the Host Immune System"],"prefix":"10.1128","volume":"9","author":[{"given":"Kerstin","family":"Voelz","sequence":"first","affiliation":[{"name":"School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin C.","family":"May","sequence":"additional","affiliation":[{"name":"School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/314953"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.10.5794-5802.2003"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042560-200004010-00001"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2006.09.061"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-8-16"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2008.01152.x"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.10.6346"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-196112000-00015"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-196105000-00009"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-196307000-00007"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.1.158"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.10.6445-6455.2001"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2003-0156OC"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/02681218980000291"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.94.5.1480-1483.1967"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.11.1.73-79.1975"},{"key":"e_1_3_1_18_2","first-page":"236","article-title":"Primary pulmonary cryptococcosis","volume":"94","author":"Campbell G. D","year":"1966","unstructured":"Campbell G. D . 1966. Primary pulmonary cryptococcosis. Am. Rev. Respir. Dis.94:236\u2013243.","journal-title":"Am. Rev. Respir. Dis."},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.2174\/1566524054022567"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.14.7.4912-4919.1994"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01065-08"},{"key":"e_1_3_1_22_2","doi-asserted-by":"crossref","first-page":"3836","DOI":"10.4049\/jimmunol.156.10.3836","article-title":"Oxidative killing of Cryptococcus neoformans by human neutrophils. Evidence that fungal mannitol protects by scavenging reactive oxygen intermediates","volume":"156","author":"Chaturvedi V.","year":"1996","unstructured":"Chaturvedi V. Wong B. Newman S. L. . 1996. Oxidative killing of Cryptococcus neoformans by human neutrophils. Evidence that fungal mannitol protects by scavenging reactive oxygen intermediates. J. Immunol.156:3836\u20133840.","journal-title":"J. Immunol."},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1086\/341564"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.3.686-689.2001"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.1.173-180.2003"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2001.02236.x"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.2.443-448.2000"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1997.00238.x"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.1.383"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M806473200"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/145.6.870"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.10.4994-5000.1998"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2003.10.029"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.3.5.1067-1075.2004"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0264-410X(95)00256-Z"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.59.10.3700-3707.1991"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.38.1.380-382.1982"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-144-37580"},{"key":"e_1_3_1_39_2","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.4049\/jimmunol.112.6.2260","article-title":"The role of the classical and alternate complement pathways in host defenses against Cryptococcus neoformans infection","volume":"112","author":"Diamond R. D.","year":"1974","unstructured":"Diamond R. D. May J. E. Kane M. A. Frank M. M. Bennett J. E. . 1974. The role of the classical and alternate complement pathways in host defenses against Cryptococcus neoformans infection. J. Immunol.112:2260\u20132270.","journal-title":"J. Immunol."},{"key":"e_1_3_1_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/125.4.367"},{"key":"e_1_3_1_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.2.557-563.1997"},{"key":"e_1_3_1_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.55.3.749-752.1987"},{"key":"e_1_3_1_43_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040021"},{"key":"e_1_3_1_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.60.8.3446-3447.1992"},{"key":"e_1_3_1_45_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.12.7102"},{"key":"e_1_3_1_46_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-147-8-2355"},{"key":"e_1_3_1_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.7.4225-4237.2000"},{"key":"e_1_3_1_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.3.1571-1580.2002"},{"key":"e_1_3_1_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(01)02035-2"},{"key":"e_1_3_1_50_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R100022200"},{"key":"e_1_3_1_51_2","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.4049\/jimmunol.142.9.3219","article-title":"Fungicidal activity of IFN-gamma-activated macrophages. Extracellular killing of Cryptococcus neoformans","volume":"142","author":"Flesch I. E.","year":"1989","unstructured":"Flesch I. E. Schwamberger G. Kaufmann S. H. . 1989. Fungicidal activity of IFN-gamma-activated macrophages. Extracellular killing of Cryptococcus neoformans. J. Immunol.142:3219\u20133224.","journal-title":"J. Immunol."},{"key":"e_1_3_1_52_2","doi-asserted-by":"publisher","DOI":"10.1086\/315102"},{"key":"e_1_3_1_53_2","doi-asserted-by":"publisher","DOI":"10.1086\/515688"},{"key":"e_1_3_1_54_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI13407"},{"key":"e_1_3_1_55_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/116.5.551"},{"key":"e_1_3_1_56_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.10.3204-3209.1999"},{"key":"e_1_3_1_57_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01213-05"},{"key":"e_1_3_1_58_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.13.1.122"},{"key":"e_1_3_1_59_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.5.e66"},{"key":"e_1_3_1_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri978"},{"key":"e_1_3_1_61_2","first-page":"508","article-title":"Virulence of Cryptococcus neoformans","volume":"76","author":"Granger D. L.","year":"1985","unstructured":"Granger D. L. Perfect J. R. Durack D. T. . 1985. Virulence of Cryptococcus neoformans. Regulation of capsule synthesis by carbon dioxide. J. Clin. Invest.76:508\u2013516.","journal-title":"Regulation of capsule synthesis by carbon dioxide. J. Clin. Invest."},{"key":"e_1_3_1_62_2","doi-asserted-by":"publisher","DOI":"10.1080\/00362178185380411"},{"key":"e_1_3_1_63_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.6.3853"},{"key":"e_1_3_1_64_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01049-09"},{"key":"e_1_3_1_65_2","doi-asserted-by":"publisher","DOI":"10.1053\/jinf.2000.0695"},{"key":"e_1_3_1_66_2","doi-asserted-by":"publisher","DOI":"10.1080\/00362177085190391"},{"key":"e_1_3_1_67_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.11.6533"},{"key":"e_1_3_1_68_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M312995200"},{"key":"e_1_3_1_69_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.17.6.2879"},{"key":"e_1_3_1_70_2","doi-asserted-by":"publisher","DOI":"10.1128\/aem.62.9.3158-3164.1996"},{"key":"e_1_3_1_71_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.158.6.2108"},{"key":"e_1_3_1_72_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.7.2857-2864.1994"},{"key":"e_1_3_1_73_2","doi-asserted-by":"publisher","DOI":"10.1159\/000109193"},{"key":"e_1_3_1_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1245"},{"key":"e_1_3_1_75_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/116.1.75"},{"key":"e_1_3_1_76_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.2.896-903.2006"},{"key":"e_1_3_1_77_2","unstructured":"Janeway C. A. Travers P. Walport M. Shlomchik M. . 2001. Immunobiology: the immune system in health and disease 5th ed.Garland Science London England."},{"key":"e_1_3_1_78_2","first-page":"137","article-title":"Regulation by innate immune T lymphocytes in the host defense against pulmonary infection with Cryptococcus neoformans","volume":"57","author":"Kawakami K","year":"2004","unstructured":"Kawakami K . 2004. Regulation by innate immune T lymphocytes in the host defense against pulmonary infection with Cryptococcus neoformans. Jpn. J. Infect. Dis.57:137\u2013145.","journal-title":"Jpn. J. Infect. Dis."},{"key":"e_1_3_1_79_2","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.1999.1557"},{"key":"e_1_3_1_80_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.11.6643-6650.2001"},{"key":"e_1_3_1_81_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.1995.tb02180.x"},{"key":"e_1_3_1_82_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00587-07"},{"key":"e_1_3_1_83_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.1.592-598.2005"},{"key":"e_1_3_1_84_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-007-6142-8"},{"key":"e_1_3_1_85_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1301.060823"},{"key":"e_1_3_1_86_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402981101"},{"key":"e_1_3_1_87_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.2.1098"},{"key":"e_1_3_1_88_2","doi-asserted-by":"publisher","DOI":"10.1080\/08830180213274"},{"key":"e_1_3_1_89_2","first-page":"1","article-title":"Activation of the complement system by the capsule of Cryptococcus neoformans","volume":"5","author":"Kozel T. R","year":"1993","unstructured":"Kozel T. R . 1993. Activation of the complement system by the capsule of Cryptococcus neoformans. Curr. Top. Med. Mycol.5:1\u201326.","journal-title":"Curr. Top. Med. Mycol."},{"key":"e_1_3_1_90_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.31.3.978-984.1981"},{"key":"e_1_3_1_91_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.18.3.701-707.1977"},{"key":"e_1_3_1_92_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.43.2.574-579.1984"},{"key":"e_1_3_1_93_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.52.1.1-5.1986"},{"key":"e_1_3_1_94_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.56.11.2794-2800.1988"},{"key":"e_1_3_1_95_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.6.2336-2338.1996"},{"key":"e_1_3_1_96_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.59.9.3101-3110.1991"},{"key":"e_1_3_1_97_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.57.7.1922-1927.1989"},{"key":"e_1_3_1_98_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.60.8.3122-3127.1992"},{"key":"e_1_3_1_99_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.51.1.218-223.1986"},{"key":"e_1_3_1_100_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.3.952-958.2005"},{"key":"e_1_3_1_101_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.26.2.435-440.1979"},{"key":"e_1_3_1_102_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V76.11.2169.2169"},{"key":"e_1_3_1_103_2","doi-asserted-by":"crossref","first-page":"659","DOI":"10.4049\/jimmunol.142.2.659","article-title":"Paradoxical role of capsule in murine bronchoalveolar macrophage-mediated killing of Cryptococcus neoformans","volume":"142","author":"Levitz S. M.","year":"1989","unstructured":"Levitz S. M. DiBenedetto D. J. . 1989. Paradoxical role of capsule in murine bronchoalveolar macrophage-mediated killing of Cryptococcus neoformans. J. Immunol.142:659\u2013665.","journal-title":"J. Immunol."},{"key":"e_1_3_1_104_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.1.194-202.1994"},{"key":"e_1_3_1_105_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.58.5.1201-1209.1990"},{"key":"e_1_3_1_106_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119688"},{"key":"e_1_3_1_107_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.2.885-890.1999"},{"key":"e_1_3_1_108_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1567-1364.2006.00071.x"},{"key":"e_1_3_1_109_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115027"},{"key":"e_1_3_1_110_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.65.3.931-935.1997"},{"key":"e_1_3_1_111_2","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1997.4381"},{"key":"e_1_3_1_112_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.11.6034-6039.1999"},{"key":"e_1_3_1_113_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000252060.80704.68"},{"key":"e_1_3_1_114_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb\/9.6.617"},{"key":"e_1_3_1_115_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI18309"},{"key":"e_1_3_1_116_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03132.x"},{"key":"e_1_3_1_117_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/46.3.437"},{"key":"e_1_3_1_118_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2006.09.032"},{"key":"e_1_3_1_119_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-8-15"},{"key":"e_1_3_1_120_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.10.5787"},{"key":"e_1_3_1_121_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.5.3357"},{"key":"e_1_3_1_122_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1301.060827"},{"key":"e_1_3_1_123_2","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.4049\/jimmunol.120.5.1686","article-title":"Complement depletion in cryptococcal sepsis","volume":"120","author":"Macher A. M.","year":"1978","unstructured":"Macher A. M. Bennett J. E. Gadek J. E. Frank M. M. . 1978. Complement depletion in cryptococcal sepsis. J. Immunol.120:1686\u20131690.","journal-title":"J. Immunol."},{"key":"e_1_3_1_124_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.7.2851-2856.2005"},{"key":"e_1_3_1_125_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.11.6257-6264.2000"},{"key":"e_1_3_1_126_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.5.3053"},{"key":"e_1_3_1_127_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01232-08"},{"key":"e_1_3_1_128_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.25.1.262-267.1979"},{"key":"e_1_3_1_129_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200323626"},{"key":"e_1_3_1_130_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01119-08"},{"key":"e_1_3_1_131_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00176-07"},{"key":"e_1_3_1_132_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.59.1.24-28.1991"},{"key":"e_1_3_1_133_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2004.03921.x"},{"key":"e_1_3_1_134_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28842"},{"key":"e_1_3_1_135_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.5.4.491-498.1972"},{"key":"e_1_3_1_136_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.8.4.515"},{"key":"e_1_3_1_137_2","doi-asserted-by":"publisher","DOI":"10.1086\/315099"},{"key":"e_1_3_1_138_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200323388"},{"key":"e_1_3_1_139_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.181.1.405"},{"key":"e_1_3_1_140_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.60.11.4534-4541.1992"},{"key":"e_1_3_1_141_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.8.5367"},{"key":"e_1_3_1_142_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-3692(15)31671-8"},{"key":"e_1_3_1_143_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2006.00474.x"},{"key":"e_1_3_1_144_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.11.2490"},{"key":"e_1_3_1_145_2","doi-asserted-by":"publisher","DOI":"10.1086\/425121"},{"key":"e_1_3_1_146_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.6.2812-2819.2002"},{"key":"e_1_3_1_147_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.3.1538-1547.2003"},{"key":"e_1_3_1_148_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00454-09"},{"key":"e_1_3_1_149_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.080673"},{"key":"e_1_3_1_150_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00536-07"},{"key":"e_1_3_1_151_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328322ffac"},{"key":"e_1_3_1_152_2","doi-asserted-by":"publisher","DOI":"10.1086\/649858"},{"key":"e_1_3_1_153_2","first-page":"177","article-title":"Chronic cryptococcal meningitis: a new experimental model in rabbits","volume":"101","author":"Perfect J. R.","year":"1980","unstructured":"Perfect J. R. Lang S. D. Durack D. T. . 1980. Chronic cryptococcal meningitis: a new experimental model in rabbits. Am. J. Pathol.101:177\u2013194.","journal-title":"Am. J. Pathol."},{"key":"e_1_3_1_154_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.10.4360-4366.1993"},{"key":"e_1_3_1_155_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.2.820-827.2005"},{"key":"e_1_3_1_156_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/18.5.789"},{"key":"e_1_3_1_157_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00278-07"},{"key":"e_1_3_1_158_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.15.6.8969264"},{"key":"e_1_3_1_159_2","doi-asserted-by":"publisher","DOI":"10.1080\/00362178585380331"},{"key":"e_1_3_1_160_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.29.2.494-499.1980"},{"key":"e_1_3_1_161_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27890"},{"key":"e_1_3_1_162_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3020429"},{"key":"e_1_3_1_163_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.4.2229-2239.2004"},{"key":"e_1_3_1_164_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.5.1800-1807.1997"},{"key":"e_1_3_1_165_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.5.3244"},{"key":"e_1_3_1_166_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.5.2598-2604.2002"},{"key":"e_1_3_1_167_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00768-06"},{"key":"e_1_3_1_168_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.7.4620"},{"key":"e_1_3_1_169_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05397.x"},{"key":"e_1_3_1_170_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.3.1746"},{"key":"e_1_3_1_171_2","first-page":"861","article-title":"Activation of the plasma membrane H(+)-ATPase of Saccharomyces cerevisiae by addition of hydrogen peroxide","volume":"23","author":"Sigler K.","year":"1991","unstructured":"Sigler K. Hofer M. . 1991. Activation of the plasma membrane H(+)-ATPase of Saccharomyces cerevisiae by addition of hydrogen peroxide. Biochem. Int.23:861\u2013873.","journal-title":"Biochem. Int."},{"key":"e_1_3_1_172_2","doi-asserted-by":"publisher","DOI":"10.1086\/524738"},{"key":"e_1_3_1_173_2","first-page":"42","article-title":"Ecology of Cryptococcus neoformans","volume":"14","author":"Sorrell T. C.","year":"1997","unstructured":"Sorrell T. C. Ellis D. H. . 1997. Ecology of Cryptococcus neoformans. Rev. Iberoam Micol.14:42\u201343.","journal-title":"Rev. Iberoam Micol."},{"key":"e_1_3_1_174_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.9.2349-2355.2000"},{"key":"e_1_3_1_175_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199603213341206"},{"key":"e_1_3_1_176_2","doi-asserted-by":"publisher","DOI":"10.1080\/10715760100301171"},{"key":"e_1_3_1_177_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.182.1.84"},{"key":"e_1_3_1_178_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1320"},{"key":"e_1_3_1_179_2","doi-asserted-by":"crossref","first-page":"6148","DOI":"10.4049\/jimmunol.162.10.6148","article-title":"Regulation of the macrophage vacuolar ATPase and phagosome-lysosome fusion by Histoplasma capsulatum","volume":"162","author":"Strasser J. E.","year":"1999","unstructured":"Strasser J. E. Newman S. L. Ciraolo G. M. Morris R. E. Howell M. L. Dean G. E. . 1999. Regulation of the macrophage vacuolar ATPase and phagosome-lysosome fusion by Histoplasma capsulatum. J. Immunol.162:6148\u20136154.","journal-title":"J. Immunol."},{"key":"e_1_3_1_180_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8303277"},{"key":"e_1_3_1_181_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.11.5972-5981.2002"},{"key":"e_1_3_1_182_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1966.47"},{"key":"e_1_3_1_183_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.3.2100"},{"key":"e_1_3_1_184_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00328-X"},{"key":"e_1_3_1_185_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2007.11.004"},{"key":"e_1_3_1_186_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001310"},{"key":"e_1_3_1_187_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.60.9.3937-3939.1992"},{"key":"e_1_3_1_188_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.052702799"},{"key":"e_1_3_1_189_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.12.7629"},{"key":"e_1_3_1_190_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1002476"},{"key":"e_1_3_1_191_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00297-09"},{"key":"e_1_3_1_192_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1983"},{"key":"e_1_3_1_193_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.8.3131-3136.1995"},{"key":"e_1_3_1_194_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.7.3004-3007.1994"},{"key":"e_1_3_1_195_2","doi-asserted-by":"publisher","DOI":"10.1016\/0161-5890(91)90160-L"},{"key":"e_1_3_1_196_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.10.6456"},{"key":"e_1_3_1_197_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00274-06"},{"key":"e_1_3_1_198_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00317-06"},{"key":"e_1_3_1_199_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.7.2966-2972.1993"},{"key":"e_1_3_1_200_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.6.2483"},{"key":"e_1_3_1_201_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00094-07"},{"key":"e_1_3_1_202_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2008.01186.x"},{"key":"e_1_3_1_203_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2164(09)01204-0"},{"key":"e_1_3_1_204_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200323848"},{"key":"e_1_3_1_205_2","doi-asserted-by":"publisher","DOI":"10.1104\/pp.103.030023"},{"key":"e_1_3_1_206_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.11.7221"},{"key":"e_1_3_1_207_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-03-009720"}],"container-title":["Eukaryotic Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/EC.00039-10","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/EC.00039-10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T13:36:56Z","timestamp":1711373816000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/EC.00039-10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":206,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["10.1128\/EC.00039-10"],"URL":"https:\/\/doi.org\/10.1128\/ec.00039-10","relation":{},"ISSN":["1535-9778","1535-9786"],"issn-type":[{"value":"1535-9778","type":"print"},{"value":"1535-9786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6]]},"assertion":[{"value":"2010-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}